Bladder cancer and N-methyl-N-nitrosourea. II. Sub-cellular changes associated with a single noncarcinogenic dose of MNU.
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Biomedical subjects
Publications and source records attributed to J S Wakefield.
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A case of the rare solid and cystic papillary tumor of the pancreas in a young woman is described. The diagnosis was made by fine needle aspiration cytology, with electron microscopic examination of the needle washings. The preoperative cytologic diagnosis enabled appropriate surgical treatment to be planned and carried out without undue delay. It is important to distinguish this rare tumor from other pancreatic tumors with similar cytohistologic features since, if diagnosed correctly and managed surgically, this neoplasm is associated with a good prognosis.
The protective effect of GIK infusion on the ischaemic myocardium was assessed by isovolumic function tests and electron microscopy. There were two control groups, group 1 hearts underwent 2 hours of continous normothermic cross-perfusion and group 2 hearts endured 2 hours of ischaemia. Group 3 hearts were administered GIK solution prior to ischaemic arrest. The group 3 hearts showed less loss of contractile force and contractile velocity from the ischaemic period compared to group 2 hearts, but no benfit was shown in terms of compliance. Electron microscopic examination showed slightly less damage in the group 3 hearts compared to group 2 hearts. Group 1 hearts maintained better function than either of the other two groups. Ultrastructure was not examined in group 1 hearts. A slight protective effect of GIK on the ischaemic myocardium was thus confirmed.