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Biomedical subjects

J S Hermann

Publications and source records attributed to J S Hermann.

17 recordsLinked to original sources

Dehydroepiandrosterone sulfate, cholesterol, hemoglobin, and anthropometric measures related to growth in male adolescents.

Sixty-four white boys between 10.6 and 14.3 years old participated in an adolescent nutrition assessment study evaluating dehydroepiandrosterone sulfate (DHEAS) as a measure of maturation. DHEAS, an adrenal androgen, is low in childhood and rises with the development of secondary sexual characteristics. Biochemical measures included plasma DHEAS assessed by radioimmunoassay, cholesterol assessed by an enzymatic method, and hemoglobin assessed by the cyanmethemoglobin method. Midarm muscle area (MAMA) was calculated from midarm circumference and triceps fatfold measurements. DHEAS was correlated significantly with height, weight, MAMA, and hemoglobin. By age, significant differences were found for height, weight, and MAMA, but not for any of the biochemical measures. For boys with DHEAS concentration less than 3 mumol/L, values for height, weight, body mass index, MAMA, and hemoglobin were significantly different from those for boys with higher DHEAS concentrations. No significant differences were found for age or nutrient intakes by DHEAS concentration groups. Mean plasma cholesterol concentrations decreased with increases in age and with maturation evidenced by higher DHEAS concentration. Cholesterol concentration was negatively correlated with height and MAMA. Mean nutrient intakes estimated by a quantitative food frequency questionnaire met or exceeded the Recommended Dietary Allowances for these age groups. DHEAS identified maturation differences in male adolescents.

Adolescent

Paretic thyroid myopathy.

Reports of vertical deviation in Graves' disease in recent years have always been associated with restrictive phenomena and positive forced duction testing, usually related to a tight inferior rectus. Two cases of medically proven Graves' diseased of ten-year duration are presented with increasing vertical disparity. Forced duction testing showed no restriction. Saccadic velocity tests using electro-oculography confirmed paresis of the inferior rectus in both cases. No cases of "true" vertical extraocular muscle paresis in chronic Graves' disease have been reported in the American literature.

Adolescent

Acquired Brown's syndrome of inflammatory origin. Response to locally injected steroids.

In a recent large series of tendon sheath syndrome, Brown reported only five cases of the pure acquired type that were not intermittent and in which the patients did not undergo spontaneous recovery. The origin of acquired Brown's syndrome is varied and includes trauma of the orbit, direct trochlear trauma, orbital or muscle surgery, frontal sinusitis or sinus surgery, and inflammation of the superior oblique tendon and sheath, namely a stenosing tenosynovitis. The differential diagnosis and possible causes of the acquired Brown's syndrome were reviewed, and two cases of presumptive tenosynovitis of the superior oblique tendon and sheath are presented in detail. In both cases, the condition of each patient was notably improved by a series of direct injections of methylprednisolone acetate into the trochlear region. This form of treatment for acquired Brown's syndrome of inflammatory origin has never, to my knowledge, been reported in the literature.

Adolescent

Antipodean squint.

Strabismic cases which are exotropic fixing with one eye, and esotropic fixing with the other eye are rare and a result of anisometropia, unequal accommodation, paresis or restriction, and previous ocular muscle surgery. Three cases of antipodean squint are reported without known etiology factor. An extensive survey of experts in the field of strabismus was unable to document other similar cases where a cause could not be determined.

Accommodation, Ocular

Surgical therapy of convergence insufficiency.

Fourteen cases of intractable convergence insufficiency were surgically treated by resection of both medial rectus muscles. All 14 patients showed dramatic relief of severe asthenopic symptoms. Temporary diplopia due to consecutive esotropia is a necessary part of this surgery and is relieved by fresnel prisms. Exophoria at near will return, occasionally to the original angle of deviation, but the symptoms do not return. The preoperative symptoms can be of severity out of proportion to the deviation. Bimedial resection is a most efficacious surgical method for treatment of intractable convergence insufficiency.

Accommodation, Ocular

Masked bilateral superior oblique paresis.

Masked bilateral superior oblique paresis which was unsuspected occurred in 9 out of 57 cases. In every case of superior oblique paresis, bilaterality should be presumed until proven otherwise. Maximum attention on multiple examinations should be utilized to elicit the slightest contralateral inferior oblique overaction.

Adolescent