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Biomedical subjects

J S Murty

Publications and source records attributed to J S Murty.

At least 19 recordsLinked to original sources
PubMed1989

Genetic structure of three Naikpod subpopulations of Andhra Pradesh, India.

The genetic structure of three subpopulations of the Naikpod tribe of Andhra Pradesh, India, was examined by studying three blood group, six red cell enzyme, and five protein systems and phenylthiocarbamide taste sensitivity. The gene frequency data of 15 loci are compared among the subpopulations as well as with those reported for other population groups from India. The analysis of gene diversity revealed that the gene differentiation among the subpopulations relative to total population is only 0.02, indicating that the genetic differentiation between subpopulations is very small compared with that within them. This is corroborated by the small genetic distances found among them. The effect of differentiation of microgeographical and breeding isolation on gene diversity and genetic differentiation among the three subpopulations is apparently low.

Acid Phosphatase↗
PubMed1989

Segregation frequency in microcephaly.

A total of 118 cases of microcephaly were clinically evaluated under two main groups: primary microcephaly (61 cases) and secondary microcephaly (57 cases). Secondary cases were generally characterized by convulsions, spasticity, and other congenital anomalies. Estimates of segregation frequency obtained separately in primary and secondary cases indicated that the primary consanguineous cases were most probably due to a single recessive gene. The segregation frequency was substantially less in other types, indicating much lower genetic risks in these cases.

Consanguinity↗
PubMed1987

Serum levels of IgA in peptic ulcers.

A study of the IgA levels in 43 duodenal ulcer (DU) patients and 8 gastric ulcer (GU) patients and their comparison with healthy controls reveals significantly elevated levels of IgA in DU and somewhat lower levels in GU. The levels were also associated with the genotypes of the patients for genetic markers such as ABO blood group, ABH sectetor status, haptoglobin, and alkaline phosphatase enzyme. Nutritional factors, such as vegetarianism, chili consumption, and habits such as smoking and alcoholism also showed variation in the IgA levels. These results indicate the response and role of IgA in the immunological mechanisms involving mucosal protection and autoimmunity in ulceration processes in the stomach.

Duodenal Ulcer↗
PubMed1985

AB0 blood group incompatibility and inbreeding effects: evidence for an interaction.

It is known that consanguinity reduces the chances of maternal-foetal incompatibility but it is not known whether inbreeding influences the expression of the effects of such incompatibility. This paper investigates and finds evidence for an interaction between inbreeding and AB0 blood group incompatibility on the expression of neonatal mortality, sibship precocious mortality, neonatal jaundice, asphyxia, and sex ratio, through screening of 3923 consecutive newborns. Inbreeding and incompatibility individually showed variable effects on the above parameters, but their interaction was such that, in the presence of inbreeding, incompatibility reduced the incidence/relative risk of all the above factors. Such a uniform negative interaction was presumed to be due to homozygosity of some pleiotropic genes caused by inbreeding.

ABO Blood-Group System↗
PubMed1983

Association of genetic markers with some eye diseases.

In this study ocular conditions like cataract, corneal dystrophy, retinal detachment, primary glaucoma, myopia and strabismus have been examined for certain genetic markers to estimate the relative risks involved. The incidence of nontasters for PTC was significantly high in cases with congenital cataract, aphakic retinal detachment and convergent and divergent squint as compared to controls. Among nontasters, the frequency of total taste blindness was strikingly high in the disease group as compared to controls. Blood group A individuals showed significantly high risk for zonular cataract, corneal dystrophy and convergent squint; group B individuals for zonular cataract and group O individuals for nuclear cataract, myopia and convergent squint. There was a high preponderance of non-secretors in zonular cataract and primary glaucoma cases when compared to controls. The incidence of HbS (one case with primary glaucoma and the other with granular corneal dystrophy) and HbD (one case with senile cataract) were considered as chance occurrences. A strong association was found between Hp 2-2 and retinal detachments specially those with vitreous degenerations. In general, when compared to controls, the frequency of Hp 2-2 was relatively low in nuclear, zonular, cortical and senile cataracts, while it was high in rest of the diseases.

ABO Blood-Group System↗
PubMed1983

Digital dermatoglyphics in some tribal populations of Andhra Pradesh, India.

An analysis of digital pattern types, ridge counts and pattern intensity index was made on samples from six tribal populations viz. Koya, Kolam, Rajgond, Chenchu, Pardhan and sugali. Bimanual, sexwise and inter-tribal comparisons were made for all the six tribes. Males in Koya, Kolam and Sugali and females in Sugali showed significant bimanual difference (chi 2 values 10.44, 10.09, 9.74 and 10.71 respectively). Sex difference was significant in Rajgond, Chenchu and Pardhan (chi 2 values 19.26, 33.46 and 24.64 respectively) for frequency of digital patterns. Inter-tribal comparisons showed Koya resembling with Kolam and Pardhan and Rajgond with Pardhan. For Total Finger Ridge Count, Kolam showed similarity with Rajgond, Pardhan and Sugali, Rajgond with Sugali and Chenchu also with Sugali. Pattern intensity index did not differ significantly among these populations.

Adolescent↗
PubMed1981

Use of compound-probability distributions in the study of induced post-implantation dominant lethals.

The nature of the probability distribution of post-implantation dominant lethality was investigated in terms of the distribution of dead implants per female. It has been postulated that this distribution would be poisson in a control series of females but may follow a compound or a contagious distribution such as the beta binomial, negative binomial or Neyman type A in the treated series of females. The nature of these compound distributions for fitting mammalian mutagenicity has been examined. The implications of the results on the estimation of induced mutation rates are discussed.

Animals↗
PubMed1980

Dermal ridge configurations in retinal detachment.

An analysis of dermal ridge configuration in 95 retinal detachment patients showed characteristic association with different aetiological bases of the condition like myopia, aphakia, vitreous degeneration and idiopathic factors. The study revealed a significantly high frequency of whorls on fingers and low mean interdigital ridge counts in the patients as compared to controls. Aphakic detachments showed maximum and vitreous degeneration detachments minimum variation from controls for all characters except the main line terminations. Of all the parameters studied, main line terminations contributed maximum for the variation between the detachment types. The results are discussed in light of the contribution of dermatoglyphic characters to the aetiology of retinal detachment.

Adult↗
PubMed1979

Genetic studies on the Kolams of Andhra Pradesh, India.

A total of 220 persons belonging to the Kolam tribe in the Adilabad District of northwest Andhra Pradesh have been tested for 18 red cell eyzyme systems and for haemoglobin. Generally, the gene frequencies for the systems which showed electrophoretic variation were within the range for Indian populations; the gene frequency for AK1 is high by Indian standards and Hb AS is present. LDH Calcutta 1 was not detected in this population and a single example of PHI 2-1 was observed.

Acid Phosphatase↗
PubMed1977

Variation and inheritance of relative length of index finger in man.

The length of index finger relative to fourth finger has been measured on parents and children in 190 families belonging to an endogamous Reddy community of Nalgonda District, India. The distribution of relative index finger length among various family groups was unimodal and symmetric. Heritability estimates based on parent-offspring regressions indicate a moderate level (40--70 percent) of additive genetic variance. There was no evidence for the influence of sex-linked additive genes.

Adolescent↗