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Biomedical subjects

J Scheele

Publications and source records attributed to J Scheele.

At least 73 records · Page 4Linked to original sources
PubMed1987

Initial experience with the endoscopic application of fibrin tissue adhesive in the upper gastrointestinal tract.

During a 15-month period, a total of 11 patients underwent endoscopic application of fibrin tissue adhesive in the upper gastrointestinal tract. Our sample consisted of 6 patients with control of bleeding, 4 patients with management of anastomotic leaks, and one very old man undergoing prophylactic sealing of a chronic gastric ulcer with a visible vessel and repeated episodes of bleeding. The method described has proven to be successful in control of bleeding in every case and has resulted in quick cleaning of perianastomotic abscess cavities, growth of granulation tissue, and complete healing in 3 of 4 cases so far. This preliminary report suggests that fibrin adhesive application is effective in the control of oozing gastrointestinal bleeding and may support the healing process in difficult situations, such as chronic peptic ulcers and anastomotic leakages.

Adult↗
PubMed1986

[Differential indications of conservative and surgical possibilities of treating splenic rupture].

Conservative therapy of splenic trauma in the adult cannot be recommended, since 2/3 of patients with polytrauma will prove to have additional abdominal organ lacerations. The new methods of local haemostasis, suture and partial resection and their application and contraindications according to Barrett's classification of splenic trauma are discussed. Our own salvage rate has been 50% (70/140) in trauma and 77% (116/151) in iatrogenic lacerations during the past 5 years.

Aprotinin↗
PubMed1985

Studies on the mechanism of cytotoxicity of 3-deazaguanosine in human cancer cells.

The mechanism of toxicity of 3-deazaguanosine was studied in a number of human tumor cell lines by determination of the effects of various purine compounds on the growth of the cells in the presence of the drug and by studies of the effects of 3-deazaguanosine on the metabolism of radiolabeled precursors in these cells. The drug was found to be toxic to all of the cell lines tested. The toxicity was reversible with removal of the drug. None of the purine bases tested could restore normal growth after 48 h exposure to 3-deazaguanosine; the bases were more effective in preventing cytotoxicity when added simultaneously with the drug. Metabolic studies indicated decreased synthesis of DNA, variable inhibition of de novo purine synthesis, and complete inhibition of the enzyme guanosine monophosphate reductase by 3-deazaguanosine.

Adenine↗
PubMed1985

[Effect of anastomosis technic on wound healing in the gastrointestinal tract. Animal experiment study of the dog colon with special reference to manual suture technics].

Three manual suture techniques (double-layer inverting, single-layer end-to-end, and continuous suture of the submucosa) were compared with anastomoses performed by stapling instruments (EEA, KZ 28) on the canine colon. The two manual techniques with exact end-to-end apposition led to primary wound-healing during the early postoperative period (3-20 days). There was no significant stenosis at the site of anastomosis five and ten months postoperatively. Inverting sutures as well as stapled anastomoses, however, showed delayed healing with considerable inflammatory reaction, resulting in marked stenosis after five to ten months.

Animals↗
PubMed1984

Splenic repair by fibrin tissue adhesive and collagen fleece.

A new biogenic tissue adhesive has been used for repair of traumatic and incidental splenic lesions in 108 patients. The theoretical basis of fibrin adhesive application and technical details of this method, including the combination with a collagen fleece, are described. Complete hemostasis was achieved in 100 patients. In incidental splenic lesions the success rate of the method was 94%, and the overall salvage rate 87%. The corresponding figures for traumatic lesions were 87% and 60%, respectively. Postoperative complications developed in five patients, necessitating relaparotomy in four. In three of these patients complications were not related to the splenic repair. It can be concluded that the use of fibrin tissue adhesive is a safe and reliable method for repair in the majority of incidental and traumatic splenic injuries.

Adolescent↗
PubMed1982

[Anastomotic technique in tracheal resection. Animal experiments (author's transl)].

In 24 rabbits and 6 dogs, two subtotal tracheal transsections each were reanastomosed using Dexon , Vicryl, Prolene and Mersilene in running or interrupted suture technique. In order to avoid traumatisation of the perichondrium, sutures included the marginal cartilagenous ring and all layers of the tracheal wall. By putting every second stitch in a 8-figure, an ideal adaptation could be achieved. Half of the anastomoses were secured by additional application of fibrin tissue adhesive. Macroscopical and histological examinations were carried out 5, 10, 21 and 63 days postoperatively. Mersilene resulted in remarkable inflammatory tissue reaction - increasing from the 5th day on - leading to extensive granulomas, abscesses, ulcerations of the mucosa and erosion of the cartilage. In contrast, by using synthetic absorbable materials as well as prolene, minimal tissue reaction occurred with an even and delicate scar formation. The findings do not support the view, that an extramucosal stitch technique is essential. The additional sealing with fibrin tissue adhesive increased the safety of the anastomoses during the early postoperative period.

Animals↗
PubMed1982

[Successful reconstruction of the completely transsected hepato-duodenal ligament. Case report on ischemia tolerance of the human liver].

Incidental complete transsection of the hepato-duodenal ligament occurred in a 59-year-old female patient during gastric surgery. More than three hours later reconstruction of the portal vein, hepatic artery and common bile duct was started, performing end-to-end anastomoses in all cases. The time interval between transsection and restoration of blood flow was 225 minutes for the portal vein and 255 minutes for the right hepatic artery. The left hepatic artery could not be reconstructed. The postoperative course was unremarkable clinically, however, there was an extreme initial rise in the levels of SGOT, SGPT, LDH, and alpha-amylase, followed by a somewhat delayed jaundice with bilirubin levels above 10 mg/dl. In-hospital follow-up examinations were performed 6 and 13 month postoperatively. They revealed good clinical condition, patent blood vessels, slight displacement of the biliary anastomosis by scar tissue without functional stenosis and gradual normalisation of biochemical parameters. The left hepatic lobe became initially necrotic, later atrophic.

Constriction↗
PubMed1981

[Importance of peritoneal lavage in the diagnosis of blunt abdominal trauma (author's transl)].

Peritoneal lavage was carried out in 830 patients with blunt abdominal trauma. Positive as well as negative results proved to be very reliable (98% and 99.5% accuracy). With weakly positive findings, however, significant internal injuries were present in only half of the cases. If compared to circulatory parameters, laboratory investigations and clinical evaluation of the abdomen at the time of hospitalization, peritoneal lavage proved to be the superior aid in making a decision to operate. It therefore should be used routinely--even in smaller hospitals--especially before transferal of a patient to a distant special surgical center.

Abdominal Injuries↗
PubMed1981

[The use of fibrin tissue adhesive in parenchymal organs of the abdomen. An experimental study in rabbits and dogs (author's transl)].

In rabbits and dogs standardized lesions of the liver, kidney, and spleen were treated by application of human fibrinogen tissue adhesive. In all cases this procedure resulted in a complete control of bleeding as well as a stable and lasting closure of the wounds. During the postoperative observation time of one month, the fibrinogen tissue adhesive was initially infiltrated by leucocytes and macrophages and subsequently resorbed by a granulating tissue, characterized by the early appearance of numerous fibroblasts. Our clinical experience, until now, confirms these promising experimental results.

Animals↗
PubMed1981

[Risk of hepatitis in fibrin adhesion (author's transl)].

A prospective trial was performed on 146 patients, in whom fibrin tissue adhesive was applied during operations. 130 patients, who had received no fibrin glue, served as a control group, and were submitted to the same examinations as the first group of probands. In both groups we could not see any infections with hepatitis B.

Alanine Transaminase↗