Light as a treatment for nonseasonal depression?
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Bipolar Disorder↗
Biomedical subjects
J S Kantor
Publications and source records attributed to J S Kantor.
Lithium ratio and maintenance treatment response.
Erythrocyte/plasma lithium ratios were determined in 41 polar manic depressive outpatients maintained on lithium for a mean of 64 months. Sixteen patients experienced affective episodes requiring additional pharmacologic intervention during periods when their plasma lithium averaged 0.7 meq/l or above for at least 3 preceding months and they were on no concurrent medication known to induce depression or mania. These patients considered to be a homogeneous group of non-responders to lithium, had a mean lithium ratio of 0.50 (range 0.15-1.16). Seven patients experienced affective symptoms at plasma levels below 0.7 meq/1 and/or while taking concurrent medication known to induce affective symptoms, and therefore could not be categorized clinically as lithium non-responders or responders. Eighteen remaining patients, who had no affective episodes during lithium maintenance, were found to have a mean erythrocyte/plasma ratio of 0.52 (range 0.19-1.05). This latter group of apparent responders should be considered heterogeneous in that it may include spontaneous remitters. The difference in mean ratios between the non-responder group and the apparent responder group was not statistically significant. These findings support the contention that the erythrocyte/plasma lithium ratio does not correlate with response of bipolar outpatients to maintenance lithium.
Bipolar Disorder↗
Mitral valve prolapse syndrome in agoraphobic patients.
Twenty-five agoraphobic women were compared with 23 controls for the presence of mitral valve prolapse syndrome (MVP). All subjects underwent cardiac examination, electrocardiography, phonocardiography, and echocardiography. Eleven of the agoraphobic patients had MVP; 5 had echo findings alone, 3 had both auscultory and echo findings, and 3 had auscultory findings alone. Two controls had evidence of MVP, both with echo findings alone. Echo chamber size and wall motion were similar in both groups. One patient had inferior T wave changes on ECG while all controls had normal tracings. The authors conclude that a significant number of agoraphobic patients have MVP and discuss the thoretical and clinical implications of this association.
Adult↗
Relationship between the B-mitten EEG pattern and tardive dyskinesia. A pilot control study.
The identification of patients at high risk for the development of tardive dyskinesia (TD) is a major problem in psychopharmacology. We found a possible relationship between the subcortical B-mitten EEG pattern and TD. Twenty-one TD pateints were matched on a number of relevant variables with 21 patients without TD. Ninety-five percent of the TD patients had mittens, compared to 33.3% of controls. The results suggest that the mitten dysrhythmia may be a risk factor for the development of TD. Additional findings suggest that among TD patients, mittens are differentially more frequent in younger (93.1%) as opposed to older (0.0%) subjects.
Adolescent↗