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J S MALPAS

Publications and source records attributed to J S MALPAS.

9 recordsLinked to original sources
PubMed1965

STUDIES ON THE SERUM IRON-BINDING CAPACITY.

The total iron-binding capacity of serum has been estimated using a colorimetric method, a radioisotopic technique, and a method employing immunodiffusion. The modified isotopic technique described was considered to be the method of choice. The total iron-binding capacity starts to increase at an early stage of an iron-deficiency anaemia. It is decreased in infectious and malignant disease. Close correlation exists between the level of saturation of the total iron-binding capacity and the haemoglobin level in patients with uncomplicated iron-deficiency anaemia. In patients with disease of the liver a difference was sometimes found between the total iron-binding capacity determined by the immunodiffusion method and by the two other techniques, the values with the immunodiffusion method being distinctly lower. This suggests the presence in the serum of iron which is not bound to transferrin. It is possible that ferritin was present in the serum in these cases.

Anemia↗
PubMed1964

CHANGES IN SERUM ALPHA-2 GLOBULINS IN RETICULOSES.

The total concentrations of alpha(2) globulin and two of its components, haptoglobin and caeruloplasmin, have been determined in the sera from 78 patients with primary malignant diseases of lympho-reticular tissue (reticuloses). The total alpha(2) globulin fraction was significantly raised only in Hodgkin's disease. The serum haptoglobin was also significantly increased in Hodgkin's disease and some other reticuloses, including acute leukaemia, lymphosarcoma, and reticulum cell sarcoma. The serum level of caeruloplasmin was raised in all reticuloses. There was possibly some correlation between the rise in haptoglobin and caeruloplasmin concentrations and the total alpha(2) globulin in Hodgkin's disease but this was not statistically significant. The significance of these results is discussed, and it is concluded that the increase in alpha(2) globulin which occurs in Hodgkin's disease is due to an increase in several of its components and not to a single component.

Alpha-Globulins↗