Staphylococcal toxic shock syndrome.
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Adolescent↗
Biomedical subjects
J S Gibson
Publications and source records attributed to J S Gibson.
The use of anesthetic drugs to reduce ICP changes in head-injured patients.
Chest physiotherapy causes increases in intracranial pressure (ICP) in patients with severe head injuries. In mechanically hyperventilated severe head injuries (PaCO2 3.3 - 4 kPa) 50% nitrous oxide in 50% oxygen exacerbated ICP increases associated with chest physiotherapy, while thiopentone and Althesin reduced these changes in ICP.
Alfaxalone Alfadolone Mixture↗
The effects of theophylline on mucosubstance secretion by rous sarcoma cells.
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Animals↗
Oxygen-sensitive cation transport in sickle cells.
There are many examples of O2-sensitive solute transport in vertebrate red cells. The response is selective, specific, and conserved across the entire vertebrate spectrum. A number of possible physiological roles have been proposed, but abnormal responses to O2 may also be important pathologically. Significant alterations in O2 dependence of red cell cation transport are observed in sickle cell disease (and also following exposure to oxidants) and probably contribute to its pathophysiology. In this paper, we review some of the features of O2-sensitive solute transporters in red cells and possible reasons for the abnormal response in sickle cells. Our aim is to identify specific, novel pharmacological inhibitors of these abnormal pathways and thereby ameliorate the disease.
Anemia, Sickle Cell↗
Membrane transport in sickle cell disease.
We have reviewed here a number of membrane transport events in red cells from normal individuals and sickle cell patients which respond to changes in O(2) tension. Some deoxygenation-induced changes in membrane permeability are unique to HbS cells and contribute to their dehydration and subsequent sickling. Polymerization of HbS, or specific oxidant damage (or altered redox potential), is a likely factor underlying the abnormal behavior. The key regulatory sites within the membrane or associated proteins remain uncertain and their identity will form the focus of future research. A model for sickle cell dehydration is presented. Inhibition of these permeability changes represents possible avenues for future chemotherapy to ameliorate the condition.
Anemia, Sickle Cell↗