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Biomedical subjects

J S Legge

Publications and source records attributed to J S Legge.

65 records · Page 4Linked to original sources
PubMed1972

Effect of nitrazepam in chronic obstructive bronchitis.

The effect of nitrazepam on ventilatory capacity and arterial blood gas tensions was studied in a double-blind controlled crossover trial in six patients with chronic obstructive bronchitis in ventilatory failure (raised Paco(2)). Nitrazepam produced a fall in ventilatory capacity and worsening of the ventilatory failure. In the sixth patient, while on the active drug, the Pao(2) fell from 48 to 35 mm Hg while the Paco(2) tension rose from 59.5 to 68 mm Hg. It is suggested that nitrazepam is contraindicated in patients with severe chronic obstructive bronchitis.

Aged↗
PubMed1971

Comparison of two oral selective beta2-adrenergic stimulant drugs in bronchial asthma.

The effect of two oral selective beta(2)-stimulant drugs, salbutamol and terbutaline, on spirometry, arterial blood-gas tensions, pulse, and blood pressure was compared with placebo in a double-blind controlled trial in 12 asthmatic patients. Both drugs increased to forced vital capacity and the forced expiratory volume in 1 second equally for up to five hours, the maximal effect occurring at two to four hours. There was no significant change in arterial blood-gas tensions but both drugs increased pulse rate slightly. Tremor was the most common side effect. Terbutaline seems to be an effective alternative to salbutamol.

Adrenergic beta-Agonists↗
PubMed1970

Comparison of effect of salbutamol and isoprenaline on spirometry and blood-gas tensions in bronchial asthma.

The effect of the aerosol inhalation of 200 mug. of salbutamol and 1,000 mug. of isoprenaline on spirometry and blood-gas tensions was compared in the same 11 asthmatic subjects. Both drugs significantly reduced airway obstruction, and the extent of the reduction did not differ for periods of up to 30 minutes. After isoprenaline tachycardia and a small significant fall in arterial oxygen tension occurred, whereas after salbutamol there was no change in pulse rate and the arterial oxygen tension did not fall.

Adult↗