Biomedical subjects

J S Werry

Publications and source records attributed to J S Werry.

At least 91 records · Page 5Linked to original sources

PubMed1975

The effects of methylphenidate and haloperidol on the heart rate and blood pressure of hyperactive children with special reference to time of action.

Twelve hyperactive-aggressive children were given single acute doses of placebo, methylphenidate (0.3 mg/kg) and haloperidol (0.035 mg/kg) on three separate occasions in a double blind crossover design with drug order randomized across subjects. Resting heart rates and systolic and diastolic blood pressures were obtained at nine intervals up to 7 hrs and electrocardiograms at 150 min after ingestion. Methylphenidate caused a small trend toward an increment in heart rate and a significant increment in blood pressure, while the changes with haloperidol were minimal. There were no EKG changes. Changes in heart rate were of a minimal nature as compared with those occurring with digestion which tended to obscure drug effects.

Analysis of Variance↗

PubMed1975

Methylphenidate and haloperidol in children. Effects on attention, memory, and activity.

Twenty-four hyperactive or unsocialized-aggressive children participated in an exploratory double-blind crossover study comparing the cognitive effects of methylphenidate hydrochloride (0.3 mg/kg), two doses (0.25 and 0.05 mg/kg) of haloperidol, and inert placebo. Each subject received each of four drug conditions, drug order being randomized by a Latin square design. At the end of each 18-day trial period, attention, immediate recognition memory, reaction times, and seat activity were tested. While drug effects were small, methylphenidate and, to a lesser extent, the low dose of haloperidol, facilitated performance, whereas there was some suggestion that the high dose of haloperidol may have caused a slight deterioration in performance. These results are contrasted with effects on social behavior where the latter improved behavior. No differences attributable to diagnosis were found.

Aggression↗

PubMed1975

Conners' Teacher Rating Scale for use in drug studies with children--an empirical study.

Their classroom teachers rated 291 schoolchildren, grades kindergarten through 6, on Conners' Teacher Rating Scale, developed for and used widely in drug studies in children. Scores were found to be significantly lower than those reported for a similar group of 92 New York children and considerably less than those of a group of 64 children receiving medication for deviant behavior. Boys generally had higher scores for acting-out-type behavior while girls scored higher on neuroticism. The factor structure in this sample showed some differences from that in Conners' original analysis but they are insufficient for any change in the widely accepted scoring system, except perhaps to add a fifth factor of sociability.

Acting Out↗

PubMed1975