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Biomedical subjects

J S Chow

Publications and source records attributed to J S Chow.

27 records · Page 2Linked to original sources
PubMed1983

Familial occurrence of mitral valve prolapse: is this related to the straight back syndrome?

Familial prevalence of mitral valve prolapse in a Chinese population was determined in 22 propositi of whom 10 had straight back (group A), three had abnormally high metacarpal index (group B), and nine had neither (group C). Of 71 (32 male and 39 female subjects) first degree relatives screened, mitral valve prolapse was found in 19 (seven male and 12 female subjects) (26.8%). The familial prevalence among groups A, B, and C was 20%, 30%, and 38.5%, respectively. Our study indicates that the familial occurrence of mitral valve prolapse does not depend on its association with the straight back syndrome.

Adolescent↗
PubMed1982

Is cardiac catheterisation necessary before valvular surgery?

The results of 269 patients who had undergone valvular operations during and 18-month period (January 1, 1980, to June 30, 1981) were analysed. One hundred and seventy-four patients referred for surgery had undergone routine cardiac catheterisation elsewhere, and these, together with four electively catheterised patients, constituted a group representing the conventional approach. Ninety-one patients were assessed only by clinical and non-invasive methods, including echocardiography, and were subjected to surgery without catheterisation. The two groups were comparable in their major clinical characteristics including age, sex ratio, functional class, previous history of closed mitral valvotomy, aetiology of valve lesions, and type of operative procedure performed. There was no discordance between operative finding and preoperative assessment, except in two patients of the catheterised group. Hospital mortality was acceptably low and was comparable between the two groups. Cardiac catheterisation is, thus, no longer necessary in the majority of patients undergoing surgery for valvular heart diseases.

Adult↗
PubMed1982

Mitral valve prolapse and pre-excitation.

Two out of 118 patients with mitral valve prolapse were found to have pre-excitation. The presence of mitral valve prolapse in one patient with Lown-Ganong-Levine syndrome and the persistence of prolapse in the presence and absence of pre-excitation in another patient with intermittent type B Wolff-Parkinson-White syndrome suggest that mitral valve prolapse in pre-excitation syndrome may not be secondary to the abnormal activation pattern of the left ventricle, which has been suggested as a possible mechanism by some investigators.

Adolescent↗
PubMed1976

Replication of dengue viruses in cultures of peripheral blood leukocytes from dengue-immune rhesus monkeys.

Dengue virus of types 1, 2, and 4 replicated reproducibly in cultures of peripheral blood leukocytes from 18 dengue-immune rhesus monkeys but failed to multiple in peripheral blood leukocytes from 25 nonimmune monkeys. Replication was observed at input multiplicity of infection of 0.1 and 0.01 but irregularly at less than or equal to 0.001. Dengue viruses in permissive leukocytes achieved maximal titers on days 2-4 of culture. Viral replication in peripheral blood leukocytes from animals immune to a different type of dengue virus and in animals immune to two or more types of dengue virus was quantitatively similar to that in peripheral blood leukocytes from homotypically immune donors. Dengue virus permissiveness developed between two and three weeks after primary dengue infections. Leukocytes of animals that developed immunity to dengue virus remained permissive to in vitro infection by dengue virus of types 1 and 2 for prolonged periods, but within six months permissiveness to type 4 decreased. Thus an immunological dependence of in vitro dengue virus replication in simian peripheral blood leukocytes was demonstrated.

Animals↗