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Biomedical subjects

J Scharfenberg

Publications and source records attributed to J Scharfenberg.

8 recordsLinked to original sources
PubMed1993

Metastatic pigmented neuroectodermal tumor with cranial CT-pathology correlation.

Pigmented neuroectodermal tumors are a relatively rare clinicopathologic entity, presenting in a variety of locations. Their histogenesis suggests a transformation from common pleuripotential neural crest cells with varying degrees of differentiation to neural elements and melanocytes. We present a case of just such a tumor, which presented initially in the mandible of a leukemic patient who received irradiation to the skull base, as well as systemic chemotherapy, for suspected cranial leukemic involvement. Subsequent development of intracranial spread was documented both by imaging and pathology. Extracranial spread was also found at autopsy. This unusual presentation and widespread dissemination of the neuroectodermal tumor in our case confirms its aggressiveness and potential for multifocality.

Acute Disease↗
PubMed1990

Molteno rip-cord suture hypopyon.

Seven of 27 eyes developed hypopyons following removal of a 4-0 chromic suture that had been placed intraoperatively in the lumen of the tube of a Molteno implant as a temporary occlusion device. The hypopyons were sterile to anterior chamber tap and in six of seven cases resolved with only routine antibiotic coverage. Surgeons contemplating using an internal chromic suture occlusion in Molteno implants, however, should be aware of this potential problem and adopt a conservative, noninvasive approach.

Adolescent↗
PubMed1981

Effect of PEEP on gas exchange, pulmonary mechanics, and hemodynamics in adult respiratory distress syndrome (ARDS).

The effect of positive end-expiratory pressure on a value resulting in maximum static effective compliance was studied in 13 artificially ventilated patients suffering from adult respiratory distress syndrome. Applying positive end-expiratory pressure in this manner resulted in improvement of oxygen delivery and left ventricular stroke work. In the patients with high venous admixture under zero end-expiratory pressure cardiac output increased but in those with moderate pre-existing venous admixture cardiac output decreased. We conclude that the response to positive end-expiratory pressure depends on the importance of the venous admixture. Artificial ventilation with positive end-expiratory pressure on a level resulting in maximum static effective compliance is indicated in cases with high venous admixture.

Adult↗
PubMed1980

Application of bromhexine metabolite VIII (NA 872) and bromhexine-glucose in treatment of adult respiratory distress syndrome; experimental and clinical results .

The authors study the changes in cardiopulmonary function after application of bromhexine metabolite VIII (NA 872) in an animal model of adult respiratory distress syndrome (ARDS) and bromhexine glucose solution (BGS) in ARDS patients. After damage of the lung alveolar surfactant by intratracheal atomization of 0.2 M HCl in LEWE Minipigs significant changes in lung compliance, dead space ventilation, venous admixture, alveolo-arterial oxygen tension difference, pulmonary vascular resistance, and oxygen uptake are present under application of NA 872 in comparison to untreated animals. In ARDS patients treated with BGS, pulmonary function is significantly ameliorated indicated by changes in static effective compliance, oxygen exchange ratio, and alveolo-arterial oxygen tension difference.

Animals↗
PubMed1979

The prognostic value of intracranial pressure monitoring after severe head injuries.

ICP monitoring appears not to be essential for the prognosis of head injury patients, but it may be of some clinical value in association with the neurological status and other clinical data. The results of ICP measurement show that a high level in brain pressure and the poor outcome have a better correlation with one another than a lower level of brain pressure and a good recovery.

Adolescent↗