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J Slanina

Publications and source records attributed to J Slanina.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Changes in isoagglutinin titers after high-voltage therapy with the large-field technic in Hodgkin's disease patients].

In 48 patients with Hodgkin's disease, the naturally occurring isoagglutinins anti A1, anti A2 and anti B were investigated and their titer determined before commencement of radiotherapy as well as after the end of radiotherapy, and in a proportion of the patients six and twelve months after the end of radiotherapy. Radiotherapy resulted in a highly significant fall in the isoagglutinin titer amounting on average to one titer level compared to the initial value before radiotherapy. After the end of radiotherapy, there was no further fall of the isoagglutinin titers, but a marked reduction of the isoagglutinin titers was still shown six and twelve months later. A long lasting reduction of serum immunoglobulins after radiotherapy in patients with Hodgkin's disease is known from earlier investigations; this applies in particular to IgM. Since the isoagglutinins mainly belong to the IgM fraction, our finding of persistent reduction of isoagglutinin titers after radiotherapy correlates with the known long-lasting reduction of serum IgM concentration.

ABO Blood-Group System↗
PubMed1988

[Changes in concentrations of IgM, IgA and IgM immune globulins after megavolt therapy with the large-field technic in patients with Hodgkin's disease].

Investigations were continued to study the influence of radiation therapy to immune reactions in man, especially, whether this therapy suppresses humoral immune reactions in patients with Hodgkin's disease. Sera from patients with Hodgkin's disease were collected before, during and after radiation therapy. IgA, IgM and IgG were determined by Mancini technics. 40 patients with Hodgkin's disease showed mostly normal or partly elevated values of immunoglobulins before onset of radiation therapy. Radiation induced a highly significant reduction of IgM and IgA and a significant reduction of IgG, the immunoglobulin values, however, remained mostly within the lower normal range. Investigations during the following months after radiation therapy showed, that IgG returned within two months after the end of therapy to values formerly measured. IgA returned to the basic values about nine months after the end of therapy whereas reduction of IgM continued more than twelve months after the end of therapy.

Adolescent↗
PubMed1988

[Pulmonary reaction to radiation following mantle-field irradiation. Comparison of follow-up by conventional x-ray and by computed tomography].

A group of 36 patients who received mantle field irradiation for Hodgkin's disease (35 pts) or non-Hodgkin lymphoma (1 pt) were prospectively examined by plain film radiography and computed tomography (CT) for evaluation of the pulmonary reaction at the beginning and the end of the course of irradiation, and at 12 weeks, 17 weeks, and 37 weeks after the start of the mantle field irradiation. A total of 173 plain chest radiographs (p.a. and lateral view), and 167 CTs were reviewed. As in chest radiography, the pulmonary reaction to radiation seen in CT took a characteristic course with different distinguishable stages. The radiation-induced changes typically seen on on CT were reducible to three basic patterns of opacification, which sometimes appeared in combination, and had a characteristic spatial distribution. Comparison of the two imaging modalities suggest that CT should be used in special cases, while conventional plain film radiography of the chest, with the possibility of short-term controls, is still the mainstay of follow-up for patients with Hodgkin's disease.

Adolescent↗
PubMed1987

[Pulmonary reaction to radiation as depicted in chest x-rays following megavolt therapy of breast cancer].

X-ray radiographs of the thorax of 184 patients with carcinoma of the breast (treatment period 1974-1978) that were taken during radiotherapy and follow-up were examined with respect to X-ray substrate, intensity, and temporary pulmonary reaction to radiotherapy. The therapy applied was "extended-field" irradiation (5-field technique) via 4 MeV linac with total doses of 50-60 Gy and a fractionation of 5 X 2 or 4 X 2.5 Gy/week. After a characteristic latency period of 11-13 weeks without radiomorphological reactions, the first signs of pneumonitis could be observed (stage I); after 14-19 weeks, florid pneumonitis (stage II A) was noted and from week 16 to 21, florid pneumonitis with first signs of regression (stage II B) was observed. After a transitional period (stage III), the pulmonal radioreaction ended with stationary local fibrosis (stage IV). The radioreaction was classified into three stages of severity: "light" regional pneumonitis and fibrosis occurred in 20% and 39% of the cases; a "medium" one occurred in 5% and 6%; and a "severe" reaction was observed in 12% and 4% of the cases. Further expansion of mediastinal or parenchymal areas of shadow after stage II B does not correspond to the dynamic course of pulmonary radioreactions; in these cases, thoracic tumor progression or metastasis must be assumed.

Breast Neoplasms↗
PubMed1986

[Symptomatic irradiation therapy of the spleen in advanced osteomyelosclerosis].

A retrospective analysis of spleen irradiation in 25 patients with progressive idiopathic myelosclerosis (agnogenic myeloid metaplasia), treated between 1948 and 1983, shows that there is a place for the mechanical effect of irradiation being an indication for its use as a palliative measure. A decrease in spleen size of varying extent was achieved in 84% of patients, while the symptoms of abdominal compression improved in 88%. Remission period averaged 10 months. On the other hand, in all seven patients in whom a decrease in the size of the spleen might have been expected to signal an improved blood picture, the frequency of transfusion remained unchanged.

Adult↗
PubMed1986

[Radiotherapy of esophageal cancer--indications, methods and attainable results].

From 1965-1985, in the Department of Radiotherapy of the University Hospital of Freiburg 226 patients with esophageal carcinoma have been treated with primary radiotherapy at a sufficient tumor dose - 138 of them with curative and 66 patients with palliative intention. With curative irradiation the survival rates between 1 at 5 years were 28.6%, 14.1%, 8.2%, 5.8% and 3.5%. To palliative indication the 1 year survival rate was 10.4%, none of these patients reached the two years' limit. Apparently relevant prognostic factors are: length of history, overall state of health, histologic classification, tumor stage, state of clinical remission, localization of the tumor. Our findings were compared with observations between 1965 and 1985. This paper deals with the problems of pre- and post-therapeutic irradiation, in combination with chemotherapy. Indications for radiotherapy, definition of the target volume and the different techniques of radiation planning and performance are discussed, especially with reference to comparison of stimulator- and CT-assisted radiation planning. We demonstrate the possibilities of rotation therapy with an electronically controlled diaphragm device developed in our department.

Adenocarcinoma↗
PubMed1986

[Treatment of symptomatic mucinosis follicularis in mycosis fungoides using fast electrons].

Mucinosis follicularis is a chronic type of dermatosis involving the sebaceous glands and outer root sheaths, which can be differentiated into primary and secondary types. The latter - also called symptomatic mucinosis follicularis - causes therapeutic problems because of the underlying malignant lymphoma. Successful treatment using electron beams supported by etretinate is described in detail in a 40-year-old man with symptomatic mucinosis follicularis based on plaque-type mycosis fungoides. After 6 months free of skin symptoms, the mycosis fungoides lesions recurred in the overlapping borders of the irradiation fields. These lesions were treated again with electron beams. A relapse after 32 months was controlled by PUVA. Electron beam therapy is recomended in the plaque type of mycosis fungoides, especially if PUVA has no effect for some reason.

Adult↗
PubMed1985

[Pregnancy and fetal development after therapy of Hodgkin's disease].

The post-therapeutic pregnancy data of 122/244 women aged until 40 years who had been treated primarily in Freiburg i. Br. for Hodgkin's disease between 1949 and 1981 were obtained by an inquiry based on questionnaires. All of the 122 patients of the questionnaire group were in remission. 39 out of them (32%) became pregnant one or more times; 38/94 (40%) of these had been irradiated down to the promontory and 1/17 (6%) had been submitted to an irradiation including the pelvis with ovariopexy. The resulting 63 post-therapeutic pregnancies leaded to 41 normal births (65%), three premature infants (5%), two viable children suffering from malformations (3%) and five spontaneous abortions (8%). An interruption was performed in twelve cases (19%). There were no significant divergences from distributions of normal populations with regard to the percentages of normal births and negative variants, even under consideration of comparable literature reports. Neither in the questionnaire group nor in the group of 122 patients whose gynecologic data could only be evaluated by means of the medical records available, there was any indication suggesting an increased risk of morbidity or mortality.

Adult↗
PubMed1985

[Endoscopic and biopsy findings in the esophageal, gastric and duodenal mucosa before and after radiotherapy for Hodgkin's disease].

Esophago-gastro-duodenoscopies with multiple mucosa biopsies were performed before and after irradiation of the mantle field or the spleen pedicle in 13 patients with Hodgkin's disease in stage I and II. For the irradiation the photons of a 4 MeV linear accelerator were applied with focal doses of 40 to 44 Gy. Contrast simulator radiographs were made in order to verify the position within the irradiation field of the organs from which biopsies were taken. In 0/10 patients examined before the irradiation, 0/5 patients examined less than 15 weeks after the irradiation, and 0/12 patients examined 15 weeks or later after the irradiation, histomorphologic investigation of the mucosa of the esophagus showed no pathologic findings. With the same intervals of examination related to irradiation, the gastric mucosa showed a pathologic histomorphology in 1/13, 7/9, and 5/9 patients, respectively, and the duodenal mucosa in 0/13, 5/9, and 2/9 patients, respectively. With the exception of one ulcer in the duodenal bulb the histopathologic findings as well as the macroscopic findings were neither significant nor characteristic, i.e. not radiospecific. Most of these findings were inflammatory alterations of the mucosa, erosions, and capillarectasies.

Adult↗
PubMed1984

[Alternative use of the simulator method and computer tomography in planning radiotherapy for non-metastasizing prostatic cancer].

Simulator method and computed tomography use different pictures for measurements of the tumor volume for therapy planning: X-ray pictures taken from two different directions can only show the indirect volume of the tumor, while CT pictures give information of the real size of the tumor. For estimation of the value of the two methods therapy planning was performed by the simulator method in 34 patients with carcinoma of the prostate (T1-T3) and the results were added to CT pictures. Comparison of the two methods resulted in equivalent consequences. Therefore economic aspects should be taken into account for selection of a special method of radiation therapy planning.

Humans↗
PubMed1982

Interstitial radiotherapy with 198Au seeds in the primary management of carcinoma of the oral tongue: results in Freiburg/Breisgau from January 1964 to July 1980.

Thirty-two patients with histologically proven carcinoma of the oral tongue, Stage T1-3, were analyzed retrospectively. They were treated from January 1964 through July 1980 in Freiburg by interstitial implantation with Au-198-seeds for the primary tumor management. Out of 25 patients with complete follow-up, one patient developed a local recurrence. In three patients, regional lymph node metastases occurred, once after prior adjuvant radiotherapy to the regional lymph nodes area, and in two patients after exclusive interstitial radiotherapy to the tumor of the tongue. The overall five-year survival rate was 52% for all stages (overall group), 75% for Stage T1 and 44% for Stages T2-3. The corrected five-year survival rate was 75% for all stages, 86% for Stage T1 and 71% for Stages T2-3. The method of 198Au-seed implantation as it is practiced in Freiburg is discussed, as well as the radiation exposure of the personnel.

Adult↗
PubMed1982

[Pulmonary radioreaction demonstrated by x-ray pictures (author's transl)].

X-ray radiographs of the thorax of 119 patients suffering from Morbus Hodgkin (period of therapy VI/1974-III/1979) which have been taken during radiotherapy and at routine follow up examinations have been analysed with regard to temporal progress and extent of the pulmonary radioreaction after standardised mantle-field irradiation with a 4-MeV linear accelerator, extended-field satellite technique and tumor doses of 40-46 Gy. After a characteristic latency period without radio-morphological reaction the patients on average showed 12 weeks after beginning of irradiation signs of a beginning pneumonitis (phase I), after 15 weeks a florid pneumonitis (phase IIa), and after 20 weeks a florid pneumonitis with beginning shrinkage (phase IIb). After 5-9 months (average level 34 weeks) the pulmonary radioreaction was complete after having reached a steady paramediastinal lung fibrosis (phase IV). Classifying the radioreaction into 3 degrees of gravity a light pneumonitis was found in 44%, a medium one in 29%, and a severe pneumonitis in 16% of the cases. For clinical use it is important to know that after beginning shrinkage new expansion of mediastinum and/or of peripheral parenchymal shadows cannot be radioreactions. Primarily these new changes have to be interpreted as recurrence.

Adolescent↗
PubMed1982

[Risk of infection by iatrogenic asplenia--a study about the indication of exploratory laparotomy with splenectomy (LS) in case of Hodgkin's disease].

A retrospective evaluation of the data of all patients with Hodgkin's disease (collective of Freiburg) treated between 1964 and 1977 was made in order to find out if there was an increased risk of infection after a diagnostic laparotomy with splenectomy (LS). Among a total number of 592 patients, 277 had been submitted to LS (since 1969). 185 patients had a total remission, 130 of them after primary LS, 34 after secondary LS, and 21 without any treatment of the spleen. An inquiry conducted by means of a questionnaire showed no differences between the compared groups as to the frequency of not septic infections such as pulmonary tuberculosis, angina tonsillaris, pyodermia, sinusitis, complications in wound healing, urinary tract infections, and infections of the intestine. However, there was a significant increase of unspecific pneumonias and herpes zoster manifestations after (long-term observation) secondary LS. There were no differences regarding the frequency of febrile and not febrile colds, but after LS, the colds had a longer and more severe course.--The analysis of the cause of death in the 277 patients who died showed a lethal septicaemia in seven cases. All these patients had been submitted to LS. In three of these patients, a recurrence was proved or could not be excluded, four presented as total remission with respect to Hodgkin's disease.--These results and the communications of literature permit to conclude that the iatrogenic asplenia represents an additional immunological risk. They suggest a further reduction of the indication for LS, the criteria of which are discussed.

Adolescent↗