Biomedical subjects
Publications and source records attributed to J Sałabun.
Histamine restored spontaneous activity in the isolated rabbit sinus node arrested with reserpine. This fact suggests that catecholamines are not the unique activators of adenylate cyclase required for cardiac pacemaking, and may be replaced by histamine.
Adenosine abolished action potentials and slowed down depolarization in the sinus node cells, and depressed the slow component in the working fibers. Noradrenaline and dibutryl cAMP did not counteract the effects of adenosine in the working myocardium whereas in the pacemaker, dibutryl cAMP alone evoked low frequency spontaneous activity.