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Biomedical subjects

J S Cho

Publications and source records attributed to J S Cho.

59 records · Page 4Linked to original sources
PubMedDate not supplied

Detection and characterization of hepatocellular carcinoma: value of dynamic CT during the arterial dominant phase with uniphasic contrast medium injection.

OBJECTIVE: Our goal was to assess the effect of dynamic CT during the arterial dominant phase with uniphasic injection of intravenous contrast material (5 ml/s) in the detection and characterization of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Three-phase incremental dynamic CT was performed in 66 patients with 84 HCCs diagnosed by pathologic findings, characteristic angiographic findings, and clinical manifestations. One hundred fifty milliliters of nonionic contrast medium was administered intravenously by using a power injector at a flow rate of 5 ml/s for 30 s, and three-phase images were obtained at 20-45 s (arterial dominant phase), 55-80 s (portal venous phase), and 2-4 min (equilibrium phase) after the start of uniphasic intravenous injection. Three-phase images in 66 patients were compared and assessed for the detectability and enhancement pattern of the tumors. RESULTS: The arterial dominant phase images of dynamic CT showed a moderate to marked hyperattenuation in 73 (87%) of the 84 HCCs, isoattenuation in 6 (7%), and hypoattenuation in 5 (6%). The portal venous phase images showed hyperattenuation in 6 (7%), isoattenuation in 45 (54%), and hypoattenuation in 33 (39%). In the equilibrium phase, CT findings showed hypoattenuation in 67 (80%) and isoattenuation in 17 (20%). The detectability of HCCs in the arterial dominant, portal venous, and equilibrium phase was 93, 46, and 80%, respectively. The detectability of HCCs in the arterial dominant phase was significantly (p < 0.0001) superior to that in both the portal venous phase and the equilibrium phase. CONCLUSION: Dynamic CT during the arterial dominant phase with uniphasic injection of intravenous contrast medium (5 ml/s) is a useful method in the detection and characterization of HCCs.

Adult↗
PubMedDate not supplied

Computed tomography in determining laryngeal involvement of hypopharyngeal carcinoma.

In 22 patients with hypopharyngeal carcinoma, the extent of laryngeal involvement was estimated preoperatively by means of computed tomography and visual inspection including mirror examination and fiberscopic and strobofiberscopic video recordings. All patients underwent laryngopharyngectomy, and the surgical specimens were subjected to a whole organ section study. The results of the preoperative evaluations were related to the histopathologic findings. Computed tomography was reliable for the estimation of paraglottic space involvements. It was also useful in detecting carcinomatous invasion into the preepiglottic space and aryepiglottic fold, but there were some false positives for these structures. It was not always reliable in assessing invasion of the laryngeal cartilages. It provided a very accurate estimation of involvement for the thyroarytenoid muscle and a considerably accurate assessment for the lateral cricoarytenoid and interarytenoid muscles and the recurrent laryngeal nerve. It was useful in detecting involvement of the posterior cricoarytenoid muscle, but there were a fair number of false positives. For the cricothyroid muscle, the estimation based on CT was not very reliable. Some erroneous judgments on CT were corrected in a comprehensive evaluation that included visual inspection.

False Negative Reactions↗
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The effect of leukotriene D4 on the patency of nasal passage in the guinea pig.

We investigated the effect of leukotriene D4(LTD4) on the patency of the nasal passage in nonsensitized and sensitized guinea pigs (GPs). The change in nasal patency was measured by acoustic rhinomanometry (AR). The change of volume from the nostril to 2 cm into the nasal cavity showed significant reduction at 30 minutes and 6 hours after instillation of LTD4 in nonsensitized GPs. These findings were also seen in nonsensitized and sensitized GPs with systemic administration of carboxyl cellulose. However, neither nonsensitized nor sensitized GP with systemic administration of benzopyren hemihydrate(ONO-1078) showed any changes in nasal patency. These results indicated that the LT was a potent medication to induce nasal obstruction of late reaction in GP.

Airway Resistance↗