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Biomedical subjects

J Seggie

Publications and source records attributed to J Seggie.

22 records · Page 2Linked to original sources
PubMed1976

Twenty-four-hour resting prolactin levels in male rats: the effect of septal lesions and order of sacrifice.

Diurnal variation in resting prolactin levels was studied in male rats that were normal, sham-operated, or lesioned in the septal nuclei. Separate groups of rats were sampled by decapitation every 3 or 4 hours in two separate studies during a 24 h period consisting of 12 h light and 12 h dark. Male rats did not exhibit a significant diurnal variation in resting prolactin levels. A septal lesion had no effect on resting prolactin levels. Prolactin levels were found to be highly responsive to environmental disturbances and were subject to the effects of sequential sacrificing procedures. The possibility was raised that prolactin exhibits a diurnal variation in sensitivity to stress which varies as a function of circulating levels of corticosterone.

Animals↗
PubMed1976

Coping with stress: parallelism between the effects of septal lesions on growth hormone and corticosterone levels.

In order to characterize the effects of a septal lesion on plasma growth hormone levels, blood samples were taken from normal and sham-operated rats and rats with a bilateral septal lesion under conditions of rest and following stressful stimulation. Nonlesioned control rats evidenced a significant base line diurnal rhythm in plasma growth hormone levels which was unaffected by a septal lesion. In response to stress, plasma growth hormone levels evidenced a significant drop. Minimum levels were reached 15 min after stimulation and remained depressed during 1 hr of observation after stimulation. Rats with a septal lesion evidenced the same pattern of growth hormone response to stressful stimulation as nonlesioned rats, however the magnitude of response was potentiated in septal rats. The present data were compared to the previously published corticosterone data from the same animals. A septal lesion has similar effects on boting 24-hour rhythm of either of these hormones but potentiated the response of both corticosterone and growth hormone to stress even though the direction of response is opposite. The results are interpreted as suggesting the septum is an element in some central coping mechanism which is involved when an organism reacts to environmental demands. Preliminary data further suggest that the same central coping mechanism is involved in both the behavioral and hormonal responses to stress.

Animals↗
PubMed1975

Serum alpha-feto protein (alpha-FP) and hepatoma in Rhodesian Africans.

Alpha-feto protein (alpha-FP) is now accepted as a very useful serum marker of hepatocarcinoma, and since its discovery in 1963, surveys have been carried out in various regions of the world, where hepatoma is particularly prevalent, which have shown that alpha-FP may be detected in 50 to 80% of patients with liver cancer. The sera of 30 Rhodesian African patients with histologically proven hepatoma were tested in this study for the presence of alpha-FP. In only 47% was alpha-FP detected. Thus it is our experience that a positive result is strong evidence in favour of a diagnosis of hepatocarcinoma whilst a negative result is of little value, necessitating that liver biopsy be carried out in all patients with clinical suspicion of liver cancer.

Adolescent↗