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Biomedical subjects

J S ROTH

Publications and source records attributed to J S ROTH.

At least 19 recordsLinked to original sources
PubMed1963

INHIBITION OF GROWTH OF CHICK EMBRYO BY INHIBITION OF DEOXYCYTIDYLATE DEAMINASE.

Deoxyguanylate when added to chick embryos grown in explant inhibited growth and development. Deoxycytidylate deaminase activity was inhibited both in the explants and in vitro; since the effect was quite specific, it is suggested that this may represent another control mechanism for deoxynucleotide synthesis.

Aminohydrolases↗
PubMed1962

Intracellular localization of enzymes in spleen. II. Some properties and the distribution of ribonuclease in rat spleen.

Some properties of rat spleen ribonuclease have been studied, and the intracellular distribution of the enzyme and ribonucleic acid have been presented. Spleen ribonuclease exhibits maximal activity at pH 5.8, and although there is some evidence for the presence of an enzyme with an optimum at pH 7.0, it is not conclusive. The enzyme is concentrated primarily in the mitochondrial fraction, but significant quantities occur in the supernatant fluid. The latter contains ribonuclease inhibitor similar to that found in liver. The effects of whole body x-irradiation, magnesium ion, substrate concentration, type of buffer, presence of p-chloromercuriphenylsulfonic acid, deoxycholate, and Triton X-100 on ribonuclease activity are examined.

Animals↗