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J S Dericks-Tan

Publications and source records attributed to J S Dericks-Tan.

At least 37 records · Page 2Linked to original sources
PubMed1988

[HCG in serum and peritoneal fluid in suspected ectopic pregnancy].

HCG was measured in peripheral serum and peritoneal fluid (PF), obtained by punction of the Douglas pouch (n = 12) or by laparoscopy (n = 14) in 26 patients with suspected ectopic pregnancy. In 10 patients with tubal pregnancy, the hCG-concentration in the PF was in every case higher than in serum. Contrary to this, in 11 disturbed and 2 normal intrauterine pregnancies the PF-hCG was lower than in serum. No hCG-gradient could be observed in 1 patient with an interstitial pregnancy. Moreover, in 2 patients with inconclusive laparoscopic findings, the PF-hCG was higher than in serum; this pointed to a probable harbouring of a suspected missed ectopic pregnancy, and treatment was therefore conservative. The PF-hCG level 35 h after i. m. application of 5000 IU hCG to non-pregnant women varied between 11 and 42% as compared to that of the serum. It is concluded that the gradient of hCG between PF and serum can be used for the verification of a suspected ectopic pregnancy in addition to other diagnostic methods.

Abortion, Spontaneous↗
PubMed1987

Spontaneous recovery of ectopic pregnancy: a preliminary report.

Twelve patients with silent (occult) ectopic pregnancy were clinically managed by a non-surgical conservative approach. The laparoscopic findings in 4 patients were not conclusive enough to justify laparotomy, and there was only minimal clinical symptomatology. The serum hCG level in these cases did not exceed 2000 IU/l and no typical rise was found. Serum hCG was measured serially under careful clinical observation until it reached non-pregnant levels over a period of 20-45 days. Tubal patency could be demonstrated 6 months later in 2 patients who desired to become pregnant.

Adult↗
PubMed1987

Double-stimulation with LH-RH in primary amenorrhea caused by chronic internal hydrocephylus: a case study.

A 19-year-old female patient with primary amenorrhea and pubertas tarda due to chronic internal hydrocephalus presented with normal hormonal findings except for low estradiol and a prepubertal type of reaction in the double-stimulation test with LH-RH. After successful operative treatment with a Spitz-Holter high-pressure valve, the intracranial decompression was promptly followed by pubertal development, she began to menstruate, and the LH-RH double-stimulation test showed an adult pattern of response. The results of the test support the view that a partial deficiency in the secretion of LH-RH is the cause of hypogonadism in such a case.

Adult↗
PubMed1986

Maternal serum alpha-fetoprotein levels in a triplet pregnancy with 2 papyraceous fetuses.

Serum Alpha-Fetoprotein (AFP) was found to rise to exceedingly high levels in a case of triplet pregnancy after two fetuses died in the 21st week of gestation. The surviving infant was born in the 36th week accompanied by the two fetus papyracei. By the time the process of mummification of the two dead fetuses appeared to be complete on ultrasound, the maternal AFP level had returned to the normal range for singleton pregnancies. HCG, hPL, and estriol and the coagulation profile remained within the normal range throughout the pregnancy.

Adult↗
PubMed1985

Inverse ratio of hCG in peritoneal fluid to that in serum in normal and tubal pregnancies.

The ratio of hCG in peritoneal fluid (PF) to that in serum (S) was studied in 60 patients with normal pregnancies (5th-15th wk of gestation = control group) and in 12 tubal pregnancies, 7 tubal abortions (5th-10th wk of amenorrhea) and one case of an early interstitial pregnancy (8th wk). The PF level in the control group was in every patient lower than in S independent of the gestational age. The ratio PF to S ranged from 0.24 to 0.87 (mean +/- S.E.: 0.51 +/- 0.02). In contrast to this, the patients with tubal pregnancy and tubal abortion showed in each case higher PF levels than in S. The ratio in the group with tubal pregnancy ranged from 1.1 to 374 (54 +/- 30) and in the group with tubal abortion from 1.2 to 162 (33 +/- 23). The difference in the ratio between the control group and both tubal pregnancy and tubal abortion was highly significant (P less than 0.001). The ratio of PF to S in the patient with interstitial pregnancy (0.73) did not differ from the control group. At the time of investigation, the S levels in all but 2 patients with ectopic pregnancy were below the range for normal pregnancy of the same gestational age. These findings indicate that the hCG ratio of PF to S may be dependent on the location of the gestational product.

Abortion, Spontaneous↗
PubMed1985

[AFP and HbF determination in maternal blood as a parameter of fetomaternal microtransfusion in interventions of the pregnant uterus].

The applicability of AFP assay (radioimmunologic) and of erythrocytes containing Hb-F (Kleihauer et al. 1957) in maternal blood as a means of detecting fetomaternal microtransfusion was examined in 57 cases of abruptio and 65 women in whom genetically indicated amniocentesis was performed. There was a significant increase in AFP postoperatively in 40% of the abruptiones; after amniocenteses such behavior was far less pronounced (18.5%). The count of cells containing Hb-F in maternal blood smears revealed no significant increase in any of the cases examined. A correlation on the basis of these examination results is therefore unlikely. However, an evaluation of them demands that the assay methods used for AFP and Hb-F cells and, above all, their physiology, be taken into account. The diaplacental passage rates of the two substances are probably different, and under certain conditions they may also be produced by the maternal organism to a varying extent. It could be concluded from this that even though the AFP assay involves a simpler method and is more sensitive, neither parameter can replace the other, and therefore neither can be made the basis for a decision against anti-D immunoglobulin prophylaxis.

Abortion, Induced↗
PubMed1984

Pseudohypergonadotropinemia and pseudohyperprolactinemia induced by heterophilic antibodies?

The serum of 20 apparently hypergonadotropic and/or hyperprolactinemic patients (14 females, 6 males, ages 13-75 years) without evidence of neoplasia or pituitary adenomas was found to contain a large amount of molecular material (MW ca. 100,000) resulting in factitiously elevated levels of peptide hormones when measured by double-antibody radioimmunoassay with a long second incubation time. The interference by this material with the test system could be avoided by using polyethylene glycol (PEG) for the separation of free from bound antigen, or by preincubation of the samples with normal rabbit serum. No definite disease process can as yet be linked to these findings. They rather seem to be caused by the presence of heterophilic antibodies in serum, as the serum of approximately one half of the patients was found to give a positive Paul-Bunnell test. Moreover, the beta hCG activity in the urine of these patients was low, probably as a result of the low clearance of substances with igh MW. It is therefore suggested to apply to following diagnostic measures before clinical consequences are being considered in a case of hypergonadotropinemia and/or hyperprolactinemia without pertinent clinical findings: (1) validation of the immunoassay, (2) preincubation of the samples with serum from other species, (3) the use of another separation procedure than the double-antibody method, and (4) measurement of the respective hormone in urine.

Adolescent↗
PubMed1983

Synthesis and release of gonadotropins: effect of an oral contraceptive.

A double-stimulation test with 100 micrograms gonadotropin-releasing hormone per dose given twice within two hours was carried out in eight normally cyclic women before and during treatment with a combined oral contraceptive (30 micrograms ethinyl-estradiol + 150 micrograms desogestrel). The test was performed on days 8 to 11, 19 to 22, and 24 to 27 of a control cycle, and during the first and third treatment cycles. This oral contraceptive was found to diminish the capacity of the gonadotropes for the synthesis of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to a higher degree than that for the acute release in each treatment cycle. During the treatment-free interval, the reaction of LH differed from that of FSH: while the release of the former remained suppressed, that of FSH did not differ from the control cycle.

Adolescent↗
PubMed1982

[The significance of alpha-feto-protein (AFP) and human chorionic gonadotrophin (HCG) during the first half of pregnancy (author's transl)].

The determination of AFP and HCG was used as a diagnostic parameter for the functional integrity of the feto-placental unit during the first 20 weeks of normal and disturbed pregnancies. In contrast to HCG which can already be detected very shortly after nidation and reaches a maximum between the 10th and 12th week of gestation, AFP does not begin to rise discernibly before the 8th and 9th week and attains the highest values in the third trimester. The assay of AFP did not contribute relevant data when carried out before the 10th week of pregnancy. Contrary to that, an irreversibly damaged pregnancy has to be expected when lower than normal AFP values are found after the 10th week, even in the presence of a normal level of HCG. Likewise, higher than normal values should be taken as a reliable sign of embryonal demise after the 14th week of pregnancy, as long as a multiple gestation, a previous amniocentesis or a neural tube defect can be excluded. Serum AFP did not only increase markedly in many cases after interruption of pregnancy, but even after amniocentesis or premature rupture of the amniotic sac when fetal cells having a high content of AFP enter the maternal circulation.

Abortion, Spontaneous↗
PubMed1980

The mechanism of action of a new low-dosed combined oral contraceptive.

The effect of a new low-dosed combined oral contraceptive (OC) containing 37.5 microgram ethinyl estradiol and 0.75 mg lynestrenol (Ovoresta M) upon gonadotropin release and follicular activity was studied in two groups of normally cyclic women. When the administration of the OC was started on day 1 of the cycle, the normal pattern of gonadotropin secretion was disrupted, and the midcycle LH and FSH peak was abolished. The mean level of LH and FSH was somewhat lower than in normal cycles, but the difference was not significant. In one case, serum estradiol rose to the level of the normal cycle indicating follicular activity. Even though there was a rise in serum estradiol to normal values when the OC was started on day 10 of the cycle (in 4/5), both the midcycle LH and FSH surge and ovulation were suppressed (in 3/4). The pituitary response to 100 microgram LH-RH on day 21 was impaired. The LH-response correlated significantly with the serum estradiol concentration. In summary, the low-dosed OC exerts its effect by interfering with follicular ripening and inhibiting the preovulatory LH surge.

Adult↗
PubMed1980

[Early diagnosis of molar pregnancy by measuring AFP and HCG in serum (author's transl)].

In 3 women with the histologically confirmed diagnosis of molar pregnancy (in one case dizygote), the time-course of the concentration of HCG and AFP was measured in serum prior to expulsion and curettage, respectively. Serum HCG was found to be in the normal range of monozygotic and dizygotic pregnancies. Contrary to that, serum AFP was lower than normally seen and showed a tendency to decline even further. This seems to indicate that AFP is a valuable diagnostic adjunct to the determination of serum HCG in the diagnosis of disturbances of early pregnancy characterized by embryonic demise (molar pregnancy, blighted ovum), as it is a parameter of fetal integrity rather than that of normal trophoblastic function.

Chorionic Gonadotropin↗
PubMed1979

[Rapid radioimmunological test for HCG in normal and disturbed early pregnancy (author's transl)].

The clinical evaluation of a rapid radioimmunological test for HCG in serum showed that this method is as suitable as conventional radioimmunoassay or receptor methods in the diagnosis of normal and disturbed early pregnancy. Using a direct immunosorbent method total time requirements for the estimation could be reduced to half a working day. Sera of 314 women with normal pregnancies showed an exponential increase of HCG concentrations in serum during the first 8 weeks and thereafter steady levels for several weeks. As the anti-HCG serum used has only a slight cross reactivity with LH, false-positive results need hardly be expected in states of high LH levels in serum (menopause, polycystic ovaries, preovulatory LH peak). HCG concentrations in serum were clearly diminished in all pregnancies ending in abortion and in nearly all extrauterine pregnancies. Repeated estimations in early pregnancy enable a diagnosis of ectopic or disturbed intrauterine pregnancy to be made before symptoms of rupture, haemorrhage and similar complications occur.

Abortion, Spontaneous↗
PubMed1979

The biological activity of dimeric testosterone, a new long-acting androgen, and of testosterone enanthate in the castrated male rat.

The long-term effect of single intramuscular injections of various doses of dimeric testosterone and of testosterone enanthate into castrated male rats upon serum testosterone, luteinizing hormone (LH), pituitary LH, and on the weight of the seminal vesicles, the ventral prostate and the levator ani muscle, was investigated. The effect of the enanthate was characterized by a rapid onset and a protracted androgenic action and a suppression of serum LH, while the dimeric testosterone brought about only a moderate but very even depot effect. The injection of 5 mg of the dimeric testosterone caused a positive feedback effectu upon LH release for 16 weeks. The results indicate that the dimeric testosterone may exert is hormonal effects as intact ester.

Animals↗