Biomedical subjects
Publications and source records attributed to J S Hanson.
We present here an unusual case of a pancreatic gastrinoma that caused recurrent episodes of clinical pancreatitis secondary to complete obstruction of the main pancreatic duct. The patient did not manifest signs or symptoms of peptic ulcer disease.
Exercise capacity increases to a variable degree in coronary patients during cardiac rehabilitation. The effect of baseline exercise-induced ischemia on the response to a 12-week conditioning program was evaluated in 106 coronary patients. The magnitude of exercise conditioning response was greater in nonischemic patients than in ischemic patients, with maximal exercise intensity increasing 69 versus 50% (7.2 to 12.1 vs 7.1 to 10.6 METs) (p less than 0.05) and maximal oxygen consumption increasing 28 versus 10% (23.1 to 29.6 vs 23.0 to 25.4 cc/kg/min) (p less than 0.05). Markers of conditioning during submaximal exercise such as heart rate and heart rate-systolic blood pressure product were similarly reduced in both groups. The groups did not differ by age, diagnosis, resting ejection fraction, incidence of beta-blocker use, maximal exercise capacity, maximal exercise heart rate, blood pressure or intensity of actual exercise training. These results suggest that exercise-induced ischemia alters the stimulus to adapt to exercise training.
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To determine the effect of beta-adrenergic blockade on the submaximal stress test after acute myocardial infarction (AMI), 36 post-AMI patients performed their treadmill test on 2 separate days, with and without metoprolol, in a double-blind, placebo-controlled, crossover design study. Rest and peak submaximal exercise heart rate was diminished by 100 mg of metoprolol administered twice daily (from 84 +/- 3 to 68 +/- 2 beats/min, p less than 0.001, and from 126 +/- 3 to 97 +/- 2 beats/min, p less than 0.001, respectively) compared with placebo. Rest and peak submaximal systolic blood pressure was also decreased (from 121 +/- 3 to 108 +/- 2 mm Hg, p less than 0.001, and from 151 +/- 4 to 124 +/- 3 mm Hg, p less than 0.001). Exercise-induced ST-segment depression of 1 mm or more from baseline occurred in 12 patients taking placebo. However, only 4 of these patients had ST depression when they exercised while taking metoprolol (p less than 0.05). Angina pectoris occurred in 4 patients taking placebo but in only 1 of these taking a beta-blocking drug. It is concluded that beta-blocking therapy renders the post-AMI submaximal stress test less sensitive for markers of exercise-induced ischemia than if the test is performed without the drug. Therefore, when using the prognostic information of published studies, it is important to define the conditions surrounding the exercise test.
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The capabilities of a mini-computer-oriented permanent pacemaker information system are described. Extensive patient and pacer functional data are maintained in readily accessible files which may be displayed on a CRT terminal or printed out. Selective sorting of stored information may be accomplished according to any desired set of inclusive or exclusive criteria. Intelligent, comprehensive patient follow-up has been greatly facilitated through application of the system. In view of the rapidly expanding pacemaker population, it is suggested that cooperative regional networks operating with comparable information storage and retrieval structures will provide the only means for adequate patient surveillance and compilation of necessary pacemaker data.
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The full graphic capabilities of a minicomputer have been applied to rapid and versatile analysis of long-term electrocardiographic tape recordings. Interfaced to a standard Avionics tape analyzer, the system's multiple display options provide a powerful tool for arrhythmia detection in a reasonable amount of time. Detection accuracy of the system compares very favorably with previously published figures for computer EKG monitoring. Quantitation of arrhythmic beats is an integral feature of the tape scanning. A method for analog display of randomly selectable EKG complexes is also described.
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Cardiac output was assessed in 16 children without evidence of cardiovascular shunts from simultaneously recorded earpiece and cuvette densitometric tracings. The earpiece set-up was calibrated by the end-tail method. Both instruments gave linear response to dye concentrations used. There was a close correlation between cardiac output figures recorded by the two methods (r equal to 0.95) and no systematic difference occurred. It is concluded that in infants and children earpiece densitometry constitutes a rapid and accurate method for quantitative circulatory studies.
Various physiologic parameters were examined during submaximal and maximal treadmill exercise in nine members of the U.S. Nordic Ski Team prior to and following three months of on-snow ski training. In addition, four of this group were re-tested at the conclusion of the competitive skiing season. Results indicate a perceptible increase in training effect during the fall and early winter before starting on the European race circuit with subsequent decline in this effect as measured in the spring. It is suggested that this latter phenomenon occurs at least in part due to lack of adequate training time during the period of long-distance travel and racing.
Non-infiltrating (T1), and superficially infiltrating (T2), vesical neoplasms can be treated satisfactorily by transurethral resection. Some T3 neoplasms can be treated this way, but most will require radiotherapy. The assessment and treatment of 840 cases are presented. Survival rates of 62% in T1 cases, 59% in T2 cases, and 20% in T3 cases are reported in 465 cases followed up for 5 years.