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Biomedical subjects

J S Shilling

Publications and source records attributed to J S Shilling.

9 recordsLinked to original sources
PubMed1991

Neovascular response in ischaemic central retinal vein occlusion after panretinal photocoagulation.

Twenty seven eyes treated for ischaemic central retinal vein occlusion with panretinal photocoagulation were reviewed. Prior to laser therapy anterior segment neovascularisation predominated (17 eyes) over posterior segment involvement (6 eyes). After photocoagulation anterior segment new vessels regressed or did not develop in the majority of cases. However, in five eyes previously absent posterior segment neovascularisation occurred. These results suggest that photocoagulation alters but does not eliminate retinal ischemia, thus modulating the neovascular response.

Aged↗
PubMed1987

Neovascularisation associated with posterior uveitis.

Twenty-six patients (39 eyes) with retinal neovascularisation associated with ocular inflammation were identified from the retinal vasculitis clinic at St Thomas's Hospital. Eight patients had sarcoidosis, seven patients Behçet's disease, and 11 had idiopathic retinal vasculitis. Twenty-three patients had required systemic therapy to control the inflammation and 11 patients received laser photocoagulation. Fluorescein angiography showed significant capillary closure in 15 eyes and diffuse microvascular leakage in the remaining 24 eyes. All patients had posterior vitreous detachment. The visual prognosis was good despite vitreous haemorrhage being the presenting feature in 22 eyes, and the new vessels resolved in 70% of cases. However, laser treatment was followed by a significant increase in cystoid macular oedema (p less than 0.01). This retrospective study suggests that medical therapy is the first line of treatment in this group of patients. Photocoagulation should be performed when the eye is quiet and should be reserved for patients with recurrent vitreous haemorrhages and significant capillary closure.

Adolescent↗
PubMed1976

Vascular changes after retinal branch vein occlusion.

I have described the vascular changes after retinal branch vein occlusion and have shown progressive changes both in the large retinal vessels and in the capillary bed. The capillary reactions are comparable to those seen in central retinal vein occlusion. Retinal oedema due to capillary dilatation and leakage occurs in both conditions but, whereas this is generalized in central retinal vein occlusion, local changes occur in branch vein occlusion. Capillary closure also occurs in both conditions, but the neovascular response differs. In branch vein occlusion significant new vessel formation is restricted to the retina leading to recurrent vitreous haemorrhage. This contrasts with central retinal vein occlusion in which thrombotic glaucoma due to predominantly anterior segment neovascularization is the most serious cause of visual loss.

Fluorescein Angiography↗