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Biomedical subjects

J Sagristá Sauleda

Publications and source records attributed to J Sagristá Sauleda.

8 recordsLinked to original sources

[The clinical practice guidelines of the Sociedad Española de Cardiología on pericardial pathology].

The pericardium is a serous membrane consisting of two layers (parietal and visceral), which may be involved by different infectious, physical, traumatic, or inflammatory agents as well as in metabolic or systemic diseases. The reactions of the pericardium to these insults result in rather nonspecific clinical features, such as the characteristic inflammatory findings in acute pericarditis, the development of pericardial effusion with the possible complication of cardiac tamponade, and a fibrous retractile reaction that may lead to constrictive pericarditis. These phenomena are not mutually exclusive and can be simultaneous or consecutive in the same patient; however, for the sake of clarity they are independently discussed. The aim of the present guidelines is to provide orientation about the management of patients with pericardial disease. Such management should basically rest on the knowledge of the clinical and epidemiological features (such as disease frequency) of the different types of pericardial disease that determine the diagnostic and therapeutic yield of the different invasive pericardial procedures (pericardiocentesis, pericardial biopsy and pericardiectomy), and, therefore, their respective indications. In addition, the indication of the different types of medical therapy are discussed. On the other hand, emphasis is made on the possible limitation of the validity of these guidelines for patients belonging to geographical areas or socioeconomic contexts with different etiologic spectra.

Cardiology↗

[An analysis of the responses to the tilt-table test depending on the clinical characteristics of the syncopal episodes in patients without apparent cardiopathy].

Seventy-six consecutive patients were evaluated to assess whether the response to head-up tilt test was related to the type of clinical presentation in patients with syncope of unknown origin and free from heart disease. The syncopal attacks were clinically characterized in a prospective fashion before the tilt test. In 44 patients (group I) syncope had been preceded by autonomic symptoms or was associated with recent or static sustained orthostatism. In 32 patients (group II), syncope had been sudden, without prodromal or autonomic symptoms. Mean age was 49 +/- 17 years in group I patients and 47 +/- 17 years in group II patients (NS). The degree of tilt was 75 degrees. During 30 min no drugs were administered, and then isoproterenol was infused for an additional 20 min (1-5 micrograms/min until a maximal heart rate of 140 bpm was achieved). Tilt test was considered as positive when the patient developed syncope or presyncope with hypotension. Tilt test was positive in 33 patients from group I (75%) and 12 from group II (37.5%)(p = 0.001). The positive response developed within the 30 initial min of the test (without isoproterenol infusion) in 19 of 33 patients from group I (57%) and in 3 of 12 patients from group II (25%) (p = 0.053). It is concluded that the response to tilt test is related to the clinical features of syncopal attacks.

Adult↗

[Myocardial damage caused by electrical cardioversion].

The possible myocardial injury induced by electrical cardioversion in the treatment of supraventricular arrhythmias was analyzed after 45 countershocks of 200 joules and after 6 of 600 joules (total accumulated energy). In all patients myocardial injury was evaluated by serial CK, CK-Mb, and myoglobin determinations and in 48 cases a cardiac gammagraphy with technetium pyrophosphate was also performed. Significant increases in total CK and myoglobin were observed in 2 (4%) patients treated with 200 joules and in 3 (50%) patients receiving 600 joules. CK-Mb was also increased in one patient receiving 200 joules (13.5 U/I) and in one patient treated with 600 joules (27.8 U/I). In all cases technetium gammagraphy was negative.

Adult↗

[Electrical cardioversion after quinidine administration].

The aim of the present study was to investigate the influence of quinidine on the effectiveness of electrical cardioversion (CV) for the reversion of supraventricular arrhythmias, the amount of electrical energy necessary for the CV and the possible complications of electrical CV. Initially, 100 CV procedures were allocated to the control group (patients free from the action of any antiarrhythmic drug), and 50 CV to the quinidine group. Quinidine was given as dihydroquinidine C1H at a dose of 500 mg/12 hours since the day before CV. In the last group, 6 (12%) patients reverted to normal sinus rhythm before electrical CV. At the time of electrical CV (100 procedures in the control group and 44 in the quinidine group), the patients who received quinidine required a lower amount of electrical energy, and showed a lower incidence of atrial premature beats as compared with the control group (11.3% versus 28%, p less than 0.05). A similar proportion of patients reverted to sinus rhythm in both groups. We conclude that the administration of quinidine before electrical CV has the following advantages: 1) 12% of patients reverted to normal sinus rhythm before electrical CV; 2) quinidine reduced the amount of electrical energy necessary for the CV, and 3) quinidine reduced the incidence of atrial premature beats after electrical CV. On the other hand, quinidine had no influence on the incidence of ventricular arrhythmias after electrical CV.

Adult↗