PubMed Health⌕ Search

Biomedical subjects

J Setekleiv

Publications and source records attributed to J Setekleiv.

At least 19 recordsLinked to original sources

[180 years of teaching and research in pharmcology in Oslo. The 100-year anniversary of the department of pharmacology].

The teaching of pharmacology and toxicology for medical students started in Norway 180 years ago, in 1814, when the first Norwegian medical school was founded in Kristiania (Oslo). The first professors, however, had to teach other medical disciplines in addition to pharmacology: Nils Berner Sørensen taught pathology and therapy, Fredrik Holst and Ernst Ferdinand Lochmann taught hygiene. 100 years ago, in 1894, Poul Edvard Poulsson was appointed professor in pharmacology and toxicology only. Poulsson became the founder of pharmacology in Norway and of the Department of Pharmacology. In particular, he became known for his textbook of pharmacology. The first edition appeared in 1905, and the textbook was later translated to several languages. The article reviews the early history of pharmacology in Norway, based on the biographies of the professors mentioned above and of their successors, Klaus Hansen and Jacob Molland. The Department of Pharmacology was reorganized in 1966. The most recent period is reviewed only briefly. The present status of the department and of pharmacology are emphasized.

History, 18th Century↗

Fentanyl and pethidine are antagonists on muscarinic receptors in guinea-pig ileum.

In order to evaluate the anticholinergic effect of fentanyl and pethidine, the influence of these drugs on the cumulative dose-response curves of carbacholine on the guinea-pig ileum has been investigated. Fentanyl and pethidine displaced the dose-response curve for carbacholine to the right in a parallel fashion, indicating competitive antagonism. Dissociation constants determined by an agonist EC versus antagonist plot were 0.22 mumol/l for fentanyl and 1.4 mumol/l for pethidine. It is concluded that during high-dose fentanyl anaesthesia, fentanyl may bind to muscarinic receptors and thereby produce a central anticholinergic syndrome. An additional finding was that the maximal response to carbacholine increased significantly when combined with pethidine.

Animals↗

Naloxone counteracts the fast development of tolerance to morphine in guinea-pig ileum.

The ability of naloxone to inhibit the fast development of tolerance to morphine was examined in the guinea-pig ileum preparation. Dose-response curves were obtained either non-cumulatively with morphine alone or cumulatively with morphine alone and in combination with different concentrations of naloxone. We present some theoretical considerations concerning the competitive interaction between agonist and antagonist on a receptor. According to these theories, it is possible to perform dose-response experiments for an agonist in combination with different concentrations of antagonist and extrapolate to the dose-response curve for agonist alone and to the dissociation constant for the antagonist. EC50 values for morphine alone obtained either non-cumulatively or by extrapolation are almost identical and are significantly lower than those obtained cumulatively. The results indicate that tolerance develops very quickly when dose-response curves are obtained cumulatively with morphine alone and that low concentrations of naloxone counteract the development of tolerance.

Animals↗