Potentiation of the behavioral and convulsant effects of cocaine by chronic administration in the rat.
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Animals↗
Biomedical subjects
Publications and source records attributed to J S Stripling.
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Tolerance and physical dependence was produced in C57Bl/6 male mice that had been exposed, for 36 days, to methaqualone in food pellets via an automated system. Tolerance was revealed in the reduction of sleep-times following intraperitoneal injection of methaqualone. Physical dependence was manifested as an alteration in neural sensitivity to flurothyl-induced convulsions.
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