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Biomedical subjects

J Skrlin

Publications and source records attributed to J Skrlin.

4 recordsLinked to original sources

Transferable DHA-1 cephalosporinase in Escherichia coli.

Three Escherichia coli isolates resistant to third-generation cephalosporins but negative for extended-spectrum beta-lactamase production were isolated from hospitalised patients in Zagreb, Croatia, during June 2003 to February 2004. Resistance was due to the inducible production of a DHA-1 cephalosporinase. Each isolate contained an integron-associated bla(DHA-1)-ampR sequence carried by similar-sized plasmids, of which one was self-transferable. Serotyping and polymerase chain reaction typing using ERIC2 primer indicated that the isolates were distinct. This is the first description of DHA beta-lactamase production in E. coli.

Bacterial Proteins↗

Morganella morganii causing fatal sepsis in a platelet recipient and also isolated from a donor's stool.

Bacterial contamination of blood products causes significant patient morbidity and mortality. Contaminated platelet transfusion is a frequent cause of bacteraemia and sepsis because of the storage conditions of platelets. A fatal case of Morganella morganii platelet transfusion associated with sepsis is described, along with procedures traced back to the isolation of M. morganii from a donor's stool. Molecular typing was performed, and the same M. morganii strain was found in blood and post-mortem organ cultures of platelet recipient and platelet bag and in the donor's stool. The route of contamination is unknown. The contamination could be due to either insufficient venipuncture site disinfection or the donor's transient bacteraemia. Patient died 5 days after the transfusion.

Adult↗

Bacterial flora of the nasal cavity in laryngectomized patients.

In laryngectomized patients, the nose does not function. The absence of a physiological airflow stimulus leads to clinical, cytologic and histologic changes of the nasal mucosa. The aim of this study was to identify the nasal cavity bacterial flora in these patients and to determine whether or not it undergoes changes with time. In a group of 25 patients, the nasal mucosa swabs were taken before, and 8 days and 1 month after the surgery. In a group of 15 patients, the nasal mucosa swabs were taken 1 to 2 years postoperatively.

Adult↗