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Biomedical subjects

J Skorecki

Publications and source records attributed to J Skorecki.

8 recordsLinked to original sources

Artificial encapsulation of joint prostheses.

The great success of total joint replacement in surgery has been disturbed mainly by later loosening and wear-out of the plastic components. In an attempt to improve long term performance of joint prostheses and eliminate the adverse effects of wear debris, polymeric encapsulation as a main design feature has been proposed. The benefits of having an encapsulated and artificially lubricated joint prosthesis have been evaluated in tribological terms with particular reference to the UMIST shoulder joint. The selection of a number of biopolymers involved in this research project described. The possible interactions arising from the coexistence of these materials have been mechanically investigated. Much attention and a great deal of practical work has been focussed on the sealing of the capsule and on the relevant liquid permeability.

Humans↗

Problems of encapsulation of total joint replacements.

Particulate wear debris of artificial joints, metallic and plastic, and solutions of metals in body fluids are known to have adverse effects. Encapsulation of the articulating parts would prevent wear debris from entering the surrounding tissue and check tissue ingrowth into the joint. The capsule could contain an artificial lubricant to reduce friction and wear and increase the joint life. For the capsule material, several bioelastomers are being tested in an environment of body fluids and lubricants. Three fatigue rigs have been developed for these tests. Tests have shown that a bovine synovial fluid environment causes a tenfold increase in the fatigue life of silicone rubber. A special capsule shape for minimizing stresses due to creasing is being investigated. Electrophoresis has been explored as a method of filtration of wear debris. It has been shown that Co-Cr-Mo alloy wear particles are attracted to polymers having permanent negative surface charge.

Filtration↗

The use of a kymograph in a comparative trial of flunitrazepam and meprobamate in elderly patients.

A double-blind crossover trial was carried out in 31 hospitalized elderly patients receiving night-time sedation to compare the effects of flunitrazepam (0.5 mg) and meprobamate (200 mg). After 1 week on placebo, patients received 1-week's treatment with each drug in random order. Quality of sleep was assessed by a nurse at hourly intervals over 8 hours each night. In 11 patients, the results were compared with those from kymographic recordings measuring patient restlessness (motility index). No statistically significant difference was found between the two active drug treatments, and there was a close correlation between the two methods of assessment. It is suggested that the kymograph may well be a useful and economic method of evaluating the effectiveness of hypnotics.

Aged↗