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Biomedical subjects

J Schuberth

Publications and source records attributed to J Schuberth.

35 records · Page 2Linked to original sources
PubMed1972

Cerebrospinal fluid choline in extrapyramidal disorders.

Cerebrospinal fluid from patients with Parkinson's disease and Huntington's chorea has been investigated with regard to the concentration of choline. In Parkinson's disease the choline concentration of lumbar spinal fluid was not different from that of a control group, nor was it related to medication, duration of illness, or severity of symptoms. A comparison between choline in ventricular cerebrospinal fluid from patients with Parkinson's disease and with intention tremor showed no significant differences. Patients with Huntington's chorea had a lower concentration of choline in lumbar spinal fluid as compared with a control group. The results are discussed in relation to the possible sources of cerebrospinal fluid choline.

Acetylcholine↗
PubMedDate not supplied

Is urine a suitable material for the preliminary screening of drugs in autopsy cases?

This paper reports a survey of drug screening in the urine specimens of 45 autopsy cases whose livers contained medicinal substances. The extractions were carried out by a solid phase/liquid technique and the analyses by thin-layer chromatography. Nine compounds out of 43 actually present in the liver were not detectable in the urine; eight cases with high drug concentrations in the liver and also in the blood would have evaded the intoxication suspicion had the urine been used as the only material for the chemical survey. On the basis of these data we advocate that the preliminary drug screening of medical-examiner cases not be carried out on urine alone.

Chromatography, Thin Layer↗
PubMedDate not supplied

A procedure for simultaneous screening and quantification of basic drugs in liver, utilizing capillary gas chromatography and nitrogen sensitive detection.

This paper describes a method used for the comprehensive screening of 80 and quantification of 49 basic drugs or drug metabolites in liver specimens taken from medical examiner's cases. A simple, versatile liquid/liquid extraction procedure was employed, and the analysis was carried out by glass capillary gas chromatography with nitrogen specific detection. In this procedure, a 15 m AR-glass capillary leached with HCl, deactivated with cyclic siloxane and coated with SE-52 was utilized. Data on precisions from the quantitative analyses carried out within-day or day-to-day yielded standard deviations on the order of 2-5% and 5-25% of the mean values, respectively, when performed at concentration levels of 10 or 100 micrograms drug per gram wet liver tissue.

Chromatography, Gas↗
PubMedDate not supplied

Evaluation of Achilles tendon rerupture.

The authors found that after either surgical or conservative treatment ankle dorsiflexion played a significant role in patients with reruptures and also in those who did not rerupture. They believe that patients who are either casted or treated by surgical repair with their foot in equinus may have a greater chance of rerupture.

Achilles Tendon↗