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Biomedical subjects

J Sikorski

Publications and source records attributed to J Sikorski.

At least 19 recordsLinked to original sources
PubMed1977

The pathophysiological changes of experimental fat embolism: early pre-hypoxaemic changes.

Glyceryl trioleate has been injected into greyhounds as a model of the fat embolism syndrome. Pulmonary vascular pressures, systemic arterial pressure and cardiac output were determined at regular intervals over an 8-hour period. It has been shown that glyceryl tioleate causes an increased pulmonary vascular resistance and a fall in cardiac output. These effects are mediated partly by a direct mechanical block of pulmonary vessels and partly through a thrombogenic property of the injected fat. The relevance of these findings to the clinical situation is discussed and a sequence of events for the fat embolism syndrome is proposed.

Animals↗
PubMed1976

Computer-based modeling in the teaching of steady-state enzyme kinetics.

Equations are derived for the steady-state treatment of enzyme reactions with one type of inhibitor, consisting of one reaction cycle or two connected cycles. Computerized stimulation programs are described which are designed to acquaint the student thoroughly with the behavior of enzyme systems. The user has freedom in the choice of parameters for the system, including up to three product-producing rate constants for the two-cycle system.

Computer-Assisted Instruction↗