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Biomedical subjects

J Slaney

Publications and source records attributed to J Slaney.

5 recordsLinked to original sources
PubMed1986

A simple technique for recording and counting sweat pores on the dermal ridges.

A simple method was devised for recording dermatoglyphics in a form suitable for sweat pore counting. Fifteen members of a family with a hypohidrotic X-linked ectodermal dysplasia made their own hand prints using our method and mailed the results to us for interpretation. The simplicity of the technique also makes it practical to use on new-born males at risk for the condition, or where dermatoglyphic records are required for other purposes. Preliminary data suggest that patchiness of sweat pore distribution on the fingers and palms may be useful in the discrimination of heterozygotes.

Adolescent↗
PubMed1983

Atopy--a favourable prognostic factor for survival in Hodgkin's disease.

One hundred and forty-eight patients with Hodgkin's disease (HD) were stratified into 4 groups according to atopic status. Group 1 had a personal history of atopy and Group 2 a family history of atopy. In Groups 3 and 4 there was no history of atopy but high serum IgE levels (Group 3) and normal IgE levels (Group 4). Comparison of the survival of these groups by the logrank method showed a significant trend (P = less than 0.0001) where survival was ranked Group 1 greater than 2 greater than 3 greater than 4. Known prognostic factors in HD--age, sex, stage, symptoms and histology--had to be taken into account, since their distribution differed between the atopic groups. In Group I there was more stage IA and IIA disease and less "B" symptoms, in Group 3 more nodular sclerosis histology and more "B" symptoms and in Group 4 more lymphocyte-depleted histology and a higher mean age than expected from their distribution in the combined groups. Adjustment to allow for the variation in each of the other prognostic factors and for a combination of age, symptoms and histology still showed a significant trend of survival on the basis of atopic status. The increased survival of atopic patients suggests that atopic mechanisms or the genetic basis to atopy has a protective effect in HD either directly or by interaction with treatment.

Adult↗
PubMed1981

Hypergammaglobulinaemia E in HOdgkin's disease and its relationship to atopy or a familial predisposition to atopy.

We have found a normal incidence of atopy among patients with Hodgkin's disease (HD). Atopic HD patients had serum IgE levels and allergen specificities similar to those observed in an atopic but otherwise normal population. An atopic family background increased the number of weakly positive allergen responses in otherwise non-atopic HD patients. This effect of atopic background is known to be true for normal healthy subjects. serum IgE was raised in a third of the non-atopic HD patients but they showed neither an increase in allergen specificity nor a more frequent atopic family background than patients with normal IgE. IgE was the most frequently raised immunoglobulin class and was due to its increased synthesis. We concluded that the hyper-IgE which occurs in non-atopic HD patients is distinct from the increase in allergen-specific IgE which occurs in atopy.)

Antibodies, Anti-Idiotypic↗
PubMed1977

Circulating immune complexes after repeated halothane anaesthesia.

A patient developed hepatitis after receiving three halothane anaesthetics in 22 days. Twenty-four hours after the onset of jaundice she developed an acute serum sickness syndrome with polyarthralgia, proteinuria, and transient impairment of renal function. Serum concentrations of complement components C1q, C4, and C3 were substantially reduced, and immune complexes capable of activating the complement system via the classical pathway were present in the serum and synovial fluid. A metabolite of halothane was associated with these complexes. Fourteen months after exposure to halothane her lymphocytes were stimulated in vitro by this metabolite. The conditions under which stimulation occurred were unusual--namely, a 7S fraction of the serum, presumably IgG, was necessary. Our results provide strong evidence that halothane may be immunogenic and that its immunogenicity is dependent on the non-covalent binding of one of its metabolites to plasma proteins.

Anesthesia↗