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Biomedical subjects

J S Templeton

Publications and source records attributed to J S Templeton.

5 recordsLinked to original sources

Azapropazone and renal function.

Renal concentrating ability was measured in two groups of arthritic patients. The first had received long-term therapy with azapropazone and the second with other nonsteroidal anti-inflammatory drugs. Even after long periods of treatment, azapropazone did not adversely affect renal concentrating ability.

Adult

Comparison of azapropazone and naproxen in rheumatoid arthritis.

A double-blind crossover trial was carried out in 15 patients with definite rheumatoid arthritis to compare the effectiveness of 1200 mg azapropazone daily and 750 mg naproxen daily, each drug being given for 2 weeks. Patients also received placebo therapy before and between the two treatment periods. The results of subjective and objective assessments showed that both drugs were significantly superior to placebo, but no significant difference could be demonstrated between the two drugs.

Adolescent

A comparative trial of azapropazone and ketoprofen in the treatment of acute backache.

A double-blind trial of azapropazone (300 mg. 4-times daily) and ketoprofen (50 mg. 4-times daily) was carried out in 50 patients with acute backache sufficiently severe to necessitate hospital admission. Of 39 patients who completed the full 3-weeks' study period, 18 preferred azapropazone therapy, 10 preferred ketoprofen, and 11 showed either preference for the intermediate placebo period or no preference at all. Ten patients suffered from sufficiently severe side-effects with ketoprofen to necessitate their withdrawal from the trial. There were no similar episodes of withdrawal occurring during the azapropazone period.

Acute Disease