PubMed Health⌕ Search

Biomedical subjects

J Santini

Publications and source records attributed to J Santini.

81 records · Page 5Linked to original sources
PubMed1986

Induction chemotherapy with cis-platinum and 5-fluorouracil for squamous cell carcinoma of the head and neck.

One hundred and eight patients with squamous cell carcinoma of the upper aerodigestive tract (UADT) (T3, T4, NO-N3; 17% stage II, 54% stage III, 27% stage IV) were given three courses of chemotherapy before any local treatment. The regimen consisted of cis-platinum 100 mg m-2 on day 1 and 5-fluorouracil 1000 mg m-2 on days 2-6; drugs were administered by continuous infusion. The toxicity of this protocol was acceptable, as 82% of the patients were able to receive the initially scheduled drug dose. The overall response rate of 86.5% included a 35% rate of complete lesion regression. The effect of this regimen on primary tumours was especially remarkable--87.5% responses, including 47.5% complete responses. Results for lymph node metastases were not as good--66% responses, including 33% complete responses. The best results were obtained for tumours of the oropharynx and hypopharynx; oral cavity lesions were the most refractory. For those patients who were subsequently operated on, histological examination of the surgical specimen either confirmed sterilization or demonstrated the persistence of small disease foci. After local treatment, which consisted of radiotherapy alone for 69% of patients, the lesion control rate was 80%. At 18 months follow-up, the survival rate for patients who achieved a complete response with chemotherapy was significantly better than that for patients with a response of less than 50%.

Adult↗
PubMed1986

[Poncet-Spiegler cylindroma. Apropos of a recent case].

The authors describe a new case of multiple cutaneous cylindromas (Poncet-Spiegler cylindroma), and discuss the clinical and histopathological characteristics of this rare affection. Treatment is exclusively surgical, with plastic surgery being required for advanced cases. In the case presented, a free flap from the forearm was used to cover the area of extensive loss of cutaneous matter in the parotid region.

Carcinoma, Adenoid Cystic↗
PubMed1985

[Intra-arterial chemotherapy of ORL tumors. 10 years' experience in the Antoine-Lacassagne Center].

One hundred and two patients with malpighian epithelioma of ORL origin were treated with intra-arterial chemotherapy (IAC) as initial therapy, followed by either surgery, radiotherapy or a combination of the two. Regression in tumor size of more than 50% was noted in 46% of cases, the introduction of cisplatin into the multiple system chemotherapy providing a response in 71% of the 42 patients treated in this way. A response to induction IAC is a factor of good prognosis as shown by the improvement in level of local and regional extensions and the probability rate of survival in responders. Technical and methodologic progress has made IAC a simple and effective procedure, and its place in the treatment of epitheliomas of head and neck should be established more precisely.

Adult↗
PubMed1984

[Pectoralis major musculocutaneous flap after oncologic excision of the buccal cavity and oropharynx].

A musculocutaneous flap from pectoralis major was used for reconstruction after widespread excision for cancer of the oral cavity and oropharynx in 54 cases, the method of choice being transposition as islets. Necrosis in 6 cases (11%), was partial in 5 patients and was limited to the skin layer only. The advantages of the musculocutaneous flap from pectoralis major when compared with other reconstructive procedures, particularly deltopectoral and temporofrontal flaps, are discussed.

Female↗
PubMedDate not supplied

Response to chemotherapy as justification for modification of the therapeutic strategy for pharyngolaryngeal carcinomas.

From September 1983 to September 1987, 238 patients with squamous cell carcinoma of the upper aerodigestive tract were given 3 cycles of chemotherapy [cisplatinum (cis-DDP), 100 mg/m2 on day 1; 5-fluorouracil (5-FU), 1,000 mg/m2 on days 2-6] before any local treatment. Eighty-one of these patients had pharyngolaryngeal cancer. Of the 45 of 50 laryngeal cancers and 26 of 31 hypopharyngeal cancers suitable for evaluation, complete responses (CR) were obtained in 51.1% and 53.8%, respectively. These response rates led to changes in the postchemotherapy protocols. For CRs, multilating surgical protocols were replaced by definitive radiotherapy: one local recurrence has been observed among the 9 laryngeal cancers, and 3 of 10 hypopharyngeal cancer patients, who had an initial indication of total laryngectomy or total pharyngolaryngectomy replaced by radiotherapy. In the group of CR, survival rates at 2 years were 93% and 69%, respectively, for the larynx and hypopharynx vs 65.6% and 40% for non-CR patients. The possibility of conservative treatment sparing vocal function with a high degree of reliability would in itself appear to be justification for induction chemotherapy in pharyngolaryngeal cancers, even though its long-term effects remain controversial.

Adult↗
PubMedDate not supplied

Characterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas.

Epidermal growth factor (EGF) stimulates the growth of several types of epithelial tissues and possesses a strong mitogenic activity that is mediated through its cell surface receptor (EGFR). The aim of this study was to characterize EGFR and measure its levels in head and neck tumors biopsies (70 patients); use of a simplified competition technique with a radiolabeled ligand allowed evaluation of functional EGFR. Five samples (4 tumors and 1 control) were used to characterize EGF binding. Graphic representation identified a single family of binding sites. Kd values revealed high affinity for EGF binding: mean Kd, 0.156 +/- 0.108 nM (0.095-0.347 nM). EGF-binding characteristics (Kd) were similar in nontumoral tissue samples (controls) and in tumor material. In 59 of 60 cases, EGFR levels were higher in the tumor than in the corresponding controls. A significant correlation was found between EGFR levels and tumor size and stage. Controls exhibited a trend toward higher EGFR levels in elevated sizes and stages. According to a cutoff EGFR value of 100 fmol/mg protein, which separated all controls from tumors, EGFR-positive tumors (greater than 100 fmol/mg protein) had a greater probability of complete response to chemotherapy than EGFR-negative tumors; other tumor characteristics, such as the degree of tumoral differentiation, tumor size, or stage, were unable to operate such a discrimination in the response to chemotherapy. EGFR may thus be an interesting biological marker for head and neck cancer.

Adult↗
PubMedDate not supplied

Sedimentation rate and serum thymidine kinase activity: prognostic factors in squamous cell head and neck cancer.

Identification of prognostic factors in squamous cell head and neck cancers involves analysis of highly diverse clinical and biological parameters. This study analyzed the prognostic value of clinical variables (age, sex, tumor site, stage) and biologic parameters (squamous cell carcinoma antigen [SCC], serum thymidine kinase activity [TK], fibrin, sedimentation rate [SR]) at the time of diagnosis of squamous cell carcinoma of the head and neck (oral cavity, oropharynx, hypopharynx) in 189 patients. Among the clinical variables investigated, UICC stage III-IV disease (p < .0002), a hypopharyngeal site (p < .02), and age over 60 years (p < .01) were all associated with a poor prognosis. Similarly, analysis of biological blood variables allowed definition of cut-off values above which the prognosis was poor: SCC 2.5 ng/mL (p < .01), fibrin 3.5 g/L (p < .01), TK 7 IU/L (p < .0005), and SR 15 mm per first hour (p < .0000). Cox regression analysis of overall survival identified the UICC stage (p < .000), the SR (p < .001), and serum TK (p < .02) as the main independent prognostic factors. A separate study on a small number of head and neck cancer patients revealed higher TK levels in malignant squamous cell carcinoma tissue than in adjacent healthy tissue.

Adult↗