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Biomedical subjects

J Saurel

Publications and source records attributed to J Saurel.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Swyer syndrome. Apropos of a new case of pure gonadal dysgenesis with Karyotype 46 XY].

The authors describe a case they have personally seen of pure gonadal dysgenesis with caryotype 46 XY (Swyers' syndrome) in which they found absence of HY antigen. They analysed the descriptions in the literature about this syndrome and show how this antigen is responsible for testicular differentiation. They show the place this syndrome has in the group of syndromes of bands and once again draw attention that there is a great risk of gonadoblastoma development when the Y chromosome is present and especially when the HY antigen is present. This means that these dysgenetic gonads should be removed surgically.

Adolescent↗
PubMed1982

[Cytological complications of IUDs ].

The cytological modifications due to IUDs are incompletely or inaccurately known to clinicians and cytologists. IUDs of all types bring about a modification of the maturation index, and particularly of the estrogenic index which, throughout the cycle, appears to be lower than that of a control group. The presence of a sub-normal inflammatory contest in smears of IUD users is no proof of an increased incidence of microbic infections. Presently there is no sign of any carcinogenic role played by IUDs. The papillary metaplasia induced by IUDs appeared more frequently than squamous endometrial metaplasia.

Adult↗
PubMed1981

[Behavior of an intra-uterine device in the abdomen of animals (author's transl)].

The authors have carried out an experimental study on the reaction of an animal's organism to the presence of an open copper intra-uterine device when placed in the abdomen. The study was carried out on two groups each of 10 rabbits and two bitches. The intra-uterine device was placed in the pouch of Douglas by laparotomy, directly in one group and after contamination with genital secretions in the other. The state of the animals was checked six weeks after the initial laparotomy. Trauma caused by the operation was minimal because there were no adhesions found on the parietal peritoneum. On the other hand in experimental conditions that are very similar to those found when an intra-uterine device goes through the uterus in a human subject and involves contamination with genital secretions, in 50 per cent of cases the intra-uterine device migrated within the abdominal cavity. It was picked up by the omentum and this underwent such a strong fibrous reaction that it brought about multiple intestinal adhesions. Though the authors admit that experimental results in animals cannot be extrapolated to women, they believe that these results should be taken into consideration and that it would be imprudent to leave an intra-uterine device in the abdomen in a woman when there is proof that it has migrated, because there would then be a major risk of intestinal obstruction due to an adhesion that as formed a band.

Animals↗
PubMed1979

[Demonstration of the myotoxic effect of theophylline on the isolated kidney glomerulus of the rat].

After confirmation of the intense and very fast myorelaxant effect of theophylline on isolated glomeruli, xanthic reagent myotoxic effects are shown during more or less long contacts with these glomerular suspensions. We studied isolated glomeruli diameter evolution according to reagent dose (0,25 to 10 mg/ml) and its contact length (1, 5, 10 minutes). If the diameter remains practically constant during all the period for the lowest doses, it begins to decrease after the 5th minute for higher (1 and 2,5 mg/ml) and cracks up in the first minutes for the biggest ones (5 and 10 mg/ml). Pharmacologic and toxic actions are discussed ; hypothesis of a toxic effect at smooth muscular cells level is proposed.

Animals↗
PubMed1979

[Leydig cell tumor of the ovary (biologic (in vivo and in vitro) and ultrastructural study) (author's transl)].

The authors present the case of a young hirsute woman of 28 years old. Urinary 17 KS were very increased without DHA, but with androsterone, etiocholanolone and 11 oxy 17 Ketosteroids. Androstenedione and testosterone plasmatic levels were very high and per operative selective ovarian vein catheterization showed a direct production of these potent androgens. In vitro study of the tumor allowed to obtain same results. Light and electron microscopic study showed a Leydig cell tumor of left ovary.

17-Ketosteroids↗
PubMed1978

The myorelaxant effect of theophylline on smooth muscle cells of the afferent arterioles and glomerular tuft.

Theophylline, infused i.v. into rats increased the diameter of the glomerular afferent arterioles by 35.78%; when added to a suspension of isolated glomeruli, it increased the diameter of the capillary tuft within the glomerulus by 25-30%. These variations in diameter can be explained by the myorelaxant effect of theophylline on the smooth contractile fibers present in the arteriolar cells and in certain glomerular cells, such as the mesangial cells. These observations explain, in part, the marked changes in glomerular hemodynamics caused by the injection of theophylline.

Animals↗