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J Sciuk

Publications and source records attributed to J Sciuk.

At least 37 records · Page 2Linked to original sources
PubMed1996

Use of various diagnostic methods in a patient with Gaucher disease type I.

A series of plain radiographs, bone scans, bone marrow scans, and MRIs is reported in a patient with Gaucher disease type I, in whom two episodes of acute bone crisis developed during a 6-year period of follow-up. Acute bone crisis and global indolent bone marrow displacement could both be assessed by bone marrow scintigraphy, whereas MRI could better clarify the corti-comedullary alteration after bone infarction. Thus, MRI and bone marrow scintigraphy could be used as complementary imaging methods in the management of patients with Gaucher disease.

Acute Disease↗
PubMed1996

[Positron emission tomography for primary tumor detection in lymph node metastases with unknown primary tumor].

In a prospective study 16 patients with cervical lymph node metastases from an occult tumor were analyzed by (18F)FDG positron emission tomography (PET). The aim of this study was to locate the primary tumor. In 7 patients a localized increase in activity was seen on PET, with this site of activity histologically proven in 4 patients. No biopsies were taken in 3 patients in areas with a high risk of complications. In a follow-up procedure at 2-22 months after primary radiation therapy in the other 9 patients, no primary tumor has been identified to date.

Biopsy↗
PubMed1996

Structure distribution relationship of iodine-123-iodobenzamides as tracers for the detection of melanotic melanoma.

UNLABELLED: The influence of systematic structure variations on the biodistribution of positional isomers of N-(N'-dialkylaminoethylene)-[123I]iodobenzamide (ABA) derivatives in melanoma-bearing animals was investigated. METHODS: Radioiodination of six bromo benzamide precursors was achieved by Cu(1)-assisted nonisotopic halogen exchange. Organ distribution, scintigraphic and metabolic studies were performed in nude mice bearing a human melanotic MM (SK-MEL 25). A patient suffering from melanotic melanoma underwent scintigraphy with a [123I]iodobenzamide. RESULTS: High radiochemical yields of 80%-95% and specific activities of > 5 TBq/ mumole were obtained. Animal studies revealed specific tumor uptake of all compounds with longest retention of the most lipophilic derivative p-[123I]ABA 2-2. At shorter times, however, o-[123I]ABA 2-2 exhibited the highest tumor uptake (8.9% ID/g, 1 hr p.i., 10.9% ID/g, 4 hr p.i.). Metabolization of o-[123I]ABA 2-2, mainly to o-[123I]iodohippuric acid (OIH), followed by fast renal excretion of the metabolites lead to tumor/nontumor ratios (T/NT) of > 400 for tumor/blood, and > 70 for tumor/liver at 48 h p.i. Unknown metastases could be localized in a patient using o-[123I]ABA 2-2. CONCLUSION: The effects of the structure variation of iodobenzamides on their lipophilicity, metabolism and thus pharmacokinetics lead to the suggestion of o-[123I]ABA 2-2 as a favorable melanoma imaging agent.

Animals↗
PubMed1996

Simultaneous evaluation of fatty acid metabolism and myocardial flow in an explanted heart.

UNLABELLED: The biodistribution of the fatty acid analog [131I]PHIPA 3-10, was compared to the flow tracer 99mTc-sestamibi by quantitative analysis in a dual-isotope study performed during a heart transplantation. METHODS: Iodine-131-PHIPA 3-10 and 99mTc-sestamibi were injected simultaneously approximately 20 min prior to the start of surgical procedure. Scintigraphic images of the sliced explanted heart were compared to the preoperative in vivo scans using [123I]PHIPA 3-10, 201TI and 99mTc-sestamibi. In 14 tissue samples of the explanted heart, the radioactive contents from [131I]PHIPA 3-10 and 99mTc-sestamibi were calculated as %ID/g-values and correlated with the corresponding histology. RESULTS: In the preoperative scans, a mismatch of fatty acid uptake and perfusion ([123I]PHIPA 3-10 > flow) was observed which indicated residual viable myocardium, while a matched defect was associated with scar. In viable myocardium, there was a significantly higher accumulation of [131I]PHIPA 3-10 compared to 99mTc-sestamibi (mean 5.9 x 10(-3) versus 2.7 x 10(-3)%ID/g),whereas in scars the uptake of both tracers was comparable (1.2 x 10(-3) versus 1.4 x 10(-3)%ID/g). CONCLUSION: Myocardial viability can be defined more accurately with radioiodinated PHIPA 3-10 than with 99mTc-sestamibi. The differences of biodistribution in viable myocardium and scars indicate that not only perfusion but also the metabolic state of the myocardium can be evaluated with radioiodinated PHIPA 3-10.

Coronary Circulation↗
PubMed1995

Synthesis, characterization and biodistribution of neutral and lipid-soluble 99mTc-bisaminoethanethiol spiperone derivatives: possible ligands for receptor imaging with SPECT.

Using parts of the molecular structure of spiperone, two new ligand systems for complexation with [99mTc]technetium were prepared in order to develop potential receptor imaging agents for single photon emission computer tomography (SPECT). The bis-aminoethanethiols (BAT): 1-benzyl-4-(2-mercapto-2-methyl-4-aza-pentyl)-4-(2-mercapto-2-methyl- propylamino)-piperidine (benzylpiperidyl-BAT, BP-BAT) and 1-[3-(4-fluorobenzoyl)-propyl]-4-(2-mercapto-2-methyl-4-aza-pentyl)-4- (2-mercapto-2-methyl-propyl-amino)-piperidine (butyrophenoylpiperidyl-BAT, BUP-BAT) form stable, neutral and lipid soluble complexes with [99mTc]technetium at pH > or = 11 using SnCl2 as reducing agent in nearly quantitative radiochemical yields. Biodistribution of 99mTc-BP-BAT and 99mTc-BUP-BAT in rats showed a moderate clearance from blood and low uptake and retention in the liver, whereas brain uptake was moderate, however with prolonged brain retention. On the other hand, significant accumulations and retentions were observed in heart, kidney and lung with increasing oxygen/blood ratios up to 24 h. Within 24 h p.i. 22 and 29% of the injected dose (i.d.) of 99mTc-BP-BAT and 99mTc-BUP-BAT were eliminated by hepatobiliary excretion whereas 22% i.d. of both 99mTc-BAT complexes were excreted into the urine. Although first biodistribution studies of 99mTc-BP-BAT and 99mTc-BUP-BAT in rats showed relatively low brain uptake, the high uptake in peripheral, receptor rich organs indicates that compounds of this type may be used as a basis for further structural modification to develop agents with optimal properties for cerebral or peripheral receptor imaging with SPECT.

Animals↗
PubMed1995

[The diabetic foot].

Foot disease in patients with diabetes mellitus is multifactorial and results from a combination of peripheral neuropathy, vascular compromise and superimposed infection. Foot complications in diabetic patients are common and account for more hospital days than any other aspects of their disease. Therefore, familiarity with the spectrum of findings in the different imaging modalities appears essential. Radiographically, significant changes include Charcot joints of the tarsus (destructive type) and bone absorption of the forefoot (mutilating type). In diabetic foot problems, magnetic resonance imaging and leukocyte scintigraphy appear to be the most effective tools for detection of osteomyelitis, and a negative study makes osteomyelitis unlikely. However, the findings of both techniques in active, noninfected neuropathic osteoarthropathy may be indistinguishable from those of osteomyelitis.

Arthropathy, Neurogenic↗
PubMed1995

[67Ga scintigraphy in acute sarcoidosis with Heerfordt's syndrome].

Sarcoidosis is a chronic multisystem disorder of unknown etiology characterized by non-caseating epitheloid granulomas. We report a case of a 29-year old female with acute sarcoidosis and Heerfordt's syndrome (parotid enlargement, anterior uveitis and facial nerve palsy) who had a typical clinical constellation but no histologic criteria of a granulomatous inflammatory process in transbronchial lung biopsy. 67Ga scintigraphy revealed such a typical pattern of accumulation that sarcoidosis could be diagnosed despite negative histological findings.

Adult↗
PubMed1995

[Spinal metastases. Value of diagnostic procedures in the initial diagnosis and follow-up].

In this retrospective study plain radiographs, radionuclide bone scans, computed tomography (CT) and magnetic resonance (MRT) examinations of 115 patients with metastatic carcinoma of the spine were analyzed. In 32 patients metastases were proven histologically and in the remainder by follow-up studies. Altogether, 513 vertebrae were evaluated. Forty-one patients had histologically proven breast cancer, 14 renal cell carcinoma, 11 prostate cancer, 8 melanoma. 8 tumors of the gastrointestinal system and 7 bronchial carcinoma. Evaluation of the plain films showed that the initial site of metastasis (n = 463) was the vertebral body in 441 cases and the pedicles in 294 cases. In CT scans most of the lesions confined to one part of the vertebral body (36 of 98) were localized in the posterior part. Twelve percent of the metastases were diagnosed with conventional radiography and 17% of those diagnosed with CT were not detected in skeletal scintigraphy. MRI was rarely used in diagnosing occult vertebral metastases (n = 37); 22% of the metastases demonstrated by MRI were not detected in skeletal scintigraphy. We concluded that only in 63.8% was the pedicle sign the initial site of metastasis on plain films. Bone scans and plain films are the most important diagnostic procedures for detecting and monitoring vertebral metastases. CT and MRI are only needed in patients with neurological symptoms and persistent pain.

Diagnostic Imaging↗
PubMed1994

Scintigraphic detection of osteomyelitis in osteopetrosis.

METHODS AND RESULTS: The diagnosis of osteomyelitis in severe osteopetrosis may be difficult since altered bone architecture and fractures veil the typical radiographic signs of inflammation. We present a case of adult osteopetrosis with questionable clinical and radiographic signs of two osteomyelitic foci in the foot. CONCLUSION: Despite severe skeletal disease, the combination of skeletal and leukocyte scintigraphy suggested the diagnosis of infection.

Bone and Bones↗
PubMed1993

N-(2-diethylaminoethyl)-4-[123I]iodobenzamide as a tracer for the detection of malignant melanoma: simple synthesis, improved labelling technique and first clinical results.

In order to evaluate the behaviour of N-(2-diethylaminoethyl)-4-[123I]iodobenzamide in malignant melanotic disease, we synthesized the bromo compound in a simple one-step reaction. Labelling was performed by non-isotopic bromine-iodine-123 exchange in radiochemical yields up to 60%. By means of isocratic high-performance liquid chromatography, the iodinated product could be isolated with high apparent specific activity. First clinical studies in patients with malignant melanoma using N-(2-diethylaminoethyl)-4-[123I]iodobenzamide showed moderate uptake of the tracer in the tumour and the suspected metastases in all patients. Most of the lesions were detectable with technetium-99m-diethylene triamine penta-acetic acid (DTPA) scintigraphy too, but we were able to detect additional, previously unidentified metastases with benzamide scintigraphy. This changed the therapeutic procedure in two of the five cases investigated so far.

Aged↗
PubMed1993

Intraoperative, probe-guided curettage of osteoid osteoma.

The only curative approach for osteoid osteoma is operative removal of the nidus, but intraoperative detection of the nidus is difficult even when an X-ray amplifier is used. A simple probe-guided operative procedure using technetium-99m methylene diphosphonate is described, and the results and follow-up in 12 patients are reported. In addition physical properties of the probe have been evaluated by phantom measurements.

Adolescent↗
PubMed1993

Effective renal plasma flow in patients with glycogen storage disease type I.

To evaluate effective renal plasma flow (ERPF) we performed renal scintigraphies with 99mTc-Mercaptoacetyl-triglycine (MAG3) in nine patients with glycogen storage disease I (GSD I) (age: 16 +/- 7 years). Two patients presented with proteinuria, none showed hyperaminoaciduria, disturbed tubular reabsorption of phosphate or hypertension. 99mTc-MAG3 clearance values were elevated in eight out of nine patients (865 +/- 233 ml/min/1.73 m2 body surface area) and exceeded the age-dependent mean values by 21%-145%. ERPF values in patients with poor metabolic control were higher than in patients with long-term good metabolic control (988 +/- 186 vs. 619 +/- 55 ml/min/1.73 m2; P < 0.05). We conclude that enhanced ERPF is a common finding in GSD I patients, which precedes clinically overt nephropathy. Renal scintigraphy with 99mTc MAG3 is a suitable method for the early detection and monitoring of kidney dysfunction in GSD I.

Adolescent↗
PubMed1992

White blood cell scintigraphy with monoclonal antibodies in the study of the infected endoprosthesis.

Forty-three patients with suspected infection of a hip or a knee prosthesis were studied with white blood cell scintigraphy (WBC), using technetium-99m (n = 37) or iodine-123 (n = 6) labelled monoclonal mouse antibody (MoAb). Previously, all patients had undergone skeletal scintigraphy, which was performed as a three-phase study in 33 cases. The final diagnosis was established by open surgery, histology and culture in 37 cases, by puncture and culture in 3 cases, and by clinical follow-up of at least 6 months in 3 cases. Eighteen prostheses were infected, 25 uninfected. The delayed phase of skeletal scintigraphy had a sensitivity of 92%, a specificity of 24% and an accuracy of 48% in the detection of infection. The perfusion and blood pool activity of the three-phase bone scan had a sensitivity of 67%, a specificity of 71% and an accuracy of 70%. The diagnostic value of WBC was sensitivity 89%, specificity 84% and accuracy 86%. WBC with 99m-Tc-MoAb is easy to perform and always available. Its diagnostic accuracy is similar to conventional WBC scintigraphy with either indium-111 or technetium-99m.

Adult↗
PubMed1992

Characteristic EEG findings in childhood moyamoya syndrome.

Moyamoya syndrome-specific alterations of EEG recordings are only observed in children. These consist of a gradual frequency decrease and amplitude activation after hyperventilation. This is referred to as re-build-up phenomenon. Thus, a tentative diagnosis of Moyamoya syndrome in children can be based on the EEG finding. This should be radiologically confirmed by angiography.

Cerebral Angiography↗
PubMed1992

[Dynamic MR tomography in the diagnosis of inflammatory and tumorous space-occupying lesions of the musculoskeletal system].

In 216 inflammatory and tumorous lesions of bone and soft tissue, dynamic Gd-DTPA enhanced MR imaging was performed. For that purpose, 12 FLASH sequences (TR = 40 ms/TE = 10 ms/NSA = 2/flip angle = 90 degrees) were acquired within 4 minutes; and Gd-DTPA bolus injection was administered following the first sequence. Slopes from the signal intensity curves were calculated. Estimated slopes allowed an assessment of the malignant potential of a lesion with an accuracy of 88%. Further more, a reliable differentiation between vital and necrotic tissue and between tumour and peritumoral edema was reliably possible. With this technique, response of malignant tumours to preoperative chemotherapy was correctly predicted in 83% of the cases. No differentiation of inflammatory from tumorous lesions was possible.

Bone Neoplasms↗
PubMed1992

[Cortical dysplasia as an epileptogenic focus: reduced binding of 123I-iomezanil with barely perceptible 99mTc-HMPAO SPECT].

In cortical areas associated with an epileptic focus, there is, in the majority of cases, a correlation between decreased benzodiazepine (Bz) receptor binding, detectable with 123I-Iomazenil, and decreased blood flow. A patient with focal epilepsy due to a localized abnormality in cortical differentiation is presented who showed a marked focal decrease in Bz receptor binding and a normal 99mTc-HMPAO SPECT. Based on this case the relation between blood flow and Bz receptor binding in epileptic foci is discussed.

Cerebral Cortex↗