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Biomedical subjects

J Sade

Publications and source records attributed to J Sade.

At least 19 recordsLinked to original sources
PubMed2000

Exostoses and cavernous venous formation in the external auditory canal of the hooded seal as a functional physiological organ.

Exostoses of the external auditory canal (EAC) develop after protracted mechanical, chemical or thermal irritation in particular. This is a common disorder among aquatic sportsmen and has been considered unique to Man. We dissected and photodocumented the EACs of 5 newborn and 3 adult Hooded Seals (Cystophora cristata). Serial sections of the EACs were prepared for light microscopic evaluation after staining with haematoxylin-eosin or toluidine blue. All EACs exhibited a firm, broad-based. mountain peak-shaped exostosis on the floor of the meatus, lateral to the eardrum. In addition, the meatal skin of the bony EAC harboured large venous sinuses. The exostosis and venous sinuses of the seal EAC participate in the protection of the sensitive hearing apparatus, particularly the pars tensa portion of the drum, during divine.

Animals↗
PubMed1998

Quantitative analysis of gas losses and gains in the middle ear.

Quantitative analysis of the amount of gas entering and leaving the middle ear (ME) was performed in patients with central perforation or with ventilating tubes. Patients were divided into a 'balanced pressure group' (BP) where pressure remained close to atmospheric throughout the measuring period and an 'unbalanced pressure group' (UBP) where pressure decreased continuously throughout measurements. The rate of gas gain was 41.0 +/- 19.9 microl/h (mean +/- SD, n = 17) in the BP group, significantly higher than in the UBP group (21.4 +/- 9.6 microl/h, n = 8). The rate of gas loss was 34.8 +/- 17.7 and 36.1 +/- 15.9 microl/h in the BP and UBP groups, respectively. Deglutition frequency was 27 +/- 13.4 deglutition/h in the BP group, significantly higher than the deglutition frequency of the UBP group (16 +/- 8.9 deglutition/h). It seems that the amount of gas entering the ME per deglutition is rather stable and does not change significantly with ME pressure level. Negative ME pressure may result from decreased gas gain rate due to increased intervals between deglutitions and loss of interdependence between the rate of gas entering and leaving the ME.

Adolescent↗
PubMed1996

Gas composition of the human nose and nasopharyngeal space.

Since it was established that middle ear (ME) gas composition is closer to venous gas composition than to air, the question arose regarding the composition of gas which enters the ME from the nasopharynx. Using a mass spectrometer, gaseous partial pressure was measured at three locations in the nose and nasopharynx of 6 volunteers. All three locations showed similar gas composition (O2 = 15.7%, CO2 = 4.5%, N2 + Ar = 79.8%) which is similar to expired air. The gas that enters the ME via the Eustachian tube is a mixture closer to the final ME gas equilibrium than is air. This minimizes the changes in steady state ME gas composition incurred by gas influx into the ME.

Air↗
PubMed1992

Middle ear gases.

The ex vacuo theory, claiming that air enters the middle ear through the Eustachian tube and oxygen leaves it into the blood by diffusion, does not provide a complete explanation and description of the mechanism of middle ear aeration. This study shows that both the gas diffusion between the middle ear and the blood and the flow of gas through the Eustachian tube are bidirectional processes for all the gases concerned N2, CO2, O2 as well as H2O.

Adolescent↗
PubMed1991

Induced atelectasis of the middle ear and its clinical behavior.

Atelectatic ears are often treated with ventilating tubes for long periods of time. However, a certain percentage of atelectatic ears and retraction pockets resolve spontaneously over time. In order to determine whether self-aeration had been achieved in atelectatic ears previously fitted with ventilating tubes, the tubes were sealed and the ears were then closely followed. Out of 37 such tests, atelectasis did not recur in 4 ears, allowing their ventilating tubes to be removed. In 33 tests atelectasis redeveloped within 1-2h after the ventilating tube was sealed, with ears reverting to the same degree and shape as the original atelectatic condition. The seals were then removed, resulting in resolution of atelectasis. These observations were enforced by previous observations of similar changes and suggest that the partial pressures of the blood gases may be an important factor in controlling the level and possibly also the pathogenesis of atelectasis. The method of testing described also can be used in selected cases to determine whether or not a given atelectatic ear still requires a ventilating tube.

Acoustic Impedance Tests↗
PubMed1990

Cavernous hemangioma of the frontal bone.

A 61-year-old female presented with a tumor of her left superior orbital rim, which caused blepharoptosis and slight displacement of the globe. X-ray films showed a lytic defect in the frontal bone, while a computed tomography revealed the tumor to extend along the orbital roof, as well as to involve the posterior lamina of the frontal bone. A biopsy taken from the tumor showed it to be an intraosseus cavernous hemangioma.

Female↗
PubMed1989

Histopathology of the soft parts in 50 patients with malignant external otitis.

Reports concerning the lesions of the skin coverage of the external ear canal in malignant external otitis (M.E.O.) are very few. To evaluate this problem, we studied the skin lesions of 45 skin biopsies from 40 M.E.O. patients, 23 from regions covering the osseous part of the ear structure, seven from the cartilaginous part of the external canal and 15 from both parts. The epidermis was normal in nine, thickened in 16, with acanthotic thickening and pseudoepitheliomatous hyperplasia in 20. In the dermis the amount of collagen was normal, but it was infiltrated by the inflammatory process. Acute inflammation was observed in 16 biopsies, subacute in 23, chronic in six. A mixture of acute and chronic changes was present in 18 biopsies. No major abnormalities of the vasculature could be detected. The distinguishing pathological feature of M.E.O. concerns the typical topographic distribution of the inflammation in the osseous part of the external ear canal.

Ear Canal↗
PubMed1988

Complications of submucous resections of the nasal septum.

We studied retrospectively 263 patients, who had previously undergone submucous resection of their nasal septa. Unsatisfactory septal corrections, perforations, and dorsal saddling were looked for and could be correlated with the skills of the ten surgeons who performed the procedures. Three of the surgeons were attending physicians, while the other seven were resident trainees at different stages of their specialty education. From the total number of the patients, 17 (6.4%) were noted to have persistent septal perforations, 10 (3.8%) had residual deviations of their nasal septa, and 1 (0.4%) had a saddle nose deformity. These findings differed significantly among the different surgeons. The incidence varied from 0% to 30.4% in septal perforations, from 0% to 10.4% in unsatisfactory corrections of the septum, and from 0% to 2.6% in saddle nose. Our findings show that a well-executed submucous resection of the nasal septum by a skilled surgeon yields a low incidence of complications, while in unskilled hands, it may carry a high incidence of complications.

Adolescent↗
PubMed1982

The missing stapes and the Tabor prosthesis.

This is a description of a new stapes replacement prosthesis (SRP), which we term "Tabor". The prosthesis has two parts--the lower part is made of a broad inorganic, biocompatible material (Teflon) base, which fits and covers most of the footplate, ensuring maximal stability. The upper part of the prosthesis is made of autograft or homograft bone--usually a malleus head, the contact of which with the drum prevents extrusion. Eleven out of 12 ears operated with this prosthesis were successful--the average postoperative air conduction going up 33 dB (15-50), leaving an average of 18 dB (5-30) air-bone gap. The bone conduction also improved, from an average of 21 dB (10-30) to an average of 14 dB (10-25).

Bone Transplantation↗