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J S Graham

Publications and source records attributed to J S Graham.

41 records · Page 3Linked to original sources

Locus of control and cardiac response to reaction time, mental arithmetic, and time-estimation tasks.

In Exp. 1 subjects, classified on the basis of locus of control scores, performed both reaction time and mental arithmetic tasks. In Exp. 2, similarly classified subjects were required to estimate the duration of a signal with feedback following each trial. Between-groups comparisons in Exp. 1 showed no differences on heart rate or performance measures. This does not support an explanation of differential heart rates during cardiac conditioning based upon cognitive styles of "rejecting" or "accepting" stimuli. Similar comparisons in Exp. 2 indicated significant differences for heart rate and proficiency in time estimation. These differences suggest greater task involvement for internally controlled subjects on feedback tasks, with cardiac acceleration a function of that involvement.

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Microtubule-associated protein 2 (MAP-2): a sensitive marker of seizure-related brain damage.

We have assessed the efficacy of MAP-2 immunohistochemistry as a marker of seizure-related brain damage and its suitability for quantitation of the damage using densitometric and morphometric image analysis. Seizures were produced in rats by administration of 1.5 LD50 soman, an irreversible AChE inhibitor. Our results demonstrate that neuronal damage, assessed using hematoxylin and eosin, and cresyl violet staining, was colocalized on adjacent serial sections with clearly demarcated reductions in MAP-2 staining. The most severely damaged brain regions were devoid of MAP-2 staining. Reductions in MAP-2 immunostaining were found to be exceptionally well suited for quantitation using densitometric and morphometric image analysis. This study represents the first demonstration of seizure-induced excitotoxic alterations in MAP-2.

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