Biomedical subjects

J Sims

Publications and source records attributed to J Sims.

At least 55 records · Page 3Linked to original sources

PubMed1975

The reflex sympathetic dystrophy syndrome. A comprehensive analysis using fine-detail radiography, photon absorptiometry, and bone and joint scintigraphy.

Nine patients with reflex sympathetic dystrophy were examined. Clinical manifestations suggesting arthropathy were supported by radiographic demonstration of juxta-articular and subchondral bone erosions and by radionuclide demonstration of increased activity localized in the joint regions. Aggressive demineralization was demonstrated by fine-detail radiography and consisted of endosteal and intracortical excavation and subperiosteal and trabecular bone resorption. A one-third reduction in bone mineral was confirmed by quantitative analyses. Newer modalities of study have aided in the documentation of arthropathy in reflex sympathetic dystrophy and have helped in defining the patterns of aggressive bone resorption.

Adult↗

PubMed1972

Covert sensitization with a homosexual: a controlled replication.

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Adult↗

PubMed1971

Mediastinum scanning with 75Se-selenomethionine.

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Carcinoma, Bronchogenic↗

PubMedDate not supplied

The microbial metabolism of tryptophan in rats fed a diet containing 7.5% saccharin in a two-generation protocol.

Sodium saccharin was fed at 7.5% in the diet to rats in a two-generation protocol. Saccharin-treated animals in both generations showed increased urinary excretion of indican. During lactation, the pups of saccharin-fed dams were exposed to elevated levels of indican via the milk. Establishment of the gut flora in pups at weaning in the presence of saccharin was associated with increased caecal size and caecal protein, decreased caecal tryptophanase activity, and increased urine volume and urinary indican excretion. Pups from dams fed saccharin from birth only, showed more-variable responses during the first weeks of life than pups from dams fed saccharin from before conception, due to variations in tryptophanase activity. The various biochemical and physiological changes were detected soon after the pups were weaned, and were found equally in both males and females. After adjustment for body weight, the changes detected were greatest during the first month after weaning.

Animals↗

PubMedDate not supplied

The urinary excretion of bacterial amino-acid metabolites by rats fed saccharin in the diet.

Administration of a diet containing 7.5% saccharin to adult male rats for 40 days caused a three- to four-fold increase in the daily excretion of indican and rho-cresol. Indican is formed from indole which is a microbial metabolite of tryptophan, whilst rho-cresol is formed by the gut flora from tyrosine. The excretion of phenol, which is also a microbial metabolite of tyrosine, was abolished by saccharin administration for 40 days. Analysis of urines collected at 13, 18 and 24 months during a two-generation cancer bioassay showed that these changes occur throughout the life of saccharin-treated rats. These data indicate that saccharin changes the metabolism of amino acids by the gut flora, leading to an increased formation of products known to have promoting or co-carcinogenic properties.

Amino Acids↗

PubMedDate not supplied

Human T-cell receptor beta-chain genes.

cDNA clones encoding the beta chain of the T-cell antigen receptor from the human leukaemic cell line JM (which extend through the constant region and into the variable region of the receptor) show hybridization only to RNA from JM cells, and not in five other T-cell leukaemias. Multiple hybridizing bands were detected in genomic DNA digests by a V beta probe, suggesting that inherited V beta gene diversity will be significant. Two beta-chain constant region genes (designated C beta 1 and C beta 2) occur in human genomic DNA, and both of these genes are capable of rearrangement in T-cell DNA. When the downstream C beta 2 gene is rearranged, deletion of the C beta 1 gene can occur. These characteristics of rearrangement and deletion of beta-chain genes show analogies to the immunoglobulin gene loci.

Base Sequence↗

PubMedDate not supplied

Pediatric psychopharmacologic uses of propranolol. Review and case illustrations.

This article introduces child and adolescent psychiatric nurses to the use of propranolol for aggression in children and adolescents. The use of propranolol is relatively new in the area of psychiatry. A retrospective chart review of patients who had received propranolol was conducted in an intermediate care hospital. Case illustrations are presented.

Adolescent↗

PubMedDate not supplied