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Biomedical subjects

J Seror

Publications and source records attributed to J Seror.

At least 19 recordsLinked to original sources
PubMed2005

Use of Sengstaken-Blakemore tube in massive postpartum hemorrhage: a series of 17 cases.

BACKGROUND: To evaluate the efficacy and identify the indications of intrauterine tamponade with a Sengstaken-Blakemore tube in acute postpartum hemorrhage. METHODS: Retrospective study was performed in 17 female patients with massive postpartum hemorrhage despite appropriate medical treatment, and requiring surgery (embolization techniques were not available in our hospital). Patients were treated by inserting a Sengstaken-Blakemore tube in the uterus through the vagina in case of vaginal delivery or through the hysterotomy incision in case of cesarean section. The esophageal balloon was inflated with 250 ml of isotonic saline solution. Patients underwent regional or general anesthesia. A preventive treatment with broad-spectrum antibiotics was systematically administered. RESULTS: Tamponade treatment prevented surgery in 88% of patients, hemorrhage was controlled in 71% of cases (reducing the need for embolization by 80%), and waiting for a transfer for embolization was made possible for 18% of patients. CONCLUSION: Intrauterine tamponade with a Sengstaken-Blakemore tube appears as a simple, low-cost, readily available and effective means of treating life-threatening postpartum hemorrhage. The only apparent contraindication is the discovery of an infection during delivery.

Acute Disease↗
PubMed2003

Interaction between nitric oxide and prostanoids in arterioles of rat cremaster muscle in vivo.

We studied in vivo interactions of nitric oxide (NO), oxidative stress, and prostanoids derived from the cyclooxygenase pathway in the arterioles studied by intravital microscopy in peripheral muscle. Topical administration of NO synthase (NOS) inhibitor Nomega-nitro-l-arginine (l-NNA) or cyclooxygenase inhibitor mefenamic acid (MA) alone leads to vasoconstriction. We found that l-NNA after MA induced an additional constriction, whereas MA after l-NNA induced a relative dilation. Therefore, an additional constriction was found when MA was administered after l-NNA in the presence of the thromboxane A2 synthase-PGH2 (TP) receptor antagonist SQ-29548. We also found a relative dilation when the TP receptor antagonist was administered after NOS inhibition by l-NNA. In the presence of superoxide dismutase and catalase, l-NNA-induced vasoconstriction is reduced, and the dilation observed after addition of MA in presence of the reactive oxygen species is no longer present. Taken together, these results showed that NO inhibition induced a shift in the synthesis or in the effects of cyclooxygenase products, in favor of constrictor prostanoids. This effect of NO inhibition disappears when reactive oxygen species are scavenged by superoxide dismutase and catalase.

Animals↗
PubMed2003

[Febrile pseudotumor lesion of the arm. Atypical presentation of Shulman syndrome]].

INTRODUCTION: The diagnostic approach when confronted with a pseudo-tumoral lesion and fever is difficult since it evokes an infectious, rheumatismal inflammatory or even systemic disease. OBSERVATION: A 39 year-old Vietnamese man was hospitalised for polyarthralgia if the arm and fever (39 degrees C). He was treated with non-steroidal anti-inflammatories, which were only partially effective. Biological examinations revealed a severe inflammatory syndrome and cytolysis three-fold higher than normal. Since the infectious, rheumatismal and immunological explorations were negative and in view of the appearance of a pseudo-tumoral inflammatory lesion of the left arm concomitant to infiltration of the underlying muscle revealed on MRI, a muscle biopsy was performed showing eosinophilic fasciitis. Diagnosis of Shulman's syndrome was made and the affection rapidly improved with corticosteroids. COMMENTS: The presentation of our patient was atypical for several reasons: his Vietnamese origin, the initial fever peak at 39 degrees C, the unilateral involvement, the severe inflammatory syndrome, the initial absence of hypereosinophilia, the visceral involvement and notably myositis are all uncommon in Shulman's syndrome. Hence, it is important to rule out its differential diagnosis from local edematous scleroderma, which does not share the same prognosis.

Adult↗
PubMed1978

Operative injuries to the bile ducts. Report on 12 cases.

We have reported on a series of 12 operative injuries to the bile ducts. We estimate the frequency of these accidents at 0.2% during cholecystectomy and 0.4% after gastroduodenectomy. We stress the importance of systematic cholangiography during the operation to prevent unrecognized lesions. Immediate repair of these lesions by an end-to-end anastomosis appears to be the best technical method. When faced with a high mortality rate, often due to non-recognition of a lesion, we stress the importance of prevention to limit the risk of such accidents occurring and non-recognition of those that do occur.

Adult↗
PubMed1976

[Acute cholecystitis without stones (author's transl)].

The authors report on ten cases of cholecystites without stones. Two were typhic in origin, six apparently primitive, one postoperative and one posttraumatic. They stress the importance of histologic lesions in each of these etiologies and insist on the high frequency of gangrenous forms in postoperative and posttraumatic cases. Previous antibiotherapy deserves no credit. Emergency cholecystectomy remains the best treatment.

Abdominal Injuries↗