Biomedical subjects
Publications and source records attributed to J Sandegård.
Ninety-two intra-articular ankle fractures were randomly selected for either open reduction and internal fixation or closed reduction and plaster cast. The patients were followed for an average of seven years. The initial course was more favorable in surgically reduced fractures. However, follow-up examinations showed little difference in results between the two forms of treatment.
The uptake of in vivo labeled Tc-99m RBCs and In-113m transferrin was studied in femoral bone of 21 patients who had recent operations for fracture of the femoral neck. Femoral bone biopsies and blood samples were obtained during the operation. The activity values for bone biopsies, erythrocytes, and serum were determined, and the uptake ratios between bone and erythrocyte cpm/g and between bone and serum were calculated. Biopsy samples were taken from the femoral head in 21 cases and from the trochanteric region in 14. The activity ratios for the two tracers correlated well: r = 0.94 for femoral head biopsies (P less than 0.001) and r = 0.98 for samples from the trochanteric region (P less than 0.001). Thus, the procedures are interchangeable and either may be valuable in assessing bone blood supply. An additional patient, studied only with Tc-99m RBCs, had a subsequent operation for nonunion of a fracture. Samples of both cancellous and cortical bone were obtained from the removed head. The activity ratios for the two types of bone tissue differed significantly (P = 0.02).
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Circulatory changes following standardized compression trauma to the hind leg in dogs were evaluated using an electromagnetic flow meter and repeated angiography. A transient increase of flow to the injured limb and within the traumatized region was observed. Good agreement was found between the electromagnetic flow recordings and estimates of relative changes in flow by the angiographic method.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A cross-infusion model including two dogs was used. At intervals 20 ml of blood from the iliac vein of one dog (donor), was injected during 60 sec into the iliac artery in which flow was measured electromagnetically in another dog (recipient). 1 min after missile trauma of the hind leg of the donor, the withdrawn venous blood possessed strong dilator property, manifesting itself by a transient, significant increase of blood flow in the registered artery of the recipient. This dilator property of venous blood from the traumatized region was, however, only apparent following wounding by missiles of high velocity.
Early hemodynamic and angiographic effects after fracture with a minimum of soft tissue injury were investigated in anesthetized dogs. A close relation between hemodynamic and angiographic findings was observed. The fracture procedure did not change the regional blood flow in the soft tissues outside the bone in the injured extremity.
The early circulatory changes following extensive soft tissue injury to the hind leg of the dog was examined by angiography and by measurement of blood flow by an electromagnetic flowmeter. The trauma caused a marked increase of blood flow and vasodilatation in the injured extremity with or without combination of a fracture. The later gradual increase of calculated vascular peripheral resistance was angiographically reflected by successively impaired flow in peripheral arteries. In spite of the decrease of flow, the dilatation of the larger arteries persisted for several hours.
The effects of repeated intraarterial injections of methylglucamine metrizoate on regional circulation were registered in soft tissue trauma to the dog hind leg. The circulatory disturbances were determined by hemodynamic measurements and by angiography. The changes of flow following injection of the contrast medium were related to the films. The informative arterial phase appeared in the time lag between injection and the flow increasing effect of the contrast medium both before and after trauma. No evidence of a cumulative effect was recorded.
The early circulatory changes following high velocity missile wounding to soft tissue of an extremity were analysed by hemodynamic methods and serial angiography. The extent of the tissue injury and the functional disturbances were mapped out and the time-course of the alterations in blood flow was registered. Possible mechanisms for the observed abnormalities are discussed.
The dilatation of major arteries following early after extensive soft tissue trauma was demonstrated angiographically not to be affected by pharmacologic or mechanical contractile stimuli. The proximal spread of the dilatation was not abolished by the division and a reanastomosis of the vessel before the trauma. These results suggest loss or impairment of the contractile ability of the major arteries following early after the trauma.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.