Biomedical subjects

J Schots

Publications and source records attributed to J Schots.

3 recordsLinked to original sources

PubMed1994

Blood usage review in a Belgian university hospital.

The appropriate use of whole blood, packed red cells (PRC), fresh-frozen plasma (FFP) and platelets was evaluated. The indications, effectiveness and complications of transfusion were determined on the basis of existing criteria described in the literature and prevailing practices in the hospital. A retrospective review of medical records demonstrated that the administration of PRC was unnecessary in 15% of the cases and that the use of FFP was not indicated in 67% of the patients. The result of PRC transfusion was inadequate in 4% of the cases. Haemolysis and circulatory overload occurred in 2% and 4% of the patients, respectively. Major hazards such as Acquired Immunodeficiency Syndrome (AIDS) and hepatitis were not observed. In order to improve the appropriate use of blood components, transfusion guidelines were proposed to all medical departments.

Blood Transfusion↗

PubMed1992

Method-dependent differences in apparent sodium concentrations in plasma after exchange transfusions with citrated blood.

Shortly after exchange transfusions (n = 7) with citrate-dextrose-phosphate (CDP)-treated blood, but not after regular transfusions (n = 9), sodium concentrations in plasma were significantly and paradoxically lower (3-10 mmol/L) by Ektachem 700 XR determination [with use of electrolyte reference fluid (ERF) generation 00] than by flame photometry. Similar between-method differences could also be generated by in vitro supplementation of plasma pools with CDP solution, with trisodium citrate, or to a lesser extent with Na2HPO4. For four potentiometric methods the analytical recovery of sodium added as CDP was significantly lower than by flame photometry. Within each potentiometric method the recovery was also less than the value for sodium added as NaCl. A significant association of sodium ions with citrate3- ions and, to a lesser extent, HPO4(2-) ions could theoretically account for at least part of the observations, conferring greater medical relevance to potentiometric measurements in this particular clinical situation.

Citrates↗

PubMed1992

Ektachem slides for direct potentiometric determination of sodium in plasma: effect of natremia, blood pH, and type of electrolyte reference fluid on concordance with flame photometry and other potentiometric methods.

With electrolyte reference fluid (ERF)00, results from Kodak Ektachem slides for the direct potentiometric assay of sodium in plasma were significantly correlated with results from flame photometry, but also appeared to be systematically higher, especially in hypernatremic patients. Indirect potentiometry with the Technicon RA-1000 yielded intermediate values. In 23 hypernatremic patients with greater than or equal to 6 mmol/L difference in sodium between Ektachem ERF00 and flame photometry, a clinical survey disclosed the frequent association of large between-method differences with renal failure, diabetes mellitus, and gastrointestinal disease. However, there was no correlation between differences in sodium on the one hand and anion gaps or (lipo)protein concentrations on the other, nor did in vitro addition studies implicate metabolites that often accumulate in the above-mentioned disorders. Unlike indirect methods, sodium measurements by direct potentiometry on Ektachem and Corning were influenced by in vitro changes of pH between 7.0 and 7.9. However, in a group of patients that included many acidotic individuals, between-method differences in sodium appeared not significantly correlated with in vivo blood pH. Use of the equitransferant ERF04 on Ektachem strongly diminishes the systematic differences with flame photometry, reduces the pH-dependency of the results to that of the direct Corning method, and brings the mean analytical recovery of sodium to below 95% (instead of 115% previously) without affecting the ability of Ektachem slides to avoid spuriously low results in the presence of increased (monoclonal) protein concentrations.

Blood↗