PubMed Health⌕ Search

Biomedical subjects

J S Fleishman

Publications and source records attributed to J S Fleishman.

6 recordsLinked to original sources
PubMed1985

Pulmonary lymphangioleiomyomatosis: quantitative analysis of lesions producing airflow limitation.

The lungs of three patients dying of lymphangioleiomyomatosis (LAM), which in two of the patients was associated with tuberous sclerosis, were studied to characterize better the sites of airflow limitation in this condition. Quantitative studies showed that small airways were narrowed and collapsed because of the surrounding emphysema, but few airways contained excess smooth muscle. These findings suggest that the airspace lesions are more important than muscular proliferation in small airways in producing airflow limitation. In the two patients who had LAM with tuberous sclerosis, sex steroid assays were negative. Pleurodesis controlled pleural effusions in all three patients but may have contributed to reductions in lung volume.

Adult↗
PubMed1983

Hibernoma: ultrastructural observations.

A light and electron microscopic study of a hibernoma and a brief discussion of the functional role of brown fat are presented. The multivacuolar cells composing brown fat have central round nuclei with prominent nucleoli. The quantity of mitochondria and lipid droplets in the cytoplasm of the cells varies considerably. The electron microscopic findings of hibernoma include multivacuolated and univacuolated cells with varying numbers of lipid vacuoles, lysosomes, lipofuscin granules, pinocytotic vesicles, and possibly prominent subplasmalemmal condensations. Interesting findings in this case include the presence of amorphous diastase resistant perodic acid (PAS) Schiff positive peripheral cytoplasmic masses which are variable in size and shape. These collections also appear extracellularly. The presence of these masses, presumably composed of neutral mucopolysaccharides, has not, to our knowledge, been recorded previously.

Adipose Tissue, Brown↗
PubMed1981

Association of insulinoma with subcutaneous nodular fat necrosis.

A 57-year-old man first noted tender subcutaneous nodules on his extremities and abdomen. Six months later symptoms of insulin hypersecretion became evident and hyperinsulinemia was documented. An exploratory laparotomy revealed an islet cell tumor measuring 12 cm in diameter extending anteriorly from head of the pancreas with metastases in the liver. Evidence of parathyroid and pituitary hormone hypersecretion suggests that the insulinoma may be part of a multiple endocrine neoplasia syndrome. Histological examination of the subcutaneous nodules revealed the characteristic histology of nodular fat necrosis. This is the first report of the association of an insulin-secreting islet cell carcinoma with subcutaneous nodular fat necrosis.

Adenoma, Islet Cell↗