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Biomedical subjects

J Sandelin

Publications and source records attributed to J Sandelin.

8 recordsLinked to original sources
PubMed1992

Mechanical failures of internal fixation in T and Y fractures of the distal humerus.

To evaluate the factors resulting in mechanical failures of internal fixation of distal T-type and Y-type humeral fractures, we reviewed the clinical course and final results in 61 consecutive cases treated with AO-ASIF internal fixation devices. The patients were followed for at least 2 years (range, 2-11 years). Mechanical failure occurred in 18 cases (29.5%). In 12 patients this resulted from an unstable fixation. Severe osteoporosis was present in four patients. In two patients no specific causative factor could be detected. A second osteosynthesis was undertaken in five patients, and four additional patients were later operated on for nonunion. The functional outcome after these mechanical failures was, unexpectedly, poor in only 6 of the 18 patients. In spite of this comforting finding, the conclusion is that to minimize the failure rate in the management of these demanding fractures strict adherence to the correct technical fixation principles is mandatory, and when the bone is very osteoporotic a nonsurgical approach seems advisable.

Adolescent↗
PubMed1992

Postoperative complications of distal humeral fractures. 27/96 adults followed up for 6 (2-10) years.

Of 96 adult patients with a distal intercondylar, intraarticular fracture of the humerus treated operatively during a 10-year period, 27 patients suffered a local complication, while the total number of individual complications were 34. There were six postoperative infections, 12 neural injuries, and 16 fixation failures. Because of the complication, a reoperation was performed in 12 of the 27 patients. The final outcome was assessed at a reexamination after a mean follow-up period of 6 (2-10) years. Three patients had a permanent dysfunction of the ulnar nerve. In another 3 patients, failure of the fixation had resulted in an established nonunion of the distal humerus. It appeared that the possibilities of internal fixation in several cases had been overestimated.

Adolescent↗
PubMed1991

Occurrence and epidemiology of sports injuries in Finland.

The popularity of different sports activities has increased during the last three decades, a development that has been considered beneficial in many respects for society as well as the individual. One of the deleterious effects of this development, however, is an increased number of sports injuries. The exact incidence of sports injuries is difficult to calculate due to many potential biasing circumstances like data collection, definition of sports injuries and the lack of suitable control subjects. In a large study where the acute accidents in Finland were examined the incidence of sports injuries was 670/10,000 inhabitants in 1987. Seven per cent of the total number of injuries seen at a large casualty department were sports injuries. The main purpose of studying sports injuries is to identify the sportsmen at high risk of injury and the main risk factors. Only in this way can preventive measures be undertaken in an effort to make participation in sports safe, regardless of the level or type of sports practiced.

Adolescent↗
PubMed1990

Operations for the unstable cervical spine in rheumatoid arthritis. Sixteen cases of subaxial subluxation.

Sixteen patients with seropositive rheumatoid arthritis were operated on for subaxial subluxations. Four of the patients had slight, but progressive, tetraparesis, and 5 had severe or total tetraparesis; they were operated on 1-4 months after the first signs. Seven patients were treated for severe neck and shoulder pain. Nine patients had subluxation at the C3-4 level, the most common site, and 3 patients also had an atlantoaxial subluxation. Patients with cord compression were treated with posterior laminectomies and fusions that relieved the tetraparesis. Two patients died during the early postoperative period: 1 of a cardiac infarction and the other of pneumonia. During 4 (1.5-9) years' follow-up, 3 patients had new subluxations at other levels.

Adult↗
PubMed1989

DNA synthesis in prolyl 4-hydroxylase positive fibroblasts in situ in synovial tissue. An autoradiography-immunoperoxidase double labeling study.

DNA synthesis in prolyl 4-hydroxylase (PH; EC 1.14.11.2) positive fibroblasts in situ in synovial tissue was studied using an autoradiography-avidin-biotin-peroxidase complex (ABC) double labeling. Fibroblasts in monolayer culture and in situ in synovial tissue were PH positive, whereas freshly isolated peripheral blood lymphocytes, monocytes, dendritic cells and granulocytes were PH negative. In rheumatoid arthritis (RA) 37 +/- 3 (22-56)% of all DNA synthesizing cells in situ were PH containing fibroblasts, whereas all DNA synthesizing cells in patients with meniscus lesion were PH positive. In both conditions, more than half of the self-replicating fibroblasts were located in the lining cell layer. This is probably not an artifact caused by insufficient penetration of 3H-thymidine because most of the DNA synthesizing lymphocytes were deep down in the synovial stroma. In RA 51 +/- 8 (17-88) PH positive fibroblasts in the S phase of the cell cycle were observed/3 mm2 synovial tissue, whereas the corresponding figure in meniscus patients was only 1 +/- 1 (0-5) (p less than 0.01). This suggests that the local fibroblasts in RA are activated, probably as a result of various fibroblast growth factors produced locally as a result of the inflammatory synovitis. In RA however, less than 1% of all local fibroblasts were self-replicating in situ, whereas labeling indices over 5% were not uncommon in RA synovial fibroblast cultures. This finding suggests that uncontrolled fibroblast proliferation is regulated in vivo by negative feedback mechanisms.

Arthritis, Rheumatoid↗