PubMed Health⌕ Search

Biomedical subjects

J S Cheigh

Publications and source records attributed to J S Cheigh.

78 records · Page 5Linked to original sources
PubMedDate not supplied

Infection following renal transplantation: a changing pattern.

The spectrum of infectious complications during the first six months after 101 consecutive renal transplants was examined. The most common sites of infection were the lungs, the urinary tract, and the surgical incision. The causative organisms were similar to those in nonimmunosuppressed postsurgical patients. The infections were usually recognized readily by routine clinical examination and responded promptly to antibacterial therapy. Three patients developed opportunistic infection. No patient died as a result of infection. As at several other institutions in recent years, a declining frequency of serious or opportunistic infection in these immunosuppressed patients was noted. However, the results of this study differed markedly from recently reported data which emphasize the importance of overt cytomegaloviral disease as a cause of morbidity and as a factor predisposing to serious--often fatal--superinfection. These differences may be related to the immunosuppressive agents used and certainly have important implications for diagnostic and therapeutic management.

Adolescent↗
PubMedDate not supplied

Induction of donor-specific immune modulation and successful renal transplantation with a simplified method of donor-specific blood transfusion.

We developed a new method of donor-specific blood transfusion (DST) for prospective kidney transplant recipients from a living related donor. Forty-four patients were transfused with 100 ml of one-haplotype matched kidney donor's whole blood at 1, 8, and 15 days after its storage. Ten of these patients received azathioprine (1.5 mg/kg per day) in addition to DST. After DST, three patients (6.8%) developed donor-specific lymphocytotoxic antibodies. The incidence of sensitization was not different between azathioprine-treated and untreated patients. Following DST, donor-specific mixed lymphocyte culture (MLC) was significantly suppressed without any accelerated (secondary type) response in early MLC. Subsequently, 24 patients received a kidney transplant from the donor. Graft survival rates were 96% and 90% at 12 and 24 months, respectively. Nine additional patients, seven from a two-haplotype matched sibling and two from a no-haplotype matched sibling also received DST. None of these patients became sensitized following DST, and all have functioning grafts for 6 to 18 months. This study indicates that 100 ml of stored whole blood DST three times at weekly intervals is a practical, less immunizing, and effective approach to enhance graft survival in recipients of a living related donor graft, DST produces donor-specific adaptive responses that might be conductive to successful graft outcome, and this protocol could be used in sibling donor-recipient pairs who do not share a haplotype.

Adult↗