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Biomedical subjects

J S Elder

Publications and source records attributed to J S Elder.

At least 19 recordsLinked to original sources
PubMed1992

The accuracy of antenatal ultrasonography in identifying renal abnormalities.

OBJECTIVE: To determine the accuracy of measuring antenatal renal pelvic diameter for prediction of renal abnormalities. RESEARCH DESIGN: Prospective evaluation of all pregnant women undergoing ultrasonography. SETTING: A teaching hospital providing primary and referral maternity care. PARTICIPANTS: Fifty-six pregnant women with suspected fetal hydronephrosis or cystic lesions identified from 7500 ultrasonograms over 3 years. METHODS: Antenatal renal pelvic diameter was measured in the anteroposterior dimension. Neonates underwent postnatal ultrasonography after day 3 of life; if the results were abnormal, a cystogram and renal diuretic scan were obtained. RESULTS: None of 50 kidneys 15 mm or smaller in anteroposterior pelvic diameter had obstruction; 11 (79%) of 14 kidneys larger than 15 mm were obstructed or demonstrated vesicoureteral reflux. Of 12 kidneys believed to be multicystic before birth, five (42%) proved to have hydronephrosis. CONCLUSIONS: Since the majority of fetuses with suspected hydronephrosis proved to be normal, parents should not be unduly alarmed by the physician. Renal pelvic diameter of more than 15 mm is strongly predictive of hydronephrosis. Since severe hydronephrosis is treatable and can be mistaken for a multicystic kidney antenatally, full radiologic evaluation is needed soon after birth.

Congenital Abnormalities↗
PubMed1992

Continent appendicocolostomy: a variation of the Mitrofanoff principle in pediatric urinary tract reconstruction.

There are numerous options for continent urinary reconstruction in children. If the appendix is available and the bladder capacity is satisfactory, a Mitrofanoff procedure may be performed using the appendix as a catheterizable tube implanted into the bladder. However, in many patients the bladder is absent or too small for this type of reconstruction. An alternative technique, termed appendicocolostomy, is to implant the appendix under the tenia of a detubularized patch of cecum or sigmoid colon, which becomes part of a continent neobladder or is attached to the bladder itself. This procedure has been used in 12 children and 1 adult undergoing continent reconstruction. Urological diseases included bladder exstrophy (10 patients) and a neuropathic bladder (3). Two patients underwent undiversion of a sigmoid conduit, while in 7 of the remaining patients the bladder was included in the reservoir. In 1 patient histological examination of the tip of the appendix revealed an incidental invasive carcinoid tumor necessitating appendectomy and revision of the reconstruction. Otherwise, no complications have occurred. Three adults were scheduled for this procedure but the appendix was diseased and an alternative form of diversion was necessary. Followup ranged from 2 months to 4 years. All patients are totally dry with a capacity of 300 to 750 cc (mean 475 cc). The appendicocolostomy is a superior form of conduit reconstruction that should be considered when the appendix is available during continent reconstruction. However, in adults the appendix may be fibrotic, precluding its use. Because most boys with exstrophy and a small bladder capacity requiring augmentation cystoplasty must perform intermittent catheterization, attachment of the appendix to the reservoir is an alternative that allows for easier and less painful intermittent catheterization than catheterization of the reconstructed epispadiac penis.

Adolescent↗
PubMed1992

Epididymal anomalies associated with hydrocele/hernia and cryptorchidism: implications regarding testicular descent.

Controversy exists regarding the role of the epididymis in testicular descent, as epididymal abnormalities have been reported in 36 to 79% of boys with an undescended testis. Although most undescended testes are associated with a patent processus vaginalis, the incidence of epididymal abnormalities in descended testes with a patent processus has not been reported. Epididymal morphology was examined in 81 boys with a hydrocele/hernia without cryptorchidism (90 testes) and 100 children undergoing orchiopexy (115 testes). Boys with an intra-abdominal undescended testis were excluded. Among 48 boys with a hydrocele/hernia 24 (50%) had an epididymal abnormality if the processus was patent and communicated with the testis (complete hernia), compared to 4 of 42 patients (10%) if there was not a communication with the testis (p less than 0.01). Among the 96 children with an undescended testis 68 (71%) had an epididymal abnormality if there was a patent processus, compared to 3 of 19 boys (16%) without a patent processus (p less than 0.01). These data suggest that most epididymal abnormalities probably do not contribute to testicular maldescent.

Adolescent↗
PubMed1992

Variations in practice among urologists and nephrologists treating children with vesicoureteral reflux.

To analyze the current management recommendations among physicians treating children with vesicoureteral reflux, the American Urological Association Reflux Practice Guidelines Panel surveyed 100 pediatric urologists, 100 general urologists and 100 pediatric nephrologists by questionnaire, and received a 60% response. In the evaluation of a 4-year-old girl with bilateral grade 2 reflux general urologists were more likely than the other 2 groups to recommend cystoscopy and urethral dilation. At followup nuclear cystography was recommended by 76% of pediatric urologists, 48% of general urologists and 71% of pediatric nephrologists, while the latter 2 groups were less likely to recommend any subsequent upper tract evaluation. Pediatric urologists were significantly more likely to recommend antireflux surgery if the child had 1 breakthrough febrile urinary tract infection, poor compliance with medical management or persistent reflux at age 11 years. In a 6-year-old girl with unilateral grade 4 reflux and detrusor instability 44% of pediatric urologists recommended antimicrobial prophylaxis and anticholinergic therapy compared to 12% of general urologists and 6% of pediatric nephrologists. Antireflux surgery was recommended by 29% of pediatric urologists, 60% of general urologists and 59% of pediatric nephrologists. In older girls with persistent grade 2 or 3 reflux pediatric urologists were much more likely to recommend antireflux surgery. In contrast, they were less likely to recommend surgery in young girls and boys with newly diagnosed grade 4 reflux. These data demonstrate significant differences in therapeutic recommendations among pediatric urologists, general urologists and pediatric nephrologists, and suggest the need for outcomes research to determine the optimal management of children with vesicoureteral reflux.

Child↗
PubMed1992

Two-stage Fowler-Stephens orchiopexy in the management of intra-abdominal testes.

Of 22 boys with an intra-abdominal testis 8 (12 testes) underwent the 2-stage Fowler-Stephens orchiopexy. During stage 1 the testicular artery and internal spermatic vein were ligated in situ 2 to 3 cm. superior to the intra-abdominal testis. The testicular vessels were transected inferior to the ligatures 6 months later and the testis was brought to the scrotum with the standard Fowler-Stephens orchiopexy technique. Patient age ranged from 1 to 6 years (mean 3.2 years). At followup 11 of 12 testes (92%) are in the scrotum and have a normal consistency and size, while 1 (8%) is atrophic. In this preliminary series the 2-stage Fowler-Stephens orchiopexy has a success rate equal or possibly superior to the standard Fowler-Stephens orchiopexy. Whether ultimate testicular function is improved, however, remains to be determined.

Child↗
PubMed1992

Commentary: importance of antenatal diagnosis of vesicoureteral reflux.

Although hydronephrosis detected by prenatal ultrasonography often is assumed to be secondary to obstructive uropathy, in approximately 10% of the cases renal pelvic dilatation results from primary vesicoureteral reflux. More than 80% of neonates with reflux are male and two-thirds have bilateral reflux. Approximately 80% have at least grade III reflux. At birth between a third and half may have reduced renal function on isotope renography, even in the absence of urinary infection. Approximately 20% of neonates with grade IV or V reflux followed nonoperatively experience spontaneous reflux resolution by age 2 years. However, in approximately 25% of boys followed nonoperatively urinary tract infections developed by age 2 years despite antimicrobial prophylaxis. Because the majority of these boys have been uncircumcised, circumcision seems advisable. Ureteral reimplantation should be reserved for those with breakthrough urinary tract infection, new renal scars or persistent high grade reflux.

Child, Preschool↗
PubMed1991

Genitourinary tract malformations and maternal cocaine abuse.

We report on 4 cases of congenital urologic anomalies in association with maternal cocaine abuse and review all 23 cases documented in the literature. Male infants predominate and have either isolated genital abnormalities, hydronephrotic conditions, or classic prune-belly syndrome. Female infants present with hydronephrosis or cloacal abnormalities along with masculinization of the external genitalia. Cocaine disrupts morphogenesis by causing intense vasoconstriction of the uterine and fetal circulation. Interruption of calcium metabolism may also be responsible for the hydronephrosis observed.

Abnormalities, Drug-Induced↗
PubMed1990

Periurethral and puboprostatic sling repair for incontinence in patients with myelodysplasia.

The surgical management of sphincteric incompetence in patients with myelodysplasia is a formidable problem. In 10 female patients and 4 male patients with myelodysplasia a free graft of rectus fascia was used to suspend the urethra, termed the periurethral and puboprostatic sling procedures, respectively. All but 1 patient also underwent augmentation cystoplasty, usually with sigmoid colon. Patient age ranged from 7 to 25 years (mean 12.6 years) and followup ranged from 2 to 27 months (mean 12 months). Of the patients 12 are completely dry on clean intermittent catheterization, 1 has undergone 2 subsequent urethral suspension procedures but remains incontinent and 1 experiences nocturnal enuresis but is dry during the day. The periurethral sling appears to be as effective as the artificial urinary sphincter, the Young-Dees-Leadbetter bladder neck reconstruction and the Kropp procedure in the management of sphincteric incompetence in female patients. In male patients experience with the puboprostatic sling is limited but thus far it is encouraging.

Adolescent↗
PubMed1990

Evaluation of fetal renal function: unreliability of fetal urinary electrolytes.

In the fetus with bilateral hydronephrosis it has been reported that a normal volume of amniotic fluid, absence of renal cortical cysts, urinary sodium less than 100 mEq./l., chloride less than 90 mEq./l. and osmolarity less than 210 mOsm. are prognostic factors indicative of good renal function, whereas oligohydramnios, cortical cysts and higher urinary levels of sodium, chloride or osmolarity suggest irreversible renal dysplasia. We report 5 cases in which the fetal urinary electrolytes were not predictive of ultimate renal function. In 3 instances fetal urinary electrolytes and osmolarity were abnormally elevated but the infants survived without ventilatory support. In 2 of these 3 patients the volume of amniotic fluid was normal. Diagnoses included posterior urethral valves, prune belly variant and bilateral ureteropelvic junction obstruction. In 2 cases with oligohydramnios fetal urinary electrolytes were suggestive of satisfactory renal function but the infants died of pulmonary hypoplasia and had bilateral renal dysplasia, prune belly syndrome and urethral atresia. Presently, the volume of amniotic fluid remains the most important prognostic sign in the fetus with bilateral hydronephrosis. Further work is necessary to identify other factors that may be more reliable as prognostic indexes of fetal renal function.

Electrolytes↗
PubMed1989

Infant testicular prostheses.

Traditionally, the parents of young boys with an absent testis are advised to let the child decide whether he wants a testicular prosthesis after he enters puberty. Unfortunately, the decision by an adolescent to undergo prosthesis insertion often is made only after experiencing ridicule and embarrassment about the genital appearance. Accordingly, we have offered to implant an infant size prosthesis in patients with cryptorchidism when inguinal and abdominal exploration demonstrates that the testis is absent. A total of 41 boys less than 5 years old with an absent testis underwent simultaneous insertion of a testicular prosthesis. The only complication was a superficial wound infection that did not necessitate removal of the prosthesis. Two boys report mild scrotal discomfort. In long-term followup 91 per cent of the families rated the cosmetic appearance as "good" and 94 per cent were content with the decision regarding placement of a prosthesis. Although many assume that these boys will desire a larger prosthesis after puberty, this consideration seems to be irrelevant. Longer followup will be necessary to ascertain whether this approach alters the psychosexual development of these patients. We believe that young boys with an absent testis should be considered for simultaneous testicular prosthesis insertion at inguinal exploration or orchiectomy.

Body Image↗
PubMed1989

Laparoscopy and Fowler-Stephens orchiopexy in the management of the impalpable testis.

In children with an impalpable testis, laparoscopy is a valuable procedure that can be used in conjunction with inguinal and abdominal exploration to localize the testis. The instrumentation and technique of laparoscopy are described. If the testis is intra-abdominal, a Fowler-Stephens orchiopexy often is successful. Staging the Fowler-Stephens orchiopexy, with preliminary ligation of the testicular vessels in situ, followed 6 months later with transection of the vessels and orchiopexy, may improve the success of this technique by allowing collateral arterial flow to develop with minimal risk of arterial spasm.

Child↗
PubMed1988

Infected urachal cysts: a review of 10 cases.

Disorders of urachal remnants are uncommon. While a urachal cyst usually is asymptomatic, infection may mimic a variety of acute intra-abdominal or pelvic processes. We describe 10 patients in 2 distinct age groups (the young child and the young adult) with an infected urachal cyst. The presenting symptoms and signs in most patients included dysuria, severe lower abdominal pain and fever. In 7 patients the correct preoperative diagnosis was made. Diagnoses at referral included Crohn's disease, bladder carcinoma and pelvic inflammatory disease. A single procedure was performed in 7 cases and a staged technique was used in 3. The differential diagnosis of acute abdominal and pelvic pain or a midline lower abdominal mass in the pediatric or young adult age group should include infection of a urachal remnant.

Adult↗
PubMed1988

Perforation of the augmented bladder in patients undergoing clean intermittent catheterization.

During urological reconstructive surgery small or large bowel is used to increase bladder capacity or to create a urinary reservoir. In most patients clean intermittent catheterization is necessary for urinary drainage. We report on 4 patients with a sigmoid cystoplasty who perform clean intermittent catheterization and who have experienced a serious long-term complication, urinary reservoir perforation, which was fatal in 1. Two were adolescent girls with myelodysplasia and 2 were prepubertal boys with bladder exstrophy. One patient experienced 2 separate reservoir perforations. Rupture occurred 15 to 48 months (mean 30.2 months) after reconstruction. Diagnosis was made by a static cystogram, which demonstrated extravasation in 2 of 4 patients, and ultrasound. In 2 patients the cystogram was normal. Management included intravenous antibiotics and open abscess drainage in all patients. In patients who have undergone augmentation cystoplasty or continent diversion and in whom abdominal pain and distension develop reservoir perforation should be considered in the differential diagnosis.

Adolescent↗
PubMed1988

The undescended testis. Hormonal and surgical management.

Cryptorchidism is the most common disorder of sexual differentiation in males, with an incidence of 3.4 per cent in the term newborn, decreasing to 0.8 per cent at 1 year of age. The mechanisms of normal testicular descent are multifactorial and include an intact hypothalamic-pituitary-testicular axis, as well as a normal gubernaculum and epididymis. In boys with cryptorchidism, the testes demonstrate degenerative changes histologically as early as 1 to 2 years of age. Both testes may be affected, even with a unilateral undescended testis. The most important long-term complications of cryptorchidism include infertility and testicular cancer. The risk of malignancy is 10 to 40 times higher in men with cryptorchidism than in normal men and is highest in men who have had an intra-abdominal testis and in certain intersex conditions. Orchiopexy does not appear to lessen this risk. In clinical trials in the United States, hormonal therapy with hCG or GnRH has not been effective in causing testicular descent; therefore, orchiopexy remains standard treatment. However, hCG is recommended if the clinician suspects that a testis is retractile. Orchiopexy should be performed between 12 and 18 months of age to prevent the degenerative changes that are demonstrable by 2 years.

Chorionic Gonadotropin↗
PubMed1988

Teaching catheterization to children.

Children can learn to perform self-catheterization as early as their preschool years with the aid of newly developed teaching techniques. Clean self-catheterization is widely accepted and allows the child to remain dry, without infection, and independent in the management of the lower urinary tract.

Age Factors↗
PubMed1987

Intervention for fetal obstructive uropathy: has it been effective?

The best management of fetal hydronephrosis is controversial. Despite the lack of experimental evidence that prenatal drainage of the obstructed urinary tract substantially improves ultimate renal function, various forms of percutaneous intervention on the fetal bladder and kidney have been used. To evaluate the efficacy of intervention for suspected fetal obstructive uropathy, all published reports of drainage of the fetal urinary tract up to December, 1985, were reviewed. In the 57 reported cases, the most common type of intervention was placement of a vesicoamniotic shunt (37%). Complications occurred in 25 cases (44%), including inadequate shunt drainage or migration (19%), onset of premature labour within 48 h (12%), urinary ascites (7%), and chorioamnionitis (5%). Of 28 fetuses with associated oligohydramnios, only 6 (21%) survived. 2 of these survivors had vesicoamniotic shunts, 2 single or multiple bladder aspirations, 1 an external renal drainage catheter, and 1 in-utero vesicostomy. Because of the high complication rate and lack of evidence of improved survival from in-utero drainage procedures, a prospective, randomised trial is needed to compare survival with and without vesicoamniotic shunt placement.

Amnion↗