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J Sane

Publications and source records attributed to J Sane.

At least 19 recordsLinked to original sources
PubMed2000

Solitary fibrous tumour of the oral cavity: clinicopathological and immunohistochemical characterization of three cases.

Solitary fibrous tumour (SFT) is an uncommon mesenchymal neoplasm rarely located in the oral cavity. To characterize further oral SFT, we describe three new cases. Each tumour originated in the buccal mucosa of a middle-aged/elderly patient. Histological examination showed well-circumscribed tumours with densely cellular areas alternating with hypocellular areas in a variedly collagenous, vascular stroma. Mast cells were abundant. The spindle-shaped, neoplastic cells immunostained strongly for CD34 antigen and vimentin and weakly for bcl-2, but not for epithelial cell markers, alpha-smooth muscle actin, or neurofilament or S-100 proteins. Compatible with the virtual absence of mitoses and of marked nuclear atypia, the overall frequency of proliferating cells expressing Ki-67 was low. The expression of CD34 was useful in the differential diagnosis. The consistent location in the cheek and expansion of one tumour after local trauma does not preclude a traumatic element in the development of oral SFT.

Aged↗
PubMed1997

Traumatic injuries among university students in Finland.

A questionnaire dealing with the incidence of traumatic injuries was sent to 1,000 randomly selected 3rd-year university students in Finland; 617 students responded adequately. Of those, 177 (28.7%) reported a combined total of 281 accidents and 323 separate injuries requiring medical or dental treatment during the preceding 3 years. The accidents resulted in 1,061 days of official sick leave, and one third of the accidents caused permanent sequelae to the affected students. Almost half of all accidents had been sustained during sports activities and 14% in traffic. Only 0.5% of the accidents were classified as having occurred in the university environment or during activities directly related to studies. Alcohol was involved in 10.1% of the accidents; 45% of the injuries affected the lower extremities, and 22% the upper extremities. Most of the injuries were related to the students' active lifestyles and keen interest in sports.

Accidents, Traffic↗
PubMed1993

Peripheral nerves and mast cells in normal buccal mucosa.

The topographical distribution and relation to mast cells of PGP 9.5 (protein gene product 9.5, a major cytoplasmic neuron-specific protein with ubiquitin C-terminal hydrolase activity) and neurofilament (intermediate neuron-specific cytoskeletal filaments) in normal human buccal mucosa was studied in five healthy volunteers. Morphometric analysis disclosed the densest innervation to be in the middle layers of the lamina propria, with a mean number of 5.9-6.1 PGP 9.5 and/or neurofilament-immunoreactive nerve fiber profiles per one mm2. In contrast, the mean mast cell number decreased from 110/mm2 to 46/mm2 from superficial to deep lamina propria, being 69-72/mm2 in the most densely innervated middle layers. Only 16-17% of all fiber profiles contained substance P and 51-54% calcitonin gene-related peptide (CGRP). Finally, analysis of the spatial relationship between nerve fiber profiles and mast cells in a double staining procedure disclosed no preferential neuron-effector associations. All these findings suggest that such a relationship does not exist between peripheral nerves and mast cells in normal buccal mucosa.

Adolescent↗
PubMed1990

A six-year follow-up study of sports-related dental injuries in children and adolescents.

The records were analyzed of 106 patients with sports-related dental traumas treated in 1983 at the public oral surgery unit in Helsinki, Finland; 51 were examined six years after injury. The mean age was 11.8 years (range 7-24 years). The woman/man ratio was 1:3. In 39% of cases, the injuries had arisen from ice hockey or skating; 30% happened during school hours; 80% were uncomplicated crown fractures, concussions or subluxations. During the six-year follow-up, of 80 teeth in 51 patients, root resorption was found in 6 teeth (7.5%), periapical lesions were noted in 2 teeth (2.5%), and obliteration of the pulp was seen in 4 teeth (5%). Three teeth (3.7%) had suffered loss of vitality. The pulp had been extirpated in 13 of the traumatized teeth (16%). In all, 13.7% of the patients were found to have complications six years later. The results showed that long follow-up periods are needed after dental injury.

Adolescent↗
PubMed1989

Florid cemento-osseous dysplasia (gigantiform cementoma) in a Caucasian woman.

The present study reports a case of an uncomplicated florid cemento-osseous dysplasia in a 39-year-old Caucasian woman. The extensive dysplastic lesions affected all jaw quadrants and both radio-opaque and lytic lesions were demonstrated radiographically. Histopathological studies revealed calcified, partly acellular cementum-like tissue. All clinical, radiographic, biochemical and histological features were suggestive of the diagnosis of florid cemento-osseous dysplasia.

Adult↗
PubMed1988

Topical treatment of oral leukoplakia with bleomycin.

Ten patients with oral leukoplakia were treated topically with bleomycin. We found the method convenient but only successful where sufficient attention was paid to the activity of the bleomycin-dimethylsulphoxide solution. The initial epithelial dysplasia disappeared completely in five of the 10 patients, while in the remainder the dysplastic grade remained the same. Following treatment the thickness of the keratotic layer increased in four patients, became thinner in five and remained unchanged in one. Although clinically the results of treatment only appear some 3 months after bleomycin application, once the lesions are cured their recurrence seems to be slower than after surgery. Nevertheless we strongly emphasise that 3-monthly follow-ups are mandatory for patients with oral leukoplakias whether or not they have been treated successfully.

Administration, Topical↗
PubMed1988

Sports-related maxillofacial fractures in a hospital material.

Sports-related maxillofacial fractures were analysed in 80 patients, accounting for 5.6% of all patients with facial bone fractures, treated during the 5-year period 1981-1985. 55% of the patients had 1 or more mandibular fractures and 45% had midface fractures. 6% of the patients had multiple injuries. The most common causes of injury were collision and fall. Soccer and ice hockey turned out to be the most hazardous sports, although sports-related maxillofacial fractures were less severe than those related to other causes. The need for oral and facial protection among athletes involved in contact sports is discussed.

Adolescent↗
PubMed1988

Bone resection in patients with mandibular sarcoma.

Thirty-nine cases of mandibular sarcoma were reported to the Finnish Cancer Registry during the period 1953-1985. In 11 of these (nine osteosarcomas, one chondrosarcoma, one leiomyosarcoma), the pre- and postoperative radiographs were still available, and they were analyzed in order to evaluate the radicality of the primary surgical procedure in relation to recurrences during the follow-up. On the basis of several radiological details, the resection was considered inadequate in seven cases. One operation was probably inadequate because of rather scanty margins. In only three cases had an adequate primary resection with proper safety margins been performed. All of the seven patients with inadequate primary surgery had recurrence and five of them died of local disease or metastases, whereas only one of the three patients with adequate resection had recurrence in adjacent soft tissues. It is concluded, that radiological findings of mandibular sarcoma that often are missed include widening of the mandibular canal and disappearance of the lamina dura. Proper preoperative radiological examination resulting in more radical primary surgery would certainly decrease the recurrence and mortality rates in patients with mandibular sarcoma.

Adult↗
PubMed1988

Maxillofacial and dental ice hockey injuries.

Maxillofacial and dental ice hockey injuries in Finland were studied during 1979 to 1985. A total of 6,885 accidents occurred to registered players between 1979 and 1982, and 791 (11.5%) of them affected the maxillofacial and dental regions. There were 1,401 separate injuries during the same period, 1,184 of which (84.5%) affected the teeth. The most common cause of accidents (in 54.1% of cases) was a blow received from a stick. Maxillofacial and dental injuries accounted for 38.0% of the total cost of all ice hockey injuries. The mean cost of maxillofacial and dental injuries was over 3 times as high as that for ice hockey injuries as a whole. The use of a mandatory full-cage face mask greatly reduced the number of maxillofacial and dental injuries and hence the cost of treatment.

Adolescent↗
PubMed1987

Maxillofacial and dental soccer injuries in Finland.

Between 1979 and 1982 there were 8640 accidents to registered soccer players in Finland. Of these, 552 (6.4%) affected the maxillofacial and dental regions. Medical records were located relating to 537 of these cases (97%). There were a total of 843 injuries, of which 681 (80.8%) affected the teeth or alveolar processes, and 95 (11.2%) were fractures of the lower or middle third of the facial skeleton. The most common cause of the accidents (in 86.4% of cases) was contact with another player. The mean cost of maxillofacial and dental injuries was over twice as high as the mean cost relating to all soccer injuries. The need for the use of mouthguards by soccer players to protect against such injuries is discussed.

Adolescent↗
PubMed1987

Ultrastructure of oral leukoplakia and lichen planus. I. Basal region and inflammatory cells.

Nine cases of homogenous leukoplakia and 21 cases of lichen planus (11 reticular and 10 erosive) were studied under the electron microscope. The changes found in leukoplakia were limited to occasional breaks in the basal lamina and modest changes in the cytoplasm of the basal cells. The basal lamina in lichen planus was found to exhibit 3 distinctly different pictures reflecting the clinical types of lichen planus. The structural abnormalities in the basal cells increased with increasing severity of the lesions. The inflammatory infiltrate in lichen planus was found to contain mainly small-to-medium-sized lymphocytes but plasma-cells with widely dilated rough endoplasmic reticulum containing a granular substance were frequently seen. Similar changes are seen in other disorders and, therefore, specific diagnostic criteria cannot be established on the basis of the present material.

Basement Membrane↗
PubMed1987

T lymphocyte activation state in the minor salivary glands of patients with Sjögren's syndrome.

Local lymphoplasmacytoid infiltration of the diseased exocrine glands is a cardinal sign of Sjögren's syndrome (SS). The state of T lymphocyte activation present in these local infiltrations was studied by three different techniques: determination of interleukin 2 (IL2) receptor (Tac) on cell surface membrane; autoradiography combined with immunoperoxidase staining of T cell epitopes; and electron microscopic analysis of the lymphoblast subclasses. Although 64 (SEM 4)% of the local inflammatory cells expressed Ia antigen, only 4 (SEM 1)% of them displayed the T cell activation antigen Tac. Autoradiography-immunoperoxidase double labelling showed that less than 1% of all T cells in situ were [3H]thymidine incorporating blasts. This finding suggests that although T lymphocyte is the dominant cell in situ, only a few of these cells have passed the G0/G1 interphase, and even fewer have been pushed to the S phase of the cell cycle by IL2. Transmission electron microscopy showed that few T blasts were present, even though there were many plasma cells. This result further confirms the impression that only a minor T cell subpopulation in situ is blast transformed despite the fact that many of the local T lymphocytes in the diseased salivary glands in SS are Ia positive.

Adult↗
PubMed1986

Osteosarcoma of the mandible: analysis of nine cases.

A total of 16 cases of mandibular osteosarcoma were diagnosed histologically in Finland and reported to the Finnish Cancer Registry between 1953 and 1983. Review of the histologic slides confirmed the diagnosis in only nine cases. The overall five-year survival rate was 44%. Three patients who were free of clinical disease at the end of the follow-up period (mean, 9.9 years) either had tumors of low-grade malignancy (two cases) or had undergone prompt radical surgery (one case). The importance of radiography in the diagnosis of mandibular osteosarcoma is stressed, because the widening of the periodontal membrane spaces, the sunray effect, and the widening of the mandibular canal are almost pathognomonic for osteosarcoma.

Adult↗
PubMed1984

Analgesic efficacy after single and repeated doses of codeine and acetaminophen.

A double-blind randomized analgesic trial was carried out in patients suffering from pain after removal of a third molar tooth. In a two-dose regimen, 108 patients received either 60 mg codeine, 500 mg acetaminophen, or 1000 mg acetaminophen. On the day of surgery, the patients assessed their pain intensity hourly on a visual analog scale. The evaluation was carried out during the 10-hour period after first medication. The best pain reducing effects were achieved with 1000 mg acetaminophen. Both the category and position of each tooth were examined in relation to pain intensity; however, the statistical analysis did not reveal any significant correlation. In all treatment groups, the efficacy of the second dose was superior to that of the first, and the most pronounced difference was obtained in patients taking codeine, who increased their pain reduction from 20 to 60 per cent. Clinical comparisons including codeine may therefore be better carried out in a repeated-dose regimen.

Acetaminophen↗