[The impacted third molar: extract or save?].
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Humans↗
Biomedical subjects
J Saucier
Publications and source records attributed to J Saucier.
Effect of glucocorticoid administration in vivo on insulin binding in rat testis.
We have studied the effects of adrenalectomy and glucocorticoid injections on insulin binding in membranes from rat testis and liver. Glucocorticoids were administered for 7 days to adrenalectomized rats at daily doses of 30 or 300 micrograms for dexamethasone and 100 or 1000 micrograms for prednisolone. Glucocorticoids, at the selected doses, were associated with 5- to 10-fold increases in basal insulin levels with no significant changes in glucose concentrations. As previously shown by other studies, down-regulation of insulin receptors was observed in liver membrane particularly at the higher dose of steroids. Such an effect was not found in the testis. By contrast, the number of high-affinity sites in the testis was slightly increased with the higher doses of dexamethasone and prednisolone. However, percent 125I-labelled insulin binding was not significantly changed after corticotherapy. These results are in accord with our previous studies and suggest that the testicular receptor for insulin is not affected by mild to moderate changes of insulin concentrations, but that it can be modulated by glucocorticoids through other mechanisms.
Animals↗
Changes in insulin binding in rat testis following testosterone and gonadotrophins administration.
Rat testis membranes possess insulin receptor whose autoregulation is different from conventional insulin target organs. In order to verify the importance of the functional activity of the Leydig cells, different approaches were selected to provoke a resting state of the cells and to measure insulin binding. Testosterone cypionate and LH-RH agonist administration, as well as hypophysectomy, led to a 50% decrease of insulin binding in testis while no effect or a slight increase was observed in hepatic membranes following hypophysectomy. HCG treatments restored insulin binding to its control levels in hypophysectomized animals. These modifications occurred without significant changes in insulin and glucose concentrations. It is concluded that pituitary LH is a key factor in controlling Leydig cell activity as well as its insulin receptor content.
Animals↗
An analysis of cerebral bood flow systemic base deficit accumulation and mean arterial pressure as a function of internal cardiac massage rates.
The effect of varying rate of internal cardiac massage on the cerebral blood flow equivalent (CBF/CMRO2 = (Formula: see text), where CBF = cerebral arteriovenous oxygen difference, CMRO2 = Cerebral metabolic oxygen consumption, and (Formula: see text), = cerebral; arteriovenous oxygen content difference) was investigated in the dog. Also, systemic base balance and mean arterial pressure were analyzed as functions of rate. Nine dogs 14-27 kg in weight were subjected to rates of 14-200 compressions per minute. For rates between 14 and 200 per minute, there was no significant rate-related effect on the parameters monitored.
Acid-Base Imbalance↗