Prognosis after donor nephrectomy: an update.
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Biomedical subjects
Publications and source records attributed to J S Tapson.
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A 52-year-old man, who had undergone donor nephrectomy 14 years previously, recently developed end-stage renal failure himself. The recipient of the donated kidney still has normal renal function associated with marked proteinuria. This deterioration of kidney function emphasizes the need for meticulous pre-operative evaluation of potential kidney donors and for the long-term post-operative follow-up of the donor as well as the recipient.
The glomerular filtration rates of 28 subjects, who had undergone donor nephrectomy up to 22 years previously, were measured before and after ingestion of an 80 g protein meal. A renal functional reserve was demonstrated in all cases. There was no evidence of loss of this reserve with time after nephrectomy. This study supports the view that long-term compensatory hyperfiltration of the remaining kidney after donor nephrectomy is not damaging, at least over this time scale.
Fungal infection is an uncommon cause of peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD). This report describes the clinical and microbiological features of 10 cases of fungal peritonitis. Although all patients survived, morbidity was high. Abscess and adhesion formation were particular problems. Only two patients were able to return to CAPD after microbiological cure. Currently available treatment strategies for fungal peritonitis are reviewed.
Renal length was measured radiographically in 65 living kidney donors, aged 27-69 years, who had undergone unilateral nephrectomy during the past 20 years. In 34 of these subjects, pre- and post-operative kidney length, glomerular filtration rate (GFR) and blood pressure were available for analysis. Male donors developed greater compensatory hypertrophy than female donors. The extent of renal enlargement correlated negatively with the age of the subject at the time of nephrectomy and with the current mean arterial blood pressure. However, no correlation was found between the percentage change in renal length and either GFR or time since nephrectomy.
A questionnaire, designed to determine the current habits of British nephrologists regarding temporary vascular access for hemodialysis, was sent to 62 renal units. Forty-six (74%) completed questionnaires were returned. Cannulation of the subclavian vein with a single-lumen catheter is the most popular technique. There is only limited use of double- or dual-lumen catheters in the United Kingdom. Previously unreported fatal complications of subclavian hemodialysis catheters are described.
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Pre- and post-nephrectomy renal function and blood pressure were compared in 75 subjects who had donated a kidney for transplantation during the past 20 years. The function of the remaining kidney was not adversely affected by prolonged compensatory hyperfiltration. However, an increased prevalence of hypertension was found in 'long-term' kidney donors.
The dual lumen catheter has recently been developed as a subclavian vascular access device for haemodialysis. This paper describes our preliminary experience with two currently available catheters of this design: the Shiley Dual Lumen Catheter, and the Quinton-Mahurkar Dual Lumen Catheter. The performance of both catheters, characterised by high blood flow rate capabilities, low venous resistances and minimal recirculation, is superior to that of other types of subclavian haemodialysis cannula.
A 19-year-old woman died when a subclavian catheter that had provided vascular access for plasmapheresis penetrated her right atrium, pericardium, and parietal pleural, causing a hemothorax. Precautions are recommended to minimize the risk of this complication in patients in whom subclavian catheters are used as a vascular access route for hemodialysis or plasmapheresis.
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Primary cytomegalovirus infection in the patient who is receiving immunosuppression therapy is associated with a high morbidity and mortality. We report a patient who developed primary cytomegalovirus infection 37 days after heart transplantation with a rapidly deteriorating course. Treatment with the new antiviral drug trisodium phosphonoformate (Foscarnet-Astra) was initiated as a lifesaving measure with rapid, dramatic improvement in the patient's condition and subsequent recovery.