Biomedical subjects

J S Urbanetti

Publications and source records attributed to J S Urbanetti.

4 recordsLinked to original sources

PubMed1981

Carbon monoxide poisoning.

Carbon monoxide (CO) is a ubiquitous toxin that may reversibly bind various heme-containing proteins in the human body. These proteins (hemoglobin, myoglobin, cytochrome P450, cytochrome oxidase) may be bound by the CO at sites which are also responsible for O2 transport. Since the CO-heme bond is less dissociable than the O2-heme bond, severe disruption of normal O2 transport may occur. A tissue hypoxia may result causing transient or permanent damage that may appear as clinical abnormalities. Since the clinical effects of exposure are the result of local hypoxia, they tend to appear in the more oxygen dependent tissues such as the brain and heart. Specific treatment for the exposure consists of restoring O2 supplies to the deprived tissues and supporting the patient through the short and long term sequellae of the hypoxia. Since a wide variety of CO sources may cause the intoxication and the clinical presentation may mimick other diseases, medical personnel must be alert to this relatively common illness.

Animals↗

PubMed1980

Metastatic endotracheal tumor from ovarian carcinoma.

This report describes a patient with acute airways obstruction and respiratory failure secondary to a large endotracheal metastasis from a primary ovarian carcinoma first detected seven years previously. Associated airflow obstruction due to mucus impaction contributed significantly to the development of respiratory failure. The tumor responded to radiotherapy, and radiologic evidence for tracheal obstruction was no longer present five months after irradiation.

Cystadenoma↗

PubMed1979

False negative biopsy in Pneumocystis carinii pneumonia.

Unlike most pneumonias, the diagnosis of Pneumocystis carinii pneumonia is based solely on identifying organisms by stain, usually with methenamine-silver. Because of technical problems involved with adequate staining, control samples usually are done concurrent with tissue specimens to be examined. Lung containing fungi often is used as a control. We recently observed false-negative biopsy specimens in a case of P carinii pneumonia where the Pneumocystis organism failed to stain with methenamine-silver on several occasions, although fungal controls were positive. This report emphasizes the importance of using P carinii as a control whenever attempting to diagnose P carinii pneumonia.

Adult↗

PubMed1976

Exercise tolerance at 4 and 6 ATA.

Seven normal male subjects performed 5-min bicycle exercise ranging from 50-100% maximum oxygen uptake at 4 ATA and three were also studied at 6 ATA. At all pressures, the subjects breathed 0.2 ATA O2 plus nitrogen. All subjects were able to perform maximum work at all pressures. No pressure-dependent variations in heart rate, O2 uptake, or CO2 output were noted. At both 4 and 6 ATA, ventilation was decreased at exercise levels greater than 80% maximum O2 uptake. The magnitude of the decrease was not great, however, and signified only minor CO2 retention. In some instances exercise ventilation closely approached the 15-S maximum breathing capacity and these subjects noted severe dyspnea, possibly due to dynamic compression of large airways. In three subjects, respiratory frequency was measured as well as minute ventilation; this relationship did not change with depth. Subjects performing heavy exercise at 6 ATA noted disturbances of consciousness, presumably due to N2 narcosis.

Adaptation, Physiological↗