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Biomedical subjects

J Scammell

Publications and source records attributed to J Scammell.

3 recordsLinked to original sources
PubMed1999

Back to basics: exploring the conceptual basis of nursing.

It has long been recognized that nursing is essentially a practice-based discipline, underpinned by fundamental concepts which inform practice. The purpose of this paper is two-fold: first, to discuss the need for an exploration of these concepts of nursing as a foundation to pre-registration nursing programmes. Second, by utilizing a continuous quality improvement perspective, an evaluation of teachers' experiences with a cohort of adult and child health branch students is considered. It is concluded that a significant proportion of students found that a raised conceptual awareness served to promote theory-practice links.

Adult↗
PubMed1999

Species-specific, postentry barriers to primate immunodeficiency virus infection.

By using replication-defective vectors derived from human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV(mac)), and murine leukemia virus (MuLV), all of which were pseudotyped with the vesicular stomatitis virus (VSV) G glycoprotein, the efficiency of postentry, early infection events was examined in target cells of several mammalian species. Titers of HIV-1 vectors were significantly lower than those of SIV(mac) and MuLV vectors in most cell lines and primary cells from Old World monkeys. By contrast, most New World monkey cells exhibited much lower titers for the SIV(mac) vector compared with those of the HIV-1 vector. Prosimian cells were resistant to both HIV-1 and SIV(mac) vectors, although the MuLV vector was able to infect these cells. Cells from other mammalian species were roughly equivalent in susceptibility to the three vectors, with the exception of rabbit cells, which were specifically resistant to the HIV-1 vector. The level of HIV-1 vector expression was very low in transduced cells of rodent, rabbit, cow, and pig origin. Early postentry restriction of primate immunodeficiency virus infection exhibits patterns largely coincident with species borders and applies to diverse cell types within an individual host, suggesting the involvement of species-specific, widely expressed cellular factors.

Animals↗