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J Sandström

Publications and source records attributed to J Sandström.

29 records · Page 2Linked to original sources
PubMed1986

On the relation between drinking habits and alcohol problems.

In clinical practice it is important to consider the possibility of alcohol consumption as an etiologic or contributing factor for disease. Information concerning abuse might be obtained by e.g. interviews or indirectly by use of different abuse registers and/or laboratory screening tests. It was found in the present study that statements made by 95 patients with chronic low back pain on drinking habits correlated well with presence of alcohol related problems. Drinking statements thus appear to be useful, at least in well motivated individuals. In patients without alcohol problems the estimated mean daily ethanol consumption generally did not exceed 15 g. An ethanol intake exceeding 15 g per day more than one per week during the last six months was reported by about every third patient with former or present alcohol problems. Such a reported drinking pattern should make the doctor more vigilant about signs of alcohol abuse.

Adult↗
PubMed1986

Return to work after rehabilitation. The significance of the patient's own prediction.

A prospective study of patients with chronic low-back pain was made to determine the significance of the patient's own prediction of the outcome of a vocational rehabilitation program. Fifty-two patients were screened, and their work situation determined one and 4 years after the rehabilitation program was started. The patients predicted the outcome correctly in 69%, with a sensitivity of 68% and a specificity of 71%. A statistically significant correlation was found between the patient's prediction and the recommendations given by the rehabilitation unit.

Adult↗
PubMed1986

Clinical and social factors in rehabilitation of patients with chronic low back pain.

Physical signs, medical history and social factors were analyzed and evaluated in 52 patients (17 women and 35 men) with chronic low back pain, in order to determine if any factors were predictive for return to work after rehabilitation. Factors discriminating between the working and sick-disabled groups were: Sex (only men returned to full time work), Duration of sick-leave (the older half of the study population exhibited a negative correlation between time on sick-leave and frequency of return to work), Reported need for analgesics (the working group reported less need of analgesics), Pain in the cervical and dorsal areas of the spine as well as in the lumbar region (less frequent in the working group), The patients' attitude to his own ADL-capacity (those who returned to full-time work were more positive), After work fatigue (less frequent in the working group).

Absenteeism↗
PubMed1985

The bone mineral content of the lumbar spine in patients with chronic low-back pain.

The bone mineral content (BMC) of the third lumbar vertebra was determined in 43 patients with chronic low-back pain. No correlation was found to sex, height, pain experience, functional disability, or alcohol consumption. A positive correlation was found between the BMC and body weight and between the BMC and smoking in men (but not in women). A statistically significant negative correlation was found between the BMC and the overall duration of the back problem, ie, the longer duration the lower the BMC.

Adult↗
PubMed1984

HLA-B27 as a diagnostic screening tool in chronic low back pain.

Forty-five of 52 consecutive patients with chronic low back pain were screened for presence of HLA-B27 antigen one year after they were included in a rehabilitative program. Six (13.3%) were positive and, when re-examined radiographically, 2 had signs of ankylosing spondylitis. The proportion of antigen-positive individuals is similar to that found in a population study of healthy Swedish blood donors, and within the range of other populations of healthy controls. It is concluded that HLA-B27 is of limited diagnostic value as a screening test for ankylosing spondylitis in a patient group with chronic low back pain.

Adult↗
PubMed1984

The role of alcohol abuse in working disability in patients with low back pain.

The prevalence of alcohol problems was investigated in 50 patients with chronic low back pain, and compared to an age, sex, civil status, and income matched control group. Alcohol abuse was significantly more frequent among the male low back patients. Within the patient group the use of analgesics and sedatives was not related to the degree of alcohol consumption. Alcohol problems were not found to influence the rehabilitation process negatively, probably because the rehabilitation programme was not directed to the back only. Such problems therefore should not discriminate against inclusion in a rehabilitation programme.

Adult↗
PubMedDate not supplied

Expression of the proteolytic factors, tPA and uPA, PAI-1 and VEGF during malignant glioma progression.

Various proteases and their inhibitors have been shown to be important in tumor invasion. Angiogenesis is further a prerequisite for the growth and progression of solid tumors. Since these systems are functionally linked, in situ hybridization and in situ zymography were used to investigate the spatial and temporal expression of factors representative of the plasmin/plasminogen system and of an angiogenic factor in the BT4C glioma model. This tumor is invasive with a high grade of neovascularization. Tissue-type plasminogen activator urokinase-type plasminogen activator and plasminogen activator inhibitor-1 mRNA were expressed in glioma cells during the entire tumor growth. Early in the tumor development the expression was found throughout the small tumor (approximately 10 mm3) while later in the time course the expression was found predominantly in the invasive tumor border of the tumor. The in situ zymography demonstrated that the plasminogen activators were translated into functional proteins. Vascular endothelial growth factor mRNA was expressed following a similar spatial and temporal pattern with an early expression in the entire small tumor while later, in larger tumors, it was exclusively expressed in the invasive tumor edge. In normal brain, the ventricular ependyma, meninges, as well as scattered neurons expressed tissue-type plasminogen activator mRNA. Vascular endothelial growth factor mRNA was observed in the choroid plexus, and in scattered cells in normal brain tissue. Our finding may suggest a functional co-operation of tissue-type plasminogen activator, urokinase-type plasminogen activator, plasminogen activator inhibitor-1 and vascular endothelial growth factor during glioma progression. This model could be of value when evaluating different treatment modalities aimed at blocking the migrating capacity and growth of glial tumors.

Animals↗