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Biomedical subjects

J Saier

Publications and source records attributed to J Saier.

At least 19 recordsLinked to original sources
PubMed1977

[Effect of chlorimipramine on the so-called ponto-geniculo-occipitalactivity (PGO) in a primate, Papio hamadryas (author's transl)].

Three hamadryas adult baboons (female) received 24 daily injections of Chlorimipramine (1.7 mg/kg). The effects on sleep were nearly identical with the effects observed in man. PGO activity, recorded in the lateral geniculate nucleus, was much disturbed. The total number of PGO fell downward from the first recording. The number of PGO/min during paradoxial sleep was even more decreased. This fact suggests a selective influence of CL I on the mechanisms of PGO activity. Is the particular effect of importance to the treatment of depression symptoms?

Animals↗
PubMed1977

[Alterations of sleep caused by acute and chronic adminstration of lithium].

The sleep of 2 groups of subjects receiving lithium was studied. Ten normal controls after 17 days of lithium had a significant decrease of Paradoxical Sleep duration, with an increase of PS latency. A second group of 10 manic-depressive patients had received lithium for 22 +/- 6 months when they were recorded. They had a greater amount of slow wave sleep than the control group before lithium but the difference of PS duration was only related to a first night effect. Therefore sleep changes induced by lithium are different according to the duration of lithium administration. In any case they are less important than those induced by most of the anti-depressants.

Adult↗