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Biomedical subjects

J Schaanning

Publications and source records attributed to J Schaanning.

15 recordsLinked to original sources
PubMed1991

The effect of hyperventilation in cluster headache patients.

The effect of voluntary hyperventilation was assessed in 22 cluster headache patients (8 in a cluster period and 14 in a remission) and 19 healthy individuals. Using an ear oximeter and a capnograph with a nasal probe, the oxygen saturation (SaO2) and the end-tidal CO2 were monitored continuously. During the hyperventilation per se, cluster headache patients and controls showed absolute values of end-tidal CO2 and of SaO2 of the same order of magnitude. In the posthyperventilation phase, however, the average of the lowest SaO2 levels was lower in controls than in cluster headache patients. In the posthyperventilation phase, headache patients outside the cluster period showed a trend more similar to that of the controls with respect to SaO2 than did those inside the cluster period. The observed discrepancy might, if reproducible, be a consequence of an altered chemoreceptor sensitivity in cluster headache patients during the bout.

Adult↗
PubMed1991

Comparison between Bricanyl Turbuhaler and Ventolin metered dose inhaler in the treatment of exercise-induced asthma in adults.

The aim of the present study was to compare the effect of Bricanyl Turbuhaler (0.5 mg x 1 terbutaline) with the effect of albuterol metered dose inhaler (0.1 mg x 2 albuterol) in patients with reproducible bronchoconstriction. The study was performed as a double-blind placebo-controlled trial in sixteen asthmatic adults. Bronchoconstriction was induced by steady state running on a treadmill. Both 0.5 mg terbutaline and 0.2 mg albuterol have good bronchodilating effects in patients with exercise-induced asthma. There was, however, a faster onset of action after albuterol. The clinical value of this observed difference is uncertain.

Administration, Intranasal↗
PubMed1991

Bambuterol: a new long acting bronchodilating prodrug.

Bambuterol, a carbamate prodrug of terbutaline as a 5, 10, or 20-mg tablet, was given once every evening to patients with asthma in a randomized double-blind crossover study. Twenty milligrams improved pulmonary functions over 24 hours; 5 and 10 mg did not. Few side effects were observed.

Administration, Oral↗
PubMed1990

Cluster headache: the effect of low oxygen saturation.

The present study concerns the possible relationship between hypoxia and the generation of cluster headache attacks. Fifteen controls and 25 cluster headache patients were studied. The patients were allocated into two groups according to cluster headache stage, i.e. cluster or remission period. During the tests, all the subjects were asked to inhale 12% oxygen (88% N2) for 30 min, and the decreasing oxygen saturation (SaO2%) was monitored. Patients in the remission period showed nearly the same decrement of SaO2% as controls. At the end of the test, patients in the bout showed significantly less reduction of SaO2% than the controls. In 5 patients, the test was carried out both in and outside the cluster periods. The tendency to less decrement in oxygen saturation in the cluster phase was as marked with this comparison, but the difference between the groups was not significant, probably partly due to the low number of tests carried out. Only one patient got a typical attack. It seems that hypoxia of this magnitude per se is not the cause of attacks. The different pattern with respect to SaO2% following 12% O2 inhalation in cluster headache may be due to an abnormality in central regulation and/or chemoreceptor sensitivity.

Adult↗
PubMed1988

A comparative study of the effect of three doses of nedocromil sodium and placebo given by pressurized aerosol to asthmatics with exercise-induced bronchoconstriction.

The effect of placebo and 1 mg, 4 mg, or 8 mg nedocromil sodium, administered 60 minutes prior to treadmill challenge, was determined in a double-blind study of 12 adult asthmatics with reproducible exercise-induced bronchoconstriction. All nedocromil sodium treatments gave significantly smaller falls in PEFR than placebo. Four and 8 mg gave significantly greater protection than 1 mg.

Adult↗
PubMed1986

Effects of cold air inhalation combined with prolonged submaximal exercise on airway function in healthy young males.

In a group of 30 well trained young males (age 10-36 years) we did not find clear changes in spirometric values during and after 20 minutes submaximal exercise and cold air inhalation down to -16 degrees C. Smaller cold-related changes in lung volumes, breathing pattern and specific airway conductance was found, however. The youngest age group was not particularly cold-sensitive concerning airway function. Two subjects showed considerable stronger airway reaction than the rest of the group.

Adolescent↗
PubMed1978

Respiratory cycle time duration during exercise in patients with chronic obstructive lung disease.

Respiratory cycle time components during rest and graded exercise were measured in 18 patients with chronic obstructive lung disease, and compared with controls matched for sex and age. For a given exercise level (50 W) increased minute ventilation was present in the patients. This was due to shorter cycle time. Both inspiratory and expiratory time shortened to the same degree rendering the ratio inspiratory time/total respiratory cycle time similar in the two groups. At maximal exercise total respiratory cycle time and inspiratory time was shorter in the patients than in the control group, but the ratio between them was still similar. However, for a given total cycle time during maximal exercise inspiratory time was shorter. Inspiratory time and the ratio inspiratory time/total cycle time as measured during 50 W exercise, were positively correlated with the patient's exercise capacity, but not of sufficient accuracy for useful prediction of the latter. The difference in concomitant variation of tidal volume and inspiratory time during exercise ventilation between the patients and the control subjects seemed satisfactorily explained by the different lung volumes at which the two groups were breathing.

Adult↗
PubMed1976

Effect of atenolol on ventilatory and cardiac function in asthma.

The effects on ventilatory and cardiac function of atenolol, a new cardioselective beta-adrenoceptor blocking agent, were compared with those of practolol in a double-blind trial in 12 patients with asthma. Both drugs impaired ventilatory function--atenolol insignificantly and practolol significantly. Atenolol was if anything more cardioselective than practolol. Neither drug interfered significantly with the bronchodilator response to inhaled isoprenaline. Atenolol is suitable for use in patients for whom practolol would formerly have been chosen because of its cardioselectivity.

Adrenergic beta-Antagonists↗
PubMed1976

Beta1-blocker (practolol) and exercise in patients with chronic obstructive lung disease.

Ventilatory and circulatory data from 20 patients suffering from chronic obstructive lung disease have been obtained before, during and after exercise at 600 kpm/min for 5 min on a bicycle ergometer. The patients had been given intravenously practolol, 15 mg, or saline alternatively, using a double-blind cross-over technique. A slight postexercise reduction of FEV1 (8%) was noted after practolol medication as compared to placebo, with an accompanying decrease in PaCO2; PaO2 did not differ substantially. No wheezing or inappropriate dyspnea attributable to the medication was noted in any of the patients. The well known beta1-blocking effects on the circulation were confirmed, with maintained Q and reduced HR, together with a lowered systemic BP during and after exercise. There was a significant positive relationship between the postexercise reduction of FEV1 and the concomitant fall in HR. It is concluded that practolol in doses with near maximal circulatory effects had a slight, but clinically insignificant effect on the ventilatory parameters.

Adult↗
PubMed1976

Influence of posture on pulmonary gas exchange and heart rate in chronic obstructive lung disease.

Sixteen subjects with chronic obstructive lung disease were studied in supine and sitting position. VT, VE, VD and VD/VT were definitely higher in the sitting position (p less than 0.001). PaCO2 was slightly lower in the sitting position, whereas Pa¿O2 was the same in both positions. P(A-a)O2 was essentially the same in both positions, but the estimated QS/QT was definitely lower in the sitting position. In patients with low FEV1.0 the heart rate showed a tendency towards higher values in the sitting position.

Adult↗
PubMed1976

Ventilatory and heart rate adjustments during submaximal and maximal exercise in patients with chronic obstructive lung disease.

Thirty-four patients with chronic obstructive lung disease were exercised stepwise up to maximal work load. V02 at maximal work load showed a slightly significant correlation to FEV1, while a closer association with VC as well as Ve and Vt was noted. In most patients Vt during maximal exercise was around 50% of VC, while no such limit was present when Vt was related to FEV1. These patterns were independent of the clinical type of obstructive lung disease. At 300 kpm/min (50 W) Vt/VC% as well as heart rate was negatively correlated to V02 max, but not to FEV1. No significant relationship was seen between V02 or Ve at this exercise level and V02 max, as well as FEV1. The ventilatory pattern during exercise seemed to reflect the patients' ventilatory strain more adequately than pre-exercise FEV1. The negative relationship between heart rate during moderate exercise and V02 max might further reflect this strain.

Bronchitis↗
PubMedDate not supplied

Value of simple parameters during exercise in chronic obstructive lung disease.

The value of simple physiological parameters as heart rate and peak expiratory flow rate, and bicycle ergometer, together with electrocardiogram is emphasized. Exercise capacity, exercise induced bronchoconstriction and/or electrocardiographic abnormalities are the conditions most important to look for. Recording tidal volume and respiratory air low might give additional information about disproportion between ventilatory "drive" and "performance".

Disability Evaluation↗