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Biomedical subjects

J S Reif

Publications and source records attributed to J S Reif.

10 recordsLinked to original sources

A cohort study of canine testicular neoplasia.

A prospective epidemiologic study of canine testicular neoplasia was undertaken in the Philadelphia area in 1971, with the cooperation of private veterinary practitioners. By the end of 1975, 938 dogs had been monitored for an average of 2 years. The cohort consisted of 609 cryptorchid and 329 age- and breed-matched controls. The incidence of testicular neoplasia in the cryptorchid subcohort was 12.7/1,000 dog-years at risk. Testicular neoplasms did not develop in controls. A large proportion of the dogs were below the average age at onset for this neoplasm. Among dogs over 6 years of age, the incidence was 68.1/1,000 dog-years at risk. The incidence of Sertoli cell tumors and seminoma was approximately twice as high in dogs with unilaterally retained inguinal testicles as in abdominal cryptorchids. Sertoli cell tumors developed in 10 dogs and seminoma developed in 6. One half of the testicular neoplasms that developed did so within the first year of observation. This study demonstrated the feasibility of conducting prospective epidemiologic studies of canine diseases with the assistance of practicing veterinarians.

Animals

Natal patterns among registered dogs in the United States.

Breed, geographic, and seasonal distributions of canine births registered with the American Kennel Club for the years 1971 to 1973, accompanied by litter size and sex ratio data, were studied. A few breeds accounted for a large portion of the births. The breed distribution of births changed as popularity of various canine types waxed and waned. The geographic distribution of births generally paralleled the pattern of human population and was relatively stable. A distinct, repetitive seasonal distribution of births was evident. Human intervention probably molded much of this pattern, but genetic factors and environmental conditions also were involved. Litter size and sex ratio varied primarily with breed rather than with region or season and hence appeared genetically based.

Animals

Seasonality, natality and herd immunity in feline panleukopenia.

Feline panleukopenia (FPL) was diagnosed in 185 of 7043 feline admissions (2.63%) at a university veterinary hospital over an eight-year period. FLP has a distinct seasonal pattern, occurring during July, August and September. Seasonal peaks were noted in all the years studied. Cats less than one year of age accounted for 70% of the total morbidity. The birth of felines in the United States also assumes a distinctly seasonal pattern. Analysis of 47,786 purebred litters born during 1970-1972 revealed a peak during April, May and June with a national median of May 29. A unifying hypothesis is presented to account for the seasonal occurrence of FPL. An influx of susceptible cats occurs annually following the birth of large numbers of kittens each spring, and disappearance of maternal immunity during the next two to three months. The addition of a large number of susceptible kittens leads to the development of summertime epidemics and serves to exemplify the principles of "herd immunity."

Animals